CINECA IRIS Institutional Research Information System

IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.

Prodotti recenti

Protein-metallodrugs interactions: Effects on the overall protein structure and characterization of Au, Ru and Pt binding sites

The effects of metalation process by inorganic compounds containing Au, Pt and Ru on protein structure and on conformation and flexibility of the residues involved in the metal compound binding have been here investigated by analysing 204 structures of protein/metallodrug adducts and&#x...

The first step of arsenoplatin-1 aggregation in solution unveiled by solving the crystal structure of its protein adduct

Arsenoplatin-1 (AP-1) is an innovative dual-action anticancer agent that contains a platinum(ii) center coordinated to an arsenous acid moiety. We found that AP-1 spontaneously aggregates in aqueous solutions generating oligomeric species of increasing length. Afterward, we succeeded in solving the&#x...

Recent advances in protein metalation: structural studies

Protein metalation is a process that determines the formation of adducts upon reaction of metal compounds with proteins. Protein metalation plays a crucial role in different fields, determining the mechanism of action and toxicity of metal-based drugs and the basis for the rational ...

Interaction of Platinum-based Drugs with Proteins: An Overview of Representative Crystallographic Studies

Pt-based drugs are widely used in clinics for the treatment of cancer. The mechanism of action of these molecules relies on their interaction with DNA. However, the recognition of these metal compounds by proteins plays an important role in defining pharmacokinetics, side effects a...

Unusual structural features in the adduct of dirhodium tetraacetate with lysozyme

The structures of the adducts formed upon reaction of the cytotoxic paddlewheel dirhodium complex [Rh2(μ-O2CCH3)4] with the model protein hen egg white lysozyme (HEWL) under different experimental conditions are reported. Results indicate that [Rh2(μ-O2CCH3)4] extensively reacts with HEWL:it in part&#...

CINECA IRIS Institutional Research Information System

Prodotti recenti

Protein-metallodrugs interactions: Effects on the overall protein structure and characterization of Au, Ru and Pt binding sites

The first step of arsenoplatin-1 aggregation in solution unveiled by solving the crystal structure of its protein adduct

Recent advances in protein metalation: structural studies

Interaction of Platinum-based Drugs with Proteins: An Overview of Representative Crystallographic Studies

Unusual structural features in the adduct of dirhodium tetraacetate with lysozyme

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