LAVECCHIA, ANTONIO
LAVECCHIA, ANTONIO
Dipartimento di Farmacia
Regulation of trafficking and folding of cellular prion protein PrPC and its shadow Shadoo
2018 Pepe, Anna; Avolio, Rosario; Matassa, DANILO SWANN; Esposito, Franca; Nitsch, Lucio; Zurzolo, Chiara; Pesapane, Ada; Montuori, Nunzia; Lavecchia, Antonio; Paladino, Simona; Sarnataro, Daniela
In Silico Identification of Novel Inhibitors Targeting the Homodimeric Interface of Superoxide Dismutase from the Dental Pathogen Streptococcus mutans
2022 Cerchia, Carmen; Roscetto, Emanuela; Nasso, Rosarita; Catania, Maria Rosaria; De Vendittis, Emmanuele; Lavecchia, Antonio; Masullo, Mariorosario; Rullo, Rosario
Antagonizing S1P3 receptor with Cell-Penetrating Pepducins in Skeletal Muscle Fibrosis
2021 Scognamiglio, Antonia; Corvino, Angela; Esposito, Gianluca; Esposito, Giovanna; Santagada, Vincenzo; Lavecchia, Antonio; LO BIANCO, Alessandra; Roviezzo, Fiorentina; Donati, Chiara; Severino, Beatrice
A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity
2022 Sblano, Sabina; Cerchia, Carmen; Laghezza, Antonio; Piemontese, Luca; Brunetti, Leonardo; Leuci, Rosalba; Gilardi, Federica; Thomas, Aurelien; Genovese, Massimo; Santi, Alice; Tortorella, Paolo; Paoli, Paolo; Lavecchia, Antonio; Loiodice, Fulvio
A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects
2021 Yasmin, S.; Cerchia, C.; Badavath, V. N.; Laghezza, A.; Dal Piaz, F.; Mondal, S. K.; Atli, O.; Baysal, M.; Vadivelan, S.; Shankar, S.; Siddique, M. U. M.; Pattnaik, A. K.; Singh, R. P.; Loiodice, F.; Jayaprakash, V.; Lavecchia, A.
Discovery of a Novel Inhibitor of Human Purine Nucleoside Phosphorylase by a Simple Hydrophilic Interaction Liquid Chromatography Enzymatic Assay
2021 Rabuffetti, M.; Rinaldi, F.; Lo Bianco, A.; Speranza, G.; Ubiali, D.; de Moraes, M. C.; Rodrigues Pereira da Silva, L. C.; Massolini, G.; Calleri, E.; Lavecchia, A.
Thiazolidinedione "magic Bullets" Simultaneously Targeting PPARγand HDACs: Design, Synthesis, and Investigations of their in Vitro and in Vivo Antitumor Effects
2021 Tilekar, K.; Hess, J. D.; Upadhyay, N.; Bianco, A. L.; Schweipert, M.; Laghezza, A.; Loiodice, F.; Meyer-Almes, F. -J.; Aguilera, R. J.; Lavecchia, A.; Ramaa, C. S.
HDAC4 Inhibitors with Cyclic Linker and Non-hydroxamate Zinc Binding Group: Design, Synthesis, HDAC Screening and in vitro Cytotoxicity evaluation
2021 Tilekar, K.; Hess, J. D.; Upadhyay, N.; Schweipert, M.; Flath, F.; Gutierrez, D. A.; Loiodice, F.; Lavecchia, A.; Meyer-Almes, F. -J.; Aguilera, R. J.; Ramaa, C. S.
Current status and future prospects of molecular hybrids with thiazolidinedione (TZD) scaffold in anticancer drug discovery
2022 Tilekar, K.; Shelke, O.; Upadhyay, N.; Lavecchia, A.; Ramaa, C. S.
Activation of Non-Canonical Autophagic Pathway through Inhibition of Non-Integrin Laminin Receptor in Neuronal Cells
2022 Limone, Adriana; Veneruso, Iolanda; Izzo, Antonella; Renna, Maurizio; Bonavita, Raffaella; Piscitelli, Silvia; Calì, Gaetano; De Nicola, Sergio; Riccio, Patrizia; D’Argenio, Valeria; Lavecchia, Antonio; Sarnataro, Daniela
Inhibition mechanism of naphthylphenylamine derivatives acting on the CDC25B dual phosphatase and analysis of the molecular processes involved in the high cytotoxicity exerted by one selected derivative in melanoma cells
2020 Aliotta, F.; Nasso, R.; Rullo, R.; Arcucci, A.; Avagliano, A.; Simonetti, M.; Sanita, G.; Masullo, M.; Lavecchia, A.; Ruocco, M. R.; De Vendittis, E.
Antagonizing S1P3 receptor with cell-penetrating pepducins in skeletal muscle fibrosis
2021 Corvino, A.; Cerqua, I.; Lo Bianco, A.; Caliendo, G.; Fiorino, F.; Frecentese, F.; Magli, E.; Morelli, E.; Perissutti, E.; Santagada, V.; Cirino, G.; Granato, E.; Roviezzo, F.; Puliti, E.; Bernacchioni, C.; Lavecchia, A.; Donati, C.; Severino, B.
Pharmacophore hybridization approach to discover novel pyrazoline-based hydantoin analogs with anti-tumor efficacy
2021 Upadhyay, N.; Tilekar, K.; Loiodice, F.; Anisimova, N. Y.; Spirina, T. S.; Sokolova, D. V.; Smirnova, G. B.; Choe, J. -Y.; Meyer-Almes, F. -J.; Pokrovsky, V. S.; Lavecchia, A.; Ramaa, C. S.
5'-C-ethyl-tetrazolyl-N 6-substituted adenosine and 2-chloro-adenosine derivatives as highly potent dual acting A1 adenosine receptor agonists and A3 adenosine receptor antagonists
2015 Petrelli, Riccardo; Torquati, Ilaria; Kachler, Sonja; Luongo, Livio; Maione, Sabatino; Franchetti, Palmarisa; Grifantini, Mario; Novellino, Ettore; Lavecchia, Antonio; Klotz, Karl-Norbert; Cappellacci, Loredana
Identification of the First PPARα/γ Dual Agonist Able to Bind to Canonical and Alternate Sites of PPARγ and to Inhibit its Cdk5-Mediated Phosphorylation
2018 Laghezza, Antonio; Piemontese, Luca; Cerchia, Carmen; Montanari, Roberta; Capelli, Davide; Giudici, Marco; Crestani, Maurizio; Tortorella, Paolo; Peiretti, Franck; Pochetti, Giorgio; Lavecchia, Antonio; Loiodice, Fulvio
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode
2016 Capelli, Davide; Cerchia, Carmen; Montanari, Roberta; Loiodice, Fulvio; Tortorella, Paolo; Laghezza, Antonio; Cervoni, Laura; Pochetti, Giorgio; Lavecchia, Antonio
In silico methods to address polypharmacology: Current status, applications and future perspectives
2016 Lavecchia, Antonio; Cerchia, Carmen
Machine-learning approaches in drug discovery: methods and applications
2015 Lavecchia, A
Novel Non-Peptide Small Molecules Preventing IKKβ/NEMO Association Inhibit NF-κB Activation in LPS-Stimulated J774 Macrophages
2016 DE FALCO, Francesca; DI GIOVANNI, Carmen; Cerchia, Carmen; DE STEFANO, Daniela; Capuozzo, Antonella; Irace, Carlo; Iuvone, Teresa; Santamaria, Rita; Carnuccio, Rosa; Lavecchia, Antonio
Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide
2016 Caiazzo, Elisabetta; Maione, Francesco; Morello, Silvana; Lapucci, Andrea; Paccosi, Sara; Steckel, Bodo; Lavecchia, Antonio; Parenti, Astrid; Iuvone, Teresa; Schrader, Jürgen; Ialenti, Armando; Cicala, Carla
| Titolo | Tipologia | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|---|
| Regulation of trafficking and folding of cellular prion protein PrPC and its shadow Shadoo | 1.5 Abstract in rivista | 2018 | Pepe, Anna; Avolio, Rosario; Matassa, DANILO SWANN; Esposito, Franca; Nitsch, Lucio; Zurzolo, Chiara; Pesapane, Ada; Montuori, Nunzia; Lavecchia, Antonio; Paladino, Simona; Sarnataro, Daniela | |
| In Silico Identification of Novel Inhibitors Targeting the Homodimeric Interface of Superoxide Dismutase from the Dental Pathogen Streptococcus mutans | 1.1 Articolo in rivista | 2022 | Cerchia, Carmen; Roscetto, Emanuela; Nasso, Rosarita; Catania, Maria Rosaria; De Vendittis, Emmanuele; Lavecchia, Antonio; Masullo, Mariorosario; Rullo, Rosario | |
| Antagonizing S1P3 receptor with Cell-Penetrating Pepducins in Skeletal Muscle Fibrosis | 4.3 Poster | 2021 | Scognamiglio, Antonia; Corvino, Angela; Esposito, Gianluca; Esposito, Giovanna; Santagada, Vincenzo; Lavecchia, Antonio; LO BIANCO, Alessandra; Roviezzo, Fiorentina; Donati, Chiara; Severino, Beatrice | |
| A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity | 1.1 Articolo in rivista | 2022 | Sblano, Sabina; Cerchia, Carmen; Laghezza, Antonio; Piemontese, Luca; Brunetti, Leonardo; Leuci, Rosalba; Gilardi, Federica; Thomas, Aurelien; Genovese, Massimo; Santi, Alice; Tortorella, Paolo; Paoli, Paolo; Lavecchia, Antonio; Loiodice, Fulvio | |
| A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects | 1.1 Articolo in rivista | 2021 | Yasmin, S.; Cerchia, C.; Badavath, V. N.; Laghezza, A.; Dal Piaz, F.; Mondal, S. K.; Atli, O.; Baysal, M.; Vadivelan, S.; Shankar, S.; Siddique, M. U. M.; Pattnaik, A. K.; Singh, R. P.; Loiodice, F.; Jayaprakash, V.; Lavecchia, A. | |
| Discovery of a Novel Inhibitor of Human Purine Nucleoside Phosphorylase by a Simple Hydrophilic Interaction Liquid Chromatography Enzymatic Assay | 1.1 Articolo in rivista | 2021 | Rabuffetti, M.; Rinaldi, F.; Lo Bianco, A.; Speranza, G.; Ubiali, D.; de Moraes, M. C.; Rodrigues Pereira da Silva, L. C.; Massolini, G.; Calleri, E.; Lavecchia, A. | |
| Thiazolidinedione "magic Bullets" Simultaneously Targeting PPARγand HDACs: Design, Synthesis, and Investigations of their in Vitro and in Vivo Antitumor Effects | 1.1 Articolo in rivista | 2021 | Tilekar, K.; Hess, J. D.; Upadhyay, N.; Bianco, A. L.; Schweipert, M.; Laghezza, A.; Loiodice, F.; Meyer-Almes, F. -J.; Aguilera, R. J.; Lavecchia, A.; Ramaa, C. S. | |
| HDAC4 Inhibitors with Cyclic Linker and Non-hydroxamate Zinc Binding Group: Design, Synthesis, HDAC Screening and in vitro Cytotoxicity evaluation | 1.1 Articolo in rivista | 2021 | Tilekar, K.; Hess, J. D.; Upadhyay, N.; Schweipert, M.; Flath, F.; Gutierrez, D. A.; Loiodice, F.; Lavecchia, A.; Meyer-Almes, F. -J.; Aguilera, R. J.; Ramaa, C. S. | |
| Current status and future prospects of molecular hybrids with thiazolidinedione (TZD) scaffold in anticancer drug discovery | 1.1 Articolo in rivista | 2022 | Tilekar, K.; Shelke, O.; Upadhyay, N.; Lavecchia, A.; Ramaa, C. S. | |
| Activation of Non-Canonical Autophagic Pathway through Inhibition of Non-Integrin Laminin Receptor in Neuronal Cells | 1.1 Articolo in rivista | 2022 | Limone, Adriana; Veneruso, Iolanda; Izzo, Antonella; Renna, Maurizio; Bonavita, Raffaella; Piscitelli, Silvia; Calì, Gaetano; De Nicola, Sergio; Riccio, Patrizia; D’Argenio, Valeria; Lavecchia, Antonio; Sarnataro, Daniela | |
| Inhibition mechanism of naphthylphenylamine derivatives acting on the CDC25B dual phosphatase and analysis of the molecular processes involved in the high cytotoxicity exerted by one selected derivative in melanoma cells | 1.1 Articolo in rivista | 2020 | Aliotta, F.; Nasso, R.; Rullo, R.; Arcucci, A.; Avagliano, A.; Simonetti, M.; Sanita, G.; Masullo, M.; Lavecchia, A.; Ruocco, M. R.; De Vendittis, E. | |
| Antagonizing S1P3 receptor with cell-penetrating pepducins in skeletal muscle fibrosis | 1.1 Articolo in rivista | 2021 | Corvino, A.; Cerqua, I.; Lo Bianco, A.; Caliendo, G.; Fiorino, F.; Frecentese, F.; Magli, E.; Morelli, E.; Perissutti, E.; Santagada, V.; Cirino, G.; Granato, E.; Roviezzo, F.; Puliti, E.; Bernacchioni, C.; Lavecchia, A.; Donati, C.; Severino, B. | |
| Pharmacophore hybridization approach to discover novel pyrazoline-based hydantoin analogs with anti-tumor efficacy | 1.1 Articolo in rivista | 2021 | Upadhyay, N.; Tilekar, K.; Loiodice, F.; Anisimova, N. Y.; Spirina, T. S.; Sokolova, D. V.; Smirnova, G. B.; Choe, J. -Y.; Meyer-Almes, F. -J.; Pokrovsky, V. S.; Lavecchia, A.; Ramaa, C. S. | |
| 5'-C-ethyl-tetrazolyl-N 6-substituted adenosine and 2-chloro-adenosine derivatives as highly potent dual acting A1 adenosine receptor agonists and A3 adenosine receptor antagonists | 1.1 Articolo in rivista | 2015 | Petrelli, Riccardo; Torquati, Ilaria; Kachler, Sonja; Luongo, Livio; Maione, Sabatino; Franchetti, Palmarisa; Grifantini, Mario; Novellino, Ettore; Lavecchia, Antonio; Klotz, Karl-Norbert; Cappellacci, Loredana | |
| Identification of the First PPARα/γ Dual Agonist Able to Bind to Canonical and Alternate Sites of PPARγ and to Inhibit its Cdk5-Mediated Phosphorylation | 1.1 Articolo in rivista | 2018 | Laghezza, Antonio; Piemontese, Luca; Cerchia, Carmen; Montanari, Roberta; Capelli, Davide; Giudici, Marco; Crestani, Maurizio; Tortorella, Paolo; Peiretti, Franck; Pochetti, Giorgio; Lavecchia, Antonio; Loiodice, Fulvio | |
| Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode | 1.1 Articolo in rivista | 2016 | Capelli, Davide; Cerchia, Carmen; Montanari, Roberta; Loiodice, Fulvio; Tortorella, Paolo; Laghezza, Antonio; Cervoni, Laura; Pochetti, Giorgio; Lavecchia, Antonio | |
| In silico methods to address polypharmacology: Current status, applications and future perspectives | 1.1 Articolo in rivista | 2016 | Lavecchia, Antonio; Cerchia, Carmen | |
| Machine-learning approaches in drug discovery: methods and applications | 1.1 Articolo in rivista | 2015 | Lavecchia, A | |
| Novel Non-Peptide Small Molecules Preventing IKKβ/NEMO Association Inhibit NF-κB Activation in LPS-Stimulated J774 Macrophages | 1.1 Articolo in rivista | 2016 | DE FALCO, Francesca; DI GIOVANNI, Carmen; Cerchia, Carmen; DE STEFANO, Daniela; Capuozzo, Antonella; Irace, Carlo; Iuvone, Teresa; Santamaria, Rita; Carnuccio, Rosa; Lavecchia, Antonio | |
| Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide | 1.1 Articolo in rivista | 2016 | Caiazzo, Elisabetta; Maione, Francesco; Morello, Silvana; Lapucci, Andrea; Paccosi, Sara; Steckel, Bodo; Lavecchia, Antonio; Parenti, Astrid; Iuvone, Teresa; Schrader, Jürgen; Ialenti, Armando; Cicala, Carla |