As a part of our systematic study on secondary metabolites from marine organisms collected at Solomon Islands, we found a single specimen of the sponge Theonella swinhoei as an extraordinary source of anti-inflammatory cyclic cyclopeptides, such as perthamides C-K and solomonamides. Perthamides C-K are endowed of promising anti-inflammatory activity. The isolation of this small library of peptides allowed us to delineate a structure-activity relationship.
Theonella swinhoei as a source of anti-inflammatory cyclopeptides / Festa, C., DE MARINO, S., D'Auria, M.V., Monti, M.C., Bucci, M., Vellecco, V., Debitus, C., Zampella, A.. - (2012). (XXXIV CONVEGNO NAZIONALE DIVISIONE DI CHIMICA ORGANICA Pavia 10-14 settembre).
Theonella swinhoei as a source of anti-inflammatory cyclopeptides
FESTA, CARMEN;DE MARINO, SIMONA;D'AURIA, MARIA VALERIA;M. C. Monti;BUCCI, MARIAROSARIA;VELLECCO, VALENTINA;ZAMPELLA, ANGELA
2012
Abstract
As a part of our systematic study on secondary metabolites from marine organisms collected at Solomon Islands, we found a single specimen of the sponge Theonella swinhoei as an extraordinary source of anti-inflammatory cyclic cyclopeptides, such as perthamides C-K and solomonamides. Perthamides C-K are endowed of promising anti-inflammatory activity. The isolation of this small library of peptides allowed us to delineate a structure-activity relationship.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
