IRIS
LAVECCHIA, ANTONIO
 Distribuzione geografica
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Continente #
NA - Nord America 3.411
EU - Europa 3.211
AS - Asia 866
AF - Africa 63
SA - Sud America 26
OC - Oceania 6
Continente sconosciuto - Info sul continente non disponibili 3
Totale 7.586
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Nazione #
US - Stati Uniti d'America 3.319
IT - Italia 1.662
CN - Cina 523
UA - Ucraina 322
NL - Olanda 302
IE - Irlanda 255
DE - Germania 192
FI - Finlandia 179
IN - India 93
GB - Regno Unito 89
CA - Canada 83
SE - Svezia 81
TR - Turchia 47
VN - Vietnam 47
CI - Costa d'Avorio 36
FR - Francia 24
ES - Italia 20
JP - Giappone 20
KR - Corea 19
TW - Taiwan 19
ID - Indonesia 14
IR - Iran 14
LU - Lussemburgo 14
RU - Federazione Russa 14
SG - Singapore 14
BR - Brasile 13
PK - Pakistan 12
CH - Svizzera 11
HK - Hong Kong 9
PH - Filippine 9
CZ - Repubblica Ceca 8
ZA - Sudafrica 8
MX - Messico 7
GR - Grecia 6
NG - Nigeria 6
PE - Perù 6
RO - Romania 5
TH - Thailandia 5
BE - Belgio 4
DK - Danimarca 4
DZ - Algeria 4
CO - Colombia 3
ET - Etiopia 3
EU - Europa 3
HU - Ungheria 3
IQ - Iraq 3
JO - Giordania 3
LK - Sri Lanka 3
PL - Polonia 3
RS - Serbia 3
AL - Albania 2
AU - Australia 2
AZ - Azerbaigian 2
CL - Cile 2
CU - Cuba 2
EC - Ecuador 2
EG - Egitto 2
FJ - Figi 2
IL - Israele 2
KE - Kenya 2
MA - Marocco 2
NP - Nepal 2
NZ - Nuova Zelanda 2
SA - Arabia Saudita 2
AT - Austria 1
BD - Bangladesh 1
BY - Bielorussia 1
HR - Croazia 1
KZ - Kazakistan 1
LV - Lettonia 1
MD - Moldavia 1
MO - Macao, regione amministrativa speciale della Cina 1
MT - Malta 1
NO - Norvegia 1
PS - Palestinian Territory 1
PT - Portogallo 1
Totale 7.586
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Città #
Chandler 617
Jacksonville 306
Amsterdam 296
Millbury 195
Princeton 183
Napoli 180
Naples 149
Nanjing 140
Boston 133
Ashburn 115
Ann Arbor 110
Wilmington 105
Beijing 98
Houston 83
Woodbridge 82
Rome 74
Redwood City 61
Des Moines 57
Ottawa 52
Milan 49
Boardman 40
Kronberg 38
Salerno 38
Nanchang 35
Shenyang 35
Hebei 28
Dong Ket 26
Falls Church 26
Lawrence 23
Changsha 21
Jiaxing 21
Norwalk 18
Dublin 17
Hanoi 17
Tianjin 17
Wuhan 16
Catania 15
Shanghai 15
Taipei 15
Toronto 14
Florence 12
London 12
Pune 12
Bari 11
Bologna 11
Indiana 11
Kunming 11
Orange 11
Cagliari 10
Genoa 10
Palermo 10
Siano 10
Washington 10
Delhi 9
Frankfurt am Main 9
Istanbul 9
Padova 9
Pisa 9
Dallas 8
Fairfield 8
Jakarta 8
Singapore 8
Caserta 7
Mountain View 7
Siena 7
Turin 7
Zhengzhou 7
Bergamo 6
Chennai 6
Chongqing 6
Hangzhou 6
Johannesburg 6
Pontedera 6
Tokyo 6
Çanakkale 6
Busto Arsizio 5
Camerino 5
Chengdu 5
Chicago 5
Compton 5
Guangzhou 5
Lima 5
Los Angeles 5
New York 5
Pistoia 5
Portici 5
Reggio Calabria 5
Rende 5
San Giovanni la Punta 5
Stockholm 5
Taranto 5
Torino 5
Ankara 4
Bogor 4
Buccino 4
Cambridge 4
Formia 4
Gavirate 4
Ibaraki 4
Indianapolis 4
Totale 3.978
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Nome #
Machine-learning approaches in drug discovery: methods and applications 717
Progettazione ed identificazione, mediante metodi computazionali integrati, di nuovi inibitori delle fosfatasi Cdc25 e della tubulina quali agenti anticancro 658
Inibitori di proteine di prenilazione come agenti antitumorali: processo di preparazione ed impieghi in campo medico. 252
Progettazione, Sintesi e Valutazione Biologica di Nuovi Ligandi del Recettore Nucleare PPAR gamma con Proprietà Antiproliferative e Pro-apoptotiche 167
Modello strutturale del dominio transmembrana del recettore oppioide kappa e relativi binding modes di ligandi benzomorfanici ed arilacetamidici kappa-selettivi 132
Discovery of new small molecules inhibiting 67 kDa laminin receptor interaction with laminin and cancer cell invasion 111
Urokinase-type plasminogen activator receptor (uPAR) expression enhances invasion and metastasis in RAS mutated tumors 84
5'-C-ethyl-tetrazolyl-N 6-substituted adenosine and 2-chloro-adenosine derivatives as highly potent dual acting A1 adenosine receptor agonists and A3 adenosine receptor antagonists 75
[1,2,4]Triazino[4,3-a]benzimidazole Acetic Acid Derivatives: a New Series of Selective Aldose Reductase Inhibitors 70
Antitumor agents. 5. synthesis, structure-activity relationships, and biological evaluation of dimethyl-5H-pyridophenoxazin-5-ones, tetrahydro-5h-benzopyridophenoxazin-5-ones, and 5h-benzopyridophenoxazin-5-ones with potent antiproliferative activity 68
Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide 68
The 37/67kDa laminin receptor (LR) inhibitor, NSC47924, affects 37/67kDa LR cell surface localization and interaction with the cellular prion protein 68
Progettazione e Sintesi di Nuovi Farmaci Antitumorali: Intercalanti del DNA ed Inibitori della Farnesiltransferasi 65
Synthesis, Biological Evaluation, and Molecular Modeling of Ribose-Modified Adenosine Analogues as Adenosine Receptor Agonists 60
Antagonizing S1P3 receptor with cell-penetrating pepducins in skeletal muscle fibrosis 60
" Molecular Modelingof the Urotensin-II receptor Complex" 58
Activation of Non-Canonical Autophagic Pathway through Inhibition of Non-Integrin Laminin Receptor in Neuronal Cells 58
Modeling of Cdc25B Dual Specifity Protein Phosphatase Inhibitors: Docking of Ligands and Enzymatic Inhibition Mechanism 57
Molecular Modeling of the Urotensin-UT Receptor Complex 57
43. Synthesis, Antiproliferative Activity, and Molecular Modelling of New DNA Intercalating Pyridophenoxazinone Carboxamides 56
ANTITUMOR AGENTS. 1. SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR MODELING OF 5H-PYRIDO[3,2-A]PHENOXAZIN-5-ONE, A NEW ACTYNOMICIN D ANALOG WITH POTENT ANTIPROLIFERATIVE ACTIVITY, 55
Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A1 adenosine receptor antagonists 55
2-(Benzimidazol-2-yl)quinoxalines: a Movel Class of Selective Antagonists at Human A(1) and A(3) Adenosine Receptors Designed by 3D Database Searching. 55
Novel, Highly Potent Aldose Reductase Inhibitors: Cyano-(2-oxo-2,3-dihydroindol-3-yl)-acetic Acid Derivatives 53
Insights into the Mechanism of Partial Agonism. Crystal Structures of the Peroxisome Proliferator-Activated Receptor Ligand-Binding Domain in the Complex with two Enantiomeric Ligands 52
67 kDa Laminin Receptor (67LR) Involvement in the Trafficking of Normal and Leukemic Hematopoietic Stem Cells; Computer-Aided Identification of a Small Inhibitory Molecule 52
Novel Non-Peptide Small Molecules Preventing IKKβ/NEMO Association Inhibit NF-κB Activation in LPS-Stimulated J774 Macrophages 52
Synthesis, Pharmacological Evaluation, and Molecular Modeling Studies of Novel Peptidic CAAX Analogues as Farnesyl-Protein-Transferase Inhibitors 51
Novel, Highly Potent Adenosine Deaminase Inhibitors Containing the Pyrazolo[3,4-d]pyrimidine Ring System. Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies 51
A compound-based proteomic approach discloses 15-ketoatractyligenin methyl ester as a new PPARγ partial agonist with anti-proliferative ability 50
On the Metabolically Active Form of Metaglidasen: Improved Synthesis and Investigation of Its Peculiar Activity on Peroxisome Proliferator-Activated Receptors and Skeletal Muscles 49
Antitumor Agents. 4. Characterization of Free Radicals Produced During Reduction of the Antitumor Drug 5H-Pyridophenoxazin-5-one (PPH). An EPR Study. 49
Antitumor agents 6. Synthesis, structure-activity relationships, and biological evaluation of spiro[imidazolidine-4,3'-thieno[2,3-g]quinoline]-tetraones and spiro[thieno[2,3-g]quinoline-3,5'-[1,2,4]triazinane]-tetraones with potent antiproliferative activity 49
Discovery of New Small Molecules Targeting the Vitronectin Binding Site of the Urokinase Receptor That Block Cancer Cell Invasion 49
Analoghi degli acidi clofibrici e loro uso come ligandi dei recettori nucleari peroxisome proliferator activated receptor (PPAR) alpha e gamma" 48
5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species 48
Ligand Binding Analysis for Human alfa 5 beta 1 Integrin: Strategies for Designing New alfa 5 beta 1 Integrin Antagonists 47
Cdc25 inhibitors in melanoma cells 47
3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: A New Class of Selective A1 Adenosine Receptor Antagonists. 46
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2-aryloxyalkanoic acids: A docking and molecular dynamics study 46
Regulation of trafficking and folding of cellular prion protein PrPC and its shadow Shadoo 46
App maturation and intracellular localization are controlled by a specific inhibitor of 37/67 kda laminin-1 receptor in neuronal cells 46
Antagonizing S1P3 receptor with Cell-Penetrating Pepducins in Skeletal Muscle Fibrosis 46
Antitumor Agents. 1. Synthesis, Biological Evaluation and Molecular Modeling of 5H-pyrido[3,2-a]phenoxazin-5-one, a Compound with Potent Antiproliferative Activity 45
Ligand-based chemoinformatic discovery of a novel small molecule inhibitor targeting CDC25 dual specificity phosphatases and displaying in vitro efficacy against melanoma cells 45
Arylthioindole Inhibitors of Tubulin Polymerization. 3. Biological Evaluation, Structure-Activity Relationships and Molecular Modeling Studies 44
Design, Synthesis, Biological Evaluation, and Molecular Modeling Studies of TIBO-Like Cyclic Sulfones as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors 44
Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines 44
A1 adenosine receptor antagonists, 3-aryl[1,2,4]triazino[4,3-a]benzimidazol-4-(10H)-ones (ATBIs) and N-alkyl and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs): Different recognition of bovine and human binding sites 43
Reaction between Quinone and Thiazolidine. A Study on the Formation Mechanism of New Antiproliferative Quinolindiones 43
Discovery of a Novel Small Molecule Inhibitor Targeting the Frataxin/Ubiquitin Interaction via Structure-Based Virtual Screening and Bioassays 43
Antitumor Agents. 2. Synthesis, Structure-Activity Relationships and Biological Evaluation of Novel 5H-pyridophenoxazin-5-ones with Potent Antiproliferative Activity 42
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of New Chiral Fibrates with PPARα and PPARγ Agonist Activity 42
Arylthiopyrrole (AThP) Derivatives as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors. Synthesis, Structure-Activity Relationships and Docking Studies. Part 2. 41
Novel Bifunctional Quinolonyl Diketo Acid Derivatives as HIV-1 Integrase Inhibitors: Design, Synthesis, Biological Activities, and Mechanism of Action 41
New Pyrrole Inhibitors of Monoamine Oxidase: Synthesis, Biological Evaluation and Structural Determinants of MAO-A and MAO-B Selectivity 41
Discovery of New Small Molecules Targeting the Vitronectin-Binding Site of the Urokinase Receptor That Block Cancer Cell Invasion 41
Amorfrutins are efficient modulators of peroxisome proliferator-activated receptor gamma (PPARγ) with potent antidiabetic and anticancer properties: A patent evaluation of WO2014177593 A1 41
N-formyl peptide receptors induce radical oxygen production in fibroblasts derived from systemic sclerosis by interacting with a cleaved form of urokinase receptor 41
Characterizing the 1,4-Dihydropyridines Binding Interactions in the L-Type Ca2+ Channel: Model Construction and Docking Calculations 40
Syntheses, Biological Evaluation and Molecular Modeling of 18F-labeled 4-Anilidopiperidines as μ-Opioid Receptor Imaging Agents 40
Synthesis, cannabinoid receptor affinity, and molecular modeling studies of substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides 40
Discovery of New Inhibitors of Cdc25B Dual Specificity Phosphatases by Structure-Based Virtual Screening 40
Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): a New Class of Agents endowed with High Apoptotic Activity in Chronic Myelogenous Leukemia K562 Cells and in Cells from Patients at Onset and Imatinib-Resistant. 39
Computer-Aided Engineering of GPCRs and Its Application to Drug Discovery 38
Docking Studies on Bifunctional Quinolinyl Diketo Acids as HIV-1 Integrase Inhibitors. 38
Synthesis and Structural Analysis of Cyclic Oligomers Consisting of Furanoid and Pyranoid epsilon-Sugar Amino Acids 38
Docking Studies on avb3 Integrin Ligands: Pharmacophore Refinement and Implications for Drug Design 38
Solution of a Potent Cyclic Analog of Tufsin: A Low Temperature NMR Study in a Cryoprotective Mixture 38
Design, Molecular Modeling, Synthesis, and Anti-HIV-1 Activity of New Indolyl Aryl Sulfones. Novel Derivatives of the Indole-2-carboxamide 38
Elucidation of the Enantioselective Recognition Mechanism of a Penicillin G Acylase-Based Chiral Stationary Phase Towards a Series of 2-Aryloxy-2-Aryl-Acetic Acids. 38
Naphtho[1,2-d]isothiazole Acetic Acid Derivatives as a Novel Class of Selective Aldose Reductase Inhibitors 38
Progettazione e sintesi di nuovi farmaci antitumorali: intercalanti del Dna e inibitori delle Farnesil Trasferasi 38
Novel Quinolinonyl Diketo Acid Derivatives as HIV-1 Integrase Inhibitors: Design, Synthesis, and Biological Activities 37
Virtual Screening Strategies in Drug Discovery: a Critical Review 37
Inhibition mechanism of naphthylphenylamine derivatives acting on the CDC25B dual phosphatase and analysis of the molecular processes involved in the high cytotoxicity exerted by one selected derivative in melanoma cells 37
In silico methods to address polypharmacology: Current status, applications and future perspectives 36
The antiproliferative and proapoptotic effects of cladosporols A and B are related to their different binding mode as PPARγ ligands 36
Novel Highly Potent Adenosine Deaminase Inhibitors Containing the Pyrazolo[3,4-d]pyrimidine Ring System. Synthesis, Structure-Activity Relationships and Molecular Modeling Studies. 35
Structure-Activity Studies of the Melanocortin Peptides: Discovery of Potent and Selective Antagonists at hMC3 and hMC4 Receptors 35
Synthesis, Molecular Modeling and mu-Opioid Receptor Affinity of 9,10-Diazatricyclo[4.2.1.12,5] decanes and 2,7-Diazatricyclo[4.4.0.03,8]decanes Structurally Related to 3,8-Diazabicyclo[3.2.1]octanes 35
Arylthiopyrrole (AThP) Derivatives as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors. Synthesis, Structure-Activity Relationships and Docking Studies. Part 1. 35
Architecture of the Human Urotensin II Receptor: Comparison of the Binding Domains of Peptide and Non-Peptide Urotensin II Agonists 35
Pharmacokinetic profile of atenolol aspirinate 35
Solution conformation of a potent cyclic analog of Tuftsin : low temperature nuclear magnetic resonance study in a cryoprotective mixture. 34
Conformational Analysis of Furanoid e-Sugar Amino Acid Containing Cyclic Peptides by NMR Spectroscopy, Molecular Dynamics Simulation, and X-ray Crystallography: Evidence for a Novel Turn Structure 33
Synthesis, Biological Evaluation and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalfa and PPARgamma Agonist Activity 33
Novel N-(Arylalkyl)indol-3-ylglyoxylyamides Targeted as Ligands of the Benzodiazepine Receptor: Synthesis, Biological Evaluation, and Molecular Modeling Analysis of the Structure-Activity Relationships 32
Design and Synthesis of 2-Heterocyclyl-3-arylthio-1H-indoles as Potent Tubulin Polymerization and Cell Growth Inhibitors with Improved Metabolic Stability 32
Antitumor agents. 3. Design, synthesis, and biological evaluation of new pyridoisoquinolindione and dihydrothienoquinolindione derivatives with potent cytotoxic activity 32
3D structure and biological activity of novel dual peroxisome proliferator-activated receptors alpha/gamma ligands 32
Discovery Of Novel Peroxisome Proliferator-Activated Receptor γ (PPARγ) Scaffolds With Partial Agonist Binding Properties By Integrated In Silico/In Vitro Work Flow 32
Small Molecule Drugs And Targeted Therapy For Melanoma: Current Strategies And Future Directions 32
Spirohydantoin Derivatives of Thiopyrano[2,3-b]pyridin-4(4H)-one as Potent In Vitro and In Vivo Aldose Reductase Inhibitors 31
Benzodiazepine Derivatives and Uses Thereof in Medical Field 31
Computer-Assisted Design, Synthesis and Biological Evaluation of Novel Pyrrolyl Heteroaryl Sulfones Targeted at HIV-1 Reverse Transcriptase as Non-Nucleoside Inhibitors. 31
Structure-based design, synthesis, and in vivo antinociceptive effects of selective A1 adenosine receptor agonists 31
Antitumor agents 7. Synthesis, antiproliferative activity and molecular modeling of new L-lysine-conjugated pyridophenoxazinones as potent DNA-binding ligands and topoisomerase IIα inhibitors 31
Modeling of k-Opioid Receptor/Agonists Interactions Using Pharmacophore-Based and Docking Simulations 30
Enantioselective Hydrolysis of Some 2-Aryloxyalkanoic Acid Methyl Esters and Isosteric Analogs Using a Penicillin G Acylase Based HPLC Monolithic Silica Column 30
Totale 6.205
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Categoria #
all - tutte 24.839
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 24.839
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/201919 0 0 0 0 0 0 0 0 0 0 6 13
2019/2020887 264 16 69 17 117 14 9 3 15 76 148 139
2020/20211.099 36 91 84 107 162 143 99 45 122 39 90 81
2021/20221.389 42 21 45 34 28 57 31 66 275 55 180 555
2022/20231.977 271 147 61 202 153 168 105 157 248 296 101 68
2023/20241.129 80 167 178 87 72 106 115 213 44 56 11 0
Totale 7.988