IRIS
ZAMPELLA, ANGELA
 Distribuzione geografica
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Continente #
NA - Nord America 3.577
EU - Europa 2.192
AS - Asia 1.505
AF - Africa 57
SA - Sud America 10
Continente sconosciuto - Info sul continente non disponibili 3
OC - Oceania 2
Totale 7.346
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Nazione #
US - Stati Uniti d'America 3.492
IT - Italia 1.220
SG - Singapore 764
CN - Cina 582
IE - Irlanda 279
FI - Finlandia 237
UA - Ucraina 103
NL - Olanda 100
CA - Canada 81
DE - Germania 78
GB - Regno Unito 56
IN - India 50
CI - Costa d'Avorio 49
SE - Svezia 46
VN - Vietnam 44
ID - Indonesia 17
FR - Francia 15
JP - Giappone 11
HK - Hong Kong 10
KR - Corea 9
ES - Italia 8
CH - Svizzera 7
BE - Belgio 6
AT - Austria 5
CL - Cile 5
TR - Turchia 5
IR - Iran 4
RU - Federazione Russa 4
BG - Bulgaria 3
EG - Egitto 3
MX - Messico 3
PK - Pakistan 3
PT - Portogallo 3
RO - Romania 3
ZA - Sudafrica 3
AL - Albania 2
AR - Argentina 2
CZ - Repubblica Ceca 2
DK - Danimarca 2
EU - Europa 2
JE - Jersey 2
KE - Kenya 2
MT - Malta 2
NZ - Nuova Zelanda 2
PL - Polonia 2
A1 - Anonimo 1
AE - Emirati Arabi Uniti 1
BR - Brasile 1
BY - Bielorussia 1
CO - Colombia 1
EE - Estonia 1
GR - Grecia 1
IM - Isola di Man 1
KZ - Kazakistan 1
LI - Liechtenstein 1
MY - Malesia 1
OM - Oman 1
PA - Panama 1
PE - Perù 1
PH - Filippine 1
RS - Serbia 1
SK - Slovacchia (Repubblica Slovacca) 1
TW - Taiwan 1
Totale 7.346
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Città #
Chandler 647
Singapore 616
Millbury 268
Naples 248
Princeton 224
Napoli 196
Nanjing 166
Boston 154
Ashburn 136
Santa Clara 133
Jacksonville 124
Beijing 115
Amsterdam 83
Des Moines 81
Wilmington 80
Ottawa 73
Nanchang 59
Shenyang 45
Dong Ket 44
Hebei 43
Lawrence 37
Woodbridge 37
Salerno 33
Pune 31
Jiaxing 30
Rome 30
Tianjin 27
Angri 26
Norwalk 26
Falls Church 24
Houston 24
Ann Arbor 23
Formia 23
Changsha 21
Boardman 18
Milan 17
Seattle 17
Shanghai 17
Kronberg 14
Redwood City 14
Perugia 12
Jakarta 11
Kunming 10
Bologna 9
Dublin 9
Frattamaggiore 8
Lappeenranta 8
Lund 8
Oulu 8
Piemonte 8
Rende 8
Sesto Fiorentino 8
Torre Annunziata 8
Washington 8
Cagliari 7
Los Angeles 7
Mountain View 7
Fairfield 6
Lanzhou 6
Orange 6
Redmond 6
Shenzhen 6
Brea 5
Indiana 5
Monza 5
Palermo 5
Turin 5
Bari 4
Binzhou 4
Caserta 4
Castellammare Di Stabia 4
Chennai 4
Helsinki 4
Hong Kong 4
Ikari 4
Langhirano 4
Ludhiana 4
Regensburg 4
San Francisco 4
San Leucio 4
South Tangerang 4
Vico Equense 4
Yellow Springs 4
Ancona 3
Bacoli 3
Boulder 3
Brescia 3
Brussels 3
Changchun 3
Chions 3
Cosenza 3
Dallas 3
Gaeta 3
Hangzhou 3
Leawood 3
Prineville 3
Queenstown Estate 3
Rho 3
San Cesareo 3
San Giorgio A Cremano 3
Totale 4.338
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Nome #
Characterisation of the dynamic interactions between complex N-glycans and human CD22 94
Guida Ragionata allo Svolgimento di Esercizi di Chimica Organica 87
Design, synthesis and pharmacological characterization of novel potent nonsteroidal agonists of the farnesoid X receptor 66
Hyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists 64
Traduzione-CHIMICA ORGANICA Settima Edizione J. McMURRY 61
Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury 60
Identification of cysteinyl-leukotriene-receptor 1 antagonists as ligands for the bile acid receptor GPBAR1 60
Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists 59
Targeting bile acid receptors: discovery of a potent and selective Farnesoid X receptor agonist as a new lead in the pharmacological approach to liver diseases 58
Harnessing interrupted Fischer in continuous flow: sustainable synthesis of (spiro)indolenine and (spiro)indoline privileged scaffolds 57
Bile acid modulators for the treatment of nonalcoholic steatohepatitis (NASH) 57
Hijacking SARS-CoV-2/ACE2 Receptor Interaction by Natural and Semi-synthetic Steroidal Agents Acting on Functional Pockets on the Receptor Binding Domain 57
Discovery of a Potent and Orally Active Dual GPBAR1/CysLT1R Modulator for the Treatment of Metabolic Fatty Liver Disease 57
Identification of new GPBAR1 selective agonists containing an epoxide group on cholane side chains 53
Synthesis, Pharmacological Evaluation, and Molecular Modeling Studies of Novel Peptidic CAAX Analogues as Farnesyl-Protein-Transferase Inhibitors 52
Discovery of UDCA derivatives as new modulators of bile acid receptors 52
Quantum mechanical calculation of coupling constants in the configurational analysis of flexible systems: determination of the configuration of Callipeltin A 51
Theonella swinhoei as a source of anti-inflammatory cyclopeptides 51
Synthesis of new isoxazole derivatives as fxr agonists with improved pharmacokinetic properties 51
Cystathionine γ-lyase, a H2S-generating enzyme, is a GPBAR1-regulated gene and contributes to vasodilation caused by secondary bile acids 50
Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists 50
Bile acids derivatives in the selective modulation of FXR and GP-BAR1 50
Discovering New G-Quadruplex DNA Catalysts in Enantioselective Sulfoxidation Reaction 50
Concise synthesis of AHMHA unit in perthamide C. Structural and stereochemical revision of perthamide C 49
Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors 49
Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1 49
Modification on Ursodeoxycholic Acid (UDCA) Scaffold. Discovery of Bile Acid Derivatives As Selective Agonists of Cell-Surface G-Protein Coupled Bile Acid Receptor 1 (GP-BAR1) 48
Callipeltins F-I: new antifungal peptides from the marine sponge Latrunculia sp. 48
Inspection on bile acid scaffold in the discovery of the first example of LXRa/GPBAR1 dual agonists 48
Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties 47
Marine and semi-sinthetic hydroxystroids as new scaffolds for pregnane X receptor modulation 46
Molecular decodification of gymnemic acids from Gymnema sylvestre. Discovery of a new class of liver X receptor antagonists 46
Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling 46
Farnesoid X receptor modulators 2014-present: a patent review 45
Design and synthesis of hyodeoxycholic acid derivatives as GPBAR1 receptor modulators useful in the treatment of colon inflammation 45
Theonellasterols and Conicasterols from Theonella swinhoei. Novel marine natural ligands for human nuclear receptors 44
Chimica Organica 44
Plakilactones: a new class of marine agonists of the peroxisome proliferator-activated receptor ??? from Plakinastrella mamillaris 44
GPBAR1 activation by C6-substituted hyodeoxycholane analogues protect against colitis 44
Sphinxolides E-G and Redispongiolide C: Four New Cytotoxic Macrolides from the New Caledonian Lithistida Sponges Neosiphonia superstes and Redispongia coerulea 43
Bioactive cembrane derivatives from the Indian Ocean Soft Coral, Sinularia kavarattiensis 43
BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis 43
Synthesis of a new class of isoxazole derivatives with a dual FXR agonistic and COX-2 inhibitory activity. 43
BAR 501, a Novel GPBAR1 Ligand, Reverses Intestinal and Liver Inflammatory Models Demonstrating That GPBAR1 Is an Essential Modulator of Innate Immunity in Entero-Hepatic Tissues 42
Exploitation of Cholane Scaffold for the Discovery of Potent and Selective Farnesoid X Receptor (FXR) and G-Protein Coupled Bile Acid Receptor 1 (GP-BAR1) Ligands 41
The first total synthesis of solomonsterol B, a marine pregnane X receptor agonist 41
Solomonamides A and B: two unprecedented cyclic peptides from the marine sponge Theonella swinhoei 41
New jaspamide derivatives with antimicrofilament activity from the sponge Jaspis splendans 40
Conicasterol E, a small heterodimer partner sparing farnesoid-X-receptor modulator endowed with a pregnane-X-receptor agonistic activity, from the marine sponge Theonella swinhoei 40
Decoding the vasoregulatory activities of bile acid-activated receptors in systemic and portal circulation: Role of gaseous mediators 40
Critical surveys covering the year 2005: total synthesis of natural products 39
Isolation of Plakinamine I: a new steroidal alkaloid from the marine sponge Corticium sp. and synthesis of an analogue model compound 39
An advanced cellular assay for replicon-based antiviral screening of marine natural products 39
Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism 39
Investigation on bile acid receptor regulators. Discovery of cholanoic acid derivatives with dual G-protein coupled bile acid receptor 1 (GPBAR1) antagonistic and farnesoid X receptor (FXR) modulatory activity 39
Rational Drug Design of New Selective Modulators of GPBAR1 39
Bile acids derivatives in the selective modulation of FXR and GPBAR1 39
Computer-Aided Drug Design Unveils the Structural Requisites for Bile Acid Receptors Modulation 39
Discovery of Bile Acid Derivatives as Potent ACE2 Activators by Virtual Screening and Essential Dynamics 39
Structures of microfilament destabilizing toxins bound to actin provide insight into toxin design and activity 38
Discovery of Sulfated Sterols from Marine Invertebrates as a New Class of Marine Natural Antagonists of Farnesoid-X-Receptor 38
4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity 38
Anti-inflammatory cyclopeptides from the marine sponge Theonella swinhoei 38
Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands 38
Navigation in bile acid chemical space: discovery of novel FXR and GPBAR1 ligands 38
Absolute stereochemistry of marine macrolides Reidispongiolide A and Sphinxolide B 37
Discovery of a Novel Class of Dual GPBAR1 Agonists-RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders 36
Synthetic studies on callipeltin A: stereoselective synthesis of (2R,3R,4S)-3-hydroxy-2,4,6- trimethylheptanoic acid 36
Amphiasterins: a new family of cytotoxic metabolites from the marine sponge Plakortis quasiamphiaster 36
Bengamides and related new amino acid derivatives from the New Caledonian marine sponge Jaspis carteri 36
The First Total Synthesis of Solomonsterol B, a Marine Pregnane X Receptor Agonist 36
Perthamide C Inhibits eNOS and iNOS Expression and Has Immunomodulating Activity In Vivo 36
Antiviral and cytotoxic compounds from marine sponges of South Pacific 35
Synthesis of new bile acids derivatives as selective FXR/GPBAR1 ligands 35
Stereochemical determination of highly flexible systems by quantitative NMR-derived interproton distances combined with quantum mechanical calculations of 13C chemical shifts 35
Discovery of a new class of GPBAR1 modulators 35
Immunomodulatory functions of FXR 34
Farnesoid X receptor modulators (2011 - 2014): a patent review 34
Isolation of callipeltins A-C and of two new open-chain derivatives of callipeltin A from the marine sponge Latrunculia sp. A revision of the stereostructure of callipeltins. 34
Stereochemical assignment of the C23-C35 portion of sphinxolode/reidispongiolide class of natural products by asymmetric synthesis 34
Coscinolactams A and B: new nitrogen-containing sesterterpenoids from the marine sponge Coscinoderma mathewsi exerting anti-inflammatory properties 34
Cytotoxic and antiviral macrolides and cyclopeptides from New Caledonian Lithistida sponges 34
Discovery of cholanoic acid derivatives as new modulators of bile acid receptors 34
Epoxide functionalization on cholane side chains in the identification of G-protein coupled bile acid receptor (GPBAR1) selective agonists 34
Synthesis of a new class of isoxazole derivatives with a dual FXR agonistic and COX-2 inhibitory activity 34
Isolation and structural elucidation of callipeltins J-M: antifungal peptides from the marine sponge Latrunculia sp 33
Stereoselective synthesis of (2R,3R,4R)-3-hydroxy-2,4,6-trimethylheptanoic acid and determination of the absolute stereochemistry of the natural product from Callipeltin A 33
Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei 33
Inspection on bile acid scaffold in the discovery of the first example of LXR/GPBAR1 dual agonists 33
Bile acids activated receptors regulate innate immunity 33
Stereochemistry of Sphinxolides and Reidispongiolides. Asymmetric Synthesis of C17-C22 fragment of reidispongiolide A 32
Conicasterol E, a Small Heterodimer Partner Sparing Farnesoid X Receptor Modulator Endowed with a Pregnane X Receptor Agonistic Activity, from the Marine Sponge Theonella swinhoei 32
Bioactive metabolites from echinoderms and porifera 32
Towards FXR selectivity: manipulation of 6-ethylcholane scaffold 32
Decoding the role of the nuclear receptor SHP in regulating hepatic stellate cells and liver fibrogenesis 32
The bile acid receptor GPBAR1 (TGR5) is expressed in human gastric cancers and promotes epithelial-mesenchymal transition in gastric cancer cell lines 32
Disruption of TFGβ-SMAD3 pathway by the nuclear receptor SHP mediates the antifibrotic activities of BAR704, a novel highly selective FXR ligand 32
The bile acid activated receptors GPBAR1 and FXR exert antagonistic effects on autophagy 32
Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1 32
Chemical Proteomics, a Powerful Tool in the Analysis of Perthamide C Cellular Effects 31
Totale 4.308
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Categoria #
all - tutte 34.426
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 34.426
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020379 0 0 0 15 37 13 32 37 7 63 107 68
2020/2021651 23 45 58 36 79 117 62 37 74 23 33 64
2021/20221.345 30 11 16 7 16 45 30 64 290 41 163 632
2022/20231.553 278 123 31 148 187 172 21 157 250 88 68 30
2023/20241.225 65 174 143 49 44 109 47 110 46 50 272 116
2024/20251.039 405 551 71 12 0 0 0 0 0 0 0 0
Totale 7.772