IRIS
FRECENTESE, FRANCESCO
 Distribuzione geografica
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Continente #
AS - Asia 3.834
EU - Europa 3.625
NA - Nord America 3.401
SA - Sud America 442
AF - Africa 142
Continente sconosciuto - Info sul continente non disponibili 3
OC - Oceania 3
Totale 11.450
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Nazione #
US - Stati Uniti d'America 3.268
SG - Singapore 1.662
RU - Federazione Russa 1.329
IT - Italia 1.040
CN - Cina 779
VN - Vietnam 729
DE - Germania 370
BR - Brasile 357
HK - Hong Kong 263
FR - Francia 204
NL - Olanda 137
FI - Finlandia 114
GB - Regno Unito 91
CA - Canada 81
IE - Irlanda 79
JP - Giappone 75
IN - India 73
CI - Costa d'Avorio 54
BD - Bangladesh 52
UA - Ucraina 52
ES - Italia 40
PL - Polonia 33
GR - Grecia 32
ZA - Sudafrica 29
MX - Messico 28
AR - Argentina 27
KR - Corea 27
SE - Svezia 26
AT - Austria 22
MA - Marocco 22
PH - Filippine 20
ID - Indonesia 19
EC - Ecuador 18
TH - Thailandia 18
IQ - Iraq 16
TR - Turchia 16
PK - Pakistan 13
BG - Bulgaria 11
TN - Tunisia 11
CO - Colombia 10
JO - Giordania 10
VE - Venezuela 10
IL - Israele 9
LT - Lituania 8
EG - Egitto 7
PY - Paraguay 7
SA - Arabia Saudita 7
TW - Taiwan 7
UZ - Uzbekistan 7
CH - Svizzera 5
CL - Cile 5
JM - Giamaica 4
MY - Malesia 4
NI - Nicaragua 4
SK - Slovacchia (Repubblica Slovacca) 4
UY - Uruguay 4
AZ - Azerbaigian 3
BE - Belgio 3
DZ - Algeria 3
EE - Estonia 3
EU - Europa 3
GE - Georgia 3
GT - Guatemala 3
HU - Ungheria 3
KE - Kenya 3
LB - Libano 3
LV - Lettonia 3
SI - Slovenia 3
AE - Emirati Arabi Uniti 2
AL - Albania 2
AM - Armenia 2
AO - Angola 2
AU - Australia 2
BO - Bolivia 2
CZ - Repubblica Ceca 2
DO - Repubblica Dominicana 2
GA - Gabon 2
GY - Guiana 2
HT - Haiti 2
IR - Iran 2
KG - Kirghizistan 2
MD - Moldavia 2
MG - Madagascar 2
NO - Norvegia 2
PS - Palestinian Territory 2
PT - Portogallo 2
SV - El Salvador 2
SY - Repubblica araba siriana 2
TT - Trinidad e Tobago 2
BA - Bosnia-Erzegovina 1
BS - Bahamas 1
CD - Congo 1
CM - Camerun 1
CR - Costa Rica 1
CU - Cuba 1
CY - Cipro 1
DM - Dominica 1
HN - Honduras 1
HR - Croazia 1
KH - Cambogia 1
Totale 11.438
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Città #
Singapore 812
San Jose 580
Naples 314
Moscow 304
Chandler 281
Beijing 259
Ashburn 245
Hong Kong 245
Ho Chi Minh City 200
Hanoi 165
Santa Clara 152
Hefei 139
Amsterdam 106
The Dalles 85
Napoli 84
Lauterbourg 80
Los Angeles 80
Millbury 79
Menlo Park 76
Munich 59
Tokyo 56
Council Bluffs 49
Nanjing 47
Krefeld 46
Princeton 44
New York 43
Jacksonville 41
São Paulo 38
Boston 37
Des Moines 37
Dallas 35
Redondo Beach 35
Buffalo 34
Frankfurt am Main 34
Helsinki 32
Haiphong 30
Ottawa 30
Turku 28
Woodbridge 28
Milan 27
Falkenstein 26
Houston 26
Rome 26
Lawrence 25
Bad Bellingen 24
Da Nang 24
Seoul 23
Toronto 23
Wilmington 23
Brooklyn 22
Dong Ket 20
Pozzuoli 20
Thessaloniki 20
Orem 19
Warsaw 19
Casablanca 17
Nuremberg 17
San Giorgio a Cremano 17
Redwood City 16
Atlanta 15
Mexico City 15
Nanchang 15
Chicago 14
Johannesburg 14
San Francisco 14
Chennai 13
Hải Dương 13
Montreal 13
Dublin 12
Phoenix 12
Seattle 12
Vienna 12
Athens 11
Dearborn 11
Denver 11
London 11
Mugnano di Napoli 11
Rio de Janeiro 11
Salerno 11
Cambridge 10
Hebei 10
Manchester 10
Stockholm 10
Cervino 9
Lappeenranta 9
Sofia 9
Trieste 9
Amman 8
Frisco 8
Jiaxing 8
Mumbai 8
Poplar 8
Bangkok 7
Can Tho 7
Coimbatore 7
Curitiba 7
New Delhi 7
Norwalk 7
Quận Ba 7
Roccarainola 7
Totale 5.926
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Nome #
1,2,4-Thiadiazolidin-3,5-diones as novel hydrogen sulfide donors 360
Design, Synthesis and Biological Evaluation of Novel N-Arylpiperazines Containing a 4,5-Dihydrothiazole Ring 302
Development of 1,2,3-Triazole-Based Sphingosine Kinase Inhibitors and Their Evaluation as Antiproliferative Agents 197
Chemical Composition of PM10 at Urban Sites in Naples (Italy) 184
Synthesis of phenylpyrimidinones as guanylyl cyclase C inhibitors 180
Design of Sphingosine Kinases Inhibitors: Challenges and Recent Developments 171
MONTELUKAST ESTERS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME 171
Antagonizing S1P3 receptor with cell-penetrating pepducins in skeletal muscle fibrosis 168
Identification of a pepducin acting as S1P3 receptor antagonist 167
Heavy Metals Size Distribution in PM10 and Environmental-Sanitary Risk Analysis in Acerra (Italy) 163
Synthesis, in vitro and in vivo pharmacological evaluation of serotoninergic ligands containing an isonicotinic nucleus 160
Synthesis and in Vitro Screening of New Series of 2,6-Dipeptidyl-anthraquinones: Influence of Side Chain Length on HIV-1 Nucleocapsid Inhibitors 159
The Role of 5-HT1A Receptor in the Cancer as a New Opportunity in Medicinal Chemistry 158
Synthesis, docking studies, and pharmacological evaluation of 5HT 2C ligands containing the N′-cyanoisonicotinamidine or N′-cyanopicolinamidine nucleus 155
New 5-HT1A, 5HT2Aand 5HT2Creceptor ligands containing a picolinic nucleus: Synthesis, in vitro and in vivo pharmacological evaluation 154
HYBRIDS BETWEEN H2S-DONORS AND BETAMETHASONE 17-VALERATE OR TRIAMCINOLONE ACETONIDE: IN VITRO EFFECT IN ASTHMA TREATMENT 154
Synthesis of Arylpiperazine Derivatives as Protease Activated Receptor 1 Antagonists and Their Evaluation as Antiproliferative Agents 153
Synthesis and Pharmacological Screening of Pyridopyrimidines as Effective Anti-Diarrheal Agents through the Suppression of Cyclic Nucleotide Accumulation 151
Synthesis, Chiral Resolution and Enantiomers Absolute Configuration of 4-Nitropropranolol and 7-Nitropropranolol 150
Non-Natural Linker Configuration in 2,6-Dipeptidyl-Anthraquinones Enhances the Inhibition of TAR RNA Binding/Annealing Activities by HIV-1 NC and Tat Proteins 149
A New Process for the Synthesis of Budesonide 21-Phosphate and Evaluation in a Murine Model of Inflammation 148
Synthesis, Biological Evaluation and Docking Studies of PAR2-AP Derived Pseudopeptides as Inhibitors of Kallikrein 5 and 6 145
Development validation of LC-MS/MS method and determination of pharmacokinetic parameters of the stroke neuroprotectant neurounina-1 in beagle dog plasma after intravenous administration 145
Isothiocyanate-Corticosteroid Conjugates against asthma: Unity makes strength 143
Hybrids between H2S-donors and betamethasone 17-valerate or triamcinolone acetonide inhibit mast cell degranulation and promote hyperpolarization of bronchial smooth muscle cells 143
5‑HT1A Receptor: An Old Target as a New Attractive Tool in Drug Discovery from Central Nervous System to Cancer 142
Level, potential sources of polycyclic aromatic hydrocarbons (PAHs) in particulate matter (PM10) in Naples 142
New Potent 5-HT2A Receptor Ligands Containing a N'-Cyanopicolinamidine Nucleus: Synthesis and In Vitro Pharmacological Evaluation 141
Lipophilic and polar interaction forces between acidic drugs and membrane phospholipids encoded in IAM-HPLC indexes: their role in membrane partition and relationships with BBB permeation data. 140
Design, synthesis and biological evaluation of TAR and cTAR binders as HIV-​1 nucleocapsid inhibitors 140
Genetic Up-Regulation or Pharmacological Activation of the Na+/Ca2+ Exchanger 1 (NCX1) Enhances Hippocampal-Dependent Contextual and Spatial Learning and Memory 139
PCB levels in adipose tissue of dogs from illegal dumping sites in Campania region (Italy) 139
Microwave Assisted Organic Synthesis of Heterocycles in Aqueous Media: Recent Advances in Medicinal Chemistry 138
3-Nitroatenolol: First Synthesis, Chiral Resolution and Enantiomers’ Absolute Configuration 137
Synthesis and In Vitro Pharmacological Evaluation of Novel 2-Hydroxypropyl-4-arylpiperazine Derivatives as Serotoninergic Ligands 137
New Serotoninergic Ligands Containing Indolic and Methyl Indolic Nuclei: Synthesis and In Vitro Pharmacological Evaluation 135
Novel tools for the elucidation of physio-pathological role of H2S 134
Newly Synthesized Indolylacetic Derivatives Reduce Tumor Necrosis Factor-Mediated Neuroinflammation and Prolong Survival in Amyotrophic Lateral Sclerosis Mice 133
Synthesis, Docking Studies and Pharmacological Evaluation of Serotoninergic Ligands Containing a 5-Norbornene-2-Carboxamide Nucleus 130
The Application of Microwaves, Ultrasounds, and Their Combination in the Synthesis of Nitrogen-Containing Bicyclic Heterocycles 128
Anti-metastatic properties of naproxen-HBTA in a murine model of cutaneous melanoma 128
Prolonged NCX activation prevents SOD1 accumulation, reduces neuroinflammation, ameliorates motor behavior and prolongs survival in a ALS mouse model 128
Synthesis of benzamide derivatives and their evaluation as antiprion agents 126
Involvement of 3′,5′-cyclic inosine monophosphate in cystathionine γ-lyase-dependent regulation of the vascular tone 126
Budesonide 21-phosphate sodium salt for use as anti-inflammatory or anti-asthmatic agent. 124
Arylpiperazine Derivatives and Cancer: A New Challenge in Medicinal Chemistry 124
Synthesis of 1-naphthylpiperazine derivatives as serotoninergic ligands and their evaluation as antiproliferative agents. 122
BUDESONIDE 21-PHOSPHATE SALTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME 122
H2s donors and their use in medicinal chemistry 122
Racemic synthesis and solid phase peptide synthesis application of the chimeric Valine/Leucine derivative 2-amino-3,3,4-trimethyl-pentanoic acid 121
Design, Synthesis and Evaluation of Novel Molecular Hybrids between Antiglaucoma Drugs and H2S Donors 119
A valuable synthesis of reduced peptide bond by microwave irradiation 118
Structure-activity relationships study of isothiocyanates for H2S releasing properties: 3-Pyridyl-isothiocyanate as a new promising cardioprotective agent 118
Technological and Physical–Chemical Evaluation of Cotton Gauzes Impregnated with Semisolid Preparations for Wound Healing 117
Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide production 117
Quantification of dapaconazole in human plasma using high-​performance liquid chromatography coupled to tandem mass spectrometry: Application to a phase I study 115
Trends in h2s-donors chemistry and their effects in cardiovascular diseases 115
Identification of a novel selective CSE inhibitor through a combined pharmacological and metabolomic approach 114
Synthesis of Nα-Fmoc N,N′-bis-Boc-5-, 6- and 8-guanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid (5-GTIC, 6-GTIC and 8-GTIC) 112
Sintesi e caratterizzazione farmacologica di nuovi chemioterapici antitumorali inibitori della farnesil-transferasi 112
Kallikrein Protease Activated Receptor (PAR) Axis: An Attractive Target for Drug Development 111
Synthesis, docking studies, and pharmacological evaluation of 2-hydroxypropyl-4-arylpiperazine derivatives as serotoninergic ligands 111
Multiple in Vitro Inhibition of HIV-1 Proteins by 2,6-Dipeptidyl-anthraquinone Conjugates Targeting the PBS RNA 109
Propylthiouracil quantification in human plasma by high-​performance liquid chromatography coupled with electrospray tandem mass spectrometry: Application in a bioequivalence study 108
Microwave Solvent Free Regioselective 1,3 Dipolar Cycloaddition in the Synthesis of 1,4 Substituted [1,2,3]-Triazoles as Amide Bond Isosteres 107
H2S donating corticosteroids: Design, synthesis and biological evaluation in a murine model of asthma 107
Enhanced efficacy of formoterol-montelukast salt in relieving asthma features and in preserving β2-agonists rescue therapy 106
Development and evaluation of nanostructured systems for cutaneous delivery of H2S-releasing corticosteroids for skin inflammatory diseases 105
Inhibition of rat vas deferens contractions by flavonoids in-vitro 105
Eco-friendly Synthesis and Molecular Modelling of 2-Phenylimidazo[1,2-b]pyridazine Derivatives: In Vitro and In Vivo Studies for Lead Optimization 105
The identification of adenylyl cyclase modulators as potential receptors for 6-nitrodopamine in human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes and their relevance in heart inotropism 104
A suitable 1,2,4-oxadiazoles synthesis by microwave irradiation 103
Efficient Microwave Combinatorial Parallel and Non Parallel Synthesis of N-Alkylated Glycine Methyl Esters as Peptide Building Blocks 99
Synthesis of 6-beta-D-glucosyl and 6-nitroxy (-)-galanthamine derivatives as acetylcholinesterase inhibitors 99
Measurement of 6‐cyanodopamine, 6‐nitrodopa, 6‐nitrodopamine and 6‐nitroadrenaline by LC–MS/MS in Krebs–Henseleit solution. Assessment of basal release from rabbit isolated right atrium and ventricles 95
New Insights into the Structure-Activity Relationship and Neuroprotective Profile of Benzodiazepinone Derivatives of Neurounina-1 as Modulators of the Na+/Ca2+Exchanger Isoforms 95
Montelukast salts and pharmaceutical compositions containing the same 92
Efficient microwave combinatorial synthesis of novel indolic arylpiperazine derivatives as serotoninergic ligands 85
Design and synthesis of potential b-sheet nucleatorsvia Suzuki coupling reaction 81
GKT137831 and hydrogen peroxide increase the release of 6-nitrodopamine from the human umbilical artery, rat-isolated right atrium, and rat-isolated vas deferens 77
Process for the preparation of budesonide 21-phosphate 76
Synthesis and in vitro pharmacological evaluation of a new series of 5-HT1A 5-HT2A and 5-HT2C receptor ligands containing a norbornene nucleus. 74
Microwave Assisted Synthesis: A New Technology in Drug Discovery 73
The application of microwaves in combinatorial and high-throughput synthesis as new synthetic procedure in drug discovery. 69
Synthesis and pharmacological evaluation of peptide-mimetic protease-activated receptor-1 antagonists containing novel heterocyclic scaffolds 68
Synthesis by microwave irradiation and antidiarrhoeal activity of benzotriazinone and saccharine derivatives. 65
Multifaceted Aspects of HIV-1 Nucleocapsid Inhibition by TAR-Targeting Peptidyl-Anthraquinones Bearing Terminal Aromatic Moieties 64
New 5-HT(1A) receptor ligands containing a N'-cyanoisonicotinamidine nucleus: Synthesis and in vitro pharmacological evaluation 63
Efficient microwave-assisted synthesis of 4-amino-2-benzazepin-3-ones as conformationally restricted dipeptide mimetics 58
Synthesis and Pharmacological Evaluations of Sildenafil Analogues for Treatment of Erectile Dysfunction. 57
Quantification of estradiol cypionate in plasma by liquid chromatography coupled with tandem mass spectrometry: Application in a pharmacokinetic study in healthy female volunteers 57
Recent Advances in Synthesis of PAR Ligands as Therapeutic Strategy for Inflammatory Diseases 55
Synthesis and in-vitro pharmacological evaluation of new 5-HT1A receptor ligands containing a benzotriazinone nucleus 45
Novel 1,4-benzothiazepin-2-one modulators of NCX3 as a promising strategy for neuroprotection in cerebral ischemia 28
1,2,4-Thiadiazolidin-3,5-Diones as Inhibitors of Cysteine Proteases 20
Improved Synthesis of 5-Nitrohomovanillic Acid and 6-Nitrohomovanillic Acid as Probes for Metabolism Studies of Endothelium-Derived Dopamines: Identification in Human Amniotic Fluid 15
Totale 11.676
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Categoria #
all - tutte 35.662
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 35.662
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202137 0 0 0 0 0 0 0 0 0 0 0 37
2021/2022656 3 3 5 146 16 28 2 25 63 60 129 176
2022/2023706 84 92 18 54 61 67 15 56 101 90 47 21
2023/2024736 24 83 114 21 17 18 41 65 205 18 84 46
2024/20253.034 128 168 40 66 78 210 280 213 185 331 1.089 246
2025/20265.440 570 402 615 460 900 180 649 297 759 379 194 35
Totale 11.676