IRIS
FRECENTESE, FRANCESCO
 Distribuzione geografica
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Continente #
EU - Europa 3.385
AS - Asia 2.860
NA - Nord America 2.272
SA - Sud America 401
AF - Africa 125
Continente sconosciuto - Info sul continente non disponibili 3
OC - Oceania 2
Totale 9.048
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Nazione #
US - Stati Uniti d'America 2.170
SG - Singapore 1.563
RU - Federazione Russa 1.327
IT - Italia 947
CN - Cina 713
DE - Germania 354
BR - Brasile 333
HK - Hong Kong 234
VN - Vietnam 145
NL - Olanda 129
FR - Francia 121
FI - Finlandia 114
IE - Irlanda 77
GB - Regno Unito 75
CA - Canada 59
CI - Costa d'Avorio 54
UA - Ucraina 50
IN - India 45
ES - Italia 36
GR - Grecia 32
JP - Giappone 31
PL - Polonia 28
SE - Svezia 26
AR - Argentina 24
KR - Corea 23
ZA - Sudafrica 23
MA - Marocco 22
MX - Messico 22
AT - Austria 20
BD - Bangladesh 16
EC - Ecuador 16
ID - Indonesia 15
BG - Bulgaria 11
IQ - Iraq 10
TN - Tunisia 8
TR - Turchia 8
CO - Colombia 7
LT - Lituania 7
PK - Pakistan 7
PY - Paraguay 7
JO - Giordania 6
SA - Arabia Saudita 5
UZ - Uzbekistan 5
EG - Egitto 4
IL - Israele 4
MY - Malesia 4
NI - Nicaragua 4
SK - Slovacchia (Repubblica Slovacca) 4
UY - Uruguay 4
VE - Venezuela 4
AZ - Azerbaigian 3
BE - Belgio 3
CH - Svizzera 3
EE - Estonia 3
EU - Europa 3
JM - Giamaica 3
LB - Libano 3
LV - Lettonia 3
AE - Emirati Arabi Uniti 2
AL - Albania 2
AO - Angola 2
BO - Bolivia 2
CL - Cile 2
CZ - Repubblica Ceca 2
DO - Repubblica Dominicana 2
GE - Georgia 2
GT - Guatemala 2
GY - Guiana 2
HT - Haiti 2
HU - Ungheria 2
IR - Iran 2
KE - Kenya 2
KG - Kirghizistan 2
MG - Madagascar 2
NO - Norvegia 2
PH - Filippine 2
PT - Portogallo 2
SI - Slovenia 2
SV - El Salvador 2
AM - Armenia 1
AU - Australia 1
BA - Bosnia-Erzegovina 1
BS - Bahamas 1
CD - Congo 1
CM - Camerun 1
CR - Costa Rica 1
CU - Cuba 1
CY - Cipro 1
DM - Dominica 1
DZ - Algeria 1
GA - Gabon 1
HN - Honduras 1
KH - Cambogia 1
KW - Kuwait 1
KZ - Kazakistan 1
LA - Repubblica Popolare Democratica del Laos 1
LK - Sri Lanka 1
MD - Moldavia 1
MN - Mongolia 1
MZ - Mozambico 1
Totale 9.040
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Città #
Singapore 742
Moscow 304
Naples 282
Chandler 280
Beijing 249
Hong Kong 234
Ashburn 171
Santa Clara 144
Hefei 139
Amsterdam 101
Napoli 84
Millbury 79
Menlo Park 76
Los Angeles 66
Munich 59
Ho Chi Minh City 49
Nanjing 47
Krefeld 46
Princeton 44
Jacksonville 41
Des Moines 37
Redondo Beach 35
Boston 34
Helsinki 32
São Paulo 32
Ottawa 30
Buffalo 29
Turku 28
Woodbridge 28
Hanoi 27
Falkenstein 26
Lawrence 25
Bad Bellingen 24
Frankfurt am Main 23
Seoul 23
Wilmington 23
Milan 22
New York 22
Tokyo 21
Dong Ket 20
Houston 20
Pozzuoli 20
Thessaloniki 20
Brooklyn 19
Rome 19
Casablanca 17
Dallas 17
San Giorgio a Cremano 17
Nuremberg 16
Redwood City 16
The Dalles 16
Nanchang 15
Toronto 15
Warsaw 14
Mexico City 12
San Francisco 12
Vienna 12
Athens 11
Chicago 11
Dearborn 11
Mugnano di Napoli 11
Seattle 11
Cambridge 10
Dublin 10
Hebei 10
Salerno 10
Stockholm 10
Cervino 9
Chennai 9
Haiphong 9
Johannesburg 9
Lappeenranta 9
Phoenix 9
Rio de Janeiro 9
Sofia 9
Trieste 9
Atlanta 8
Denver 8
Jiaxing 8
London 8
Manchester 8
Curitiba 7
Montreal 7
New Delhi 7
Roccarainola 7
Scunthorpe 7
Zola Predosa 7
Amman 6
Council Bluffs 6
Da Nang 6
Düsseldorf 6
Ercolano 6
Falcone 6
Guangzhou 6
Indiana 6
Jena 6
Krakow 6
Manaus 6
Norwalk 6
Orem 6
Totale 4.401
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Nome #
1,2,4-Thiadiazolidin-3,5-diones as novel hydrogen sulfide donors 321
Design, Synthesis and Biological Evaluation of Novel N-Arylpiperazines Containing a 4,5-Dihydrothiazole Ring 272
Chemical Composition of PM10 at Urban Sites in Naples (Italy) 153
Development of 1,2,3-Triazole-Based Sphingosine Kinase Inhibitors and Their Evaluation as Antiproliferative Agents 153
MONTELUKAST ESTERS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME 150
Design of Sphingosine Kinases Inhibitors: Challenges and Recent Developments 142
Synthesis of phenylpyrimidinones as guanylyl cyclase C inhibitors 140
Heavy Metals Size Distribution in PM10 and Environmental-Sanitary Risk Analysis in Acerra (Italy) 138
Antagonizing S1P3 receptor with cell-penetrating pepducins in skeletal muscle fibrosis 133
Synthesis of Arylpiperazine Derivatives as Protease Activated Receptor 1 Antagonists and Their Evaluation as Antiproliferative Agents 129
Synthesis, Chiral Resolution and Enantiomers Absolute Configuration of 4-Nitropropranolol and 7-Nitropropranolol 127
Synthesis and in Vitro Screening of New Series of 2,6-Dipeptidyl-anthraquinones: Influence of Side Chain Length on HIV-1 Nucleocapsid Inhibitors 126
New 5-HT1A, 5HT2Aand 5HT2Creceptor ligands containing a picolinic nucleus: Synthesis, in vitro and in vivo pharmacological evaluation 126
The Role of 5-HT1A Receptor in the Cancer as a New Opportunity in Medicinal Chemistry 123
Identification of a pepducin acting as S1P3 receptor antagonist 122
Synthesis and Pharmacological Screening of Pyridopyrimidines as Effective Anti-Diarrheal Agents through the Suppression of Cyclic Nucleotide Accumulation 122
Synthesis, in vitro and in vivo pharmacological evaluation of serotoninergic ligands containing an isonicotinic nucleus 121
HYBRIDS BETWEEN H2S-DONORS AND BETAMETHASONE 17-VALERATE OR TRIAMCINOLONE ACETONIDE: IN VITRO EFFECT IN ASTHMA TREATMENT 121
Non-Natural Linker Configuration in 2,6-Dipeptidyl-Anthraquinones Enhances the Inhibition of TAR RNA Binding/Annealing Activities by HIV-1 NC and Tat Proteins 120
Development validation of LC-MS/MS method and determination of pharmacokinetic parameters of the stroke neuroprotectant neurounina-1 in beagle dog plasma after intravenous administration 117
Hybrids between H2S-donors and betamethasone 17-valerate or triamcinolone acetonide inhibit mast cell degranulation and promote hyperpolarization of bronchial smooth muscle cells 117
A New Process for the Synthesis of Budesonide 21-Phosphate and Evaluation in a Murine Model of Inflammation 115
Level, potential sources of polycyclic aromatic hydrocarbons (PAHs) in particulate matter (PM10) in Naples 115
Synthesis, docking studies, and pharmacological evaluation of 5HT 2C ligands containing the N′-cyanoisonicotinamidine or N′-cyanopicolinamidine nucleus 113
3-Nitroatenolol: First Synthesis, Chiral Resolution and Enantiomers’ Absolute Configuration 112
Microwave Assisted Organic Synthesis of Heterocycles in Aqueous Media: Recent Advances in Medicinal Chemistry 112
Anti-metastatic properties of naproxen-HBTA in a murine model of cutaneous melanoma 112
Synthesis, Biological Evaluation and Docking Studies of PAR2-AP Derived Pseudopeptides as Inhibitors of Kallikrein 5 and 6 111
Genetic Up-Regulation or Pharmacological Activation of the Na+/Ca2+ Exchanger 1 (NCX1) Enhances Hippocampal-Dependent Contextual and Spatial Learning and Memory 111
Budesonide 21-phosphate sodium salt for use as anti-inflammatory or anti-asthmatic agent. 110
Isothiocyanate-Corticosteroid Conjugates against asthma: Unity makes strength 110
Synthesis and In Vitro Pharmacological Evaluation of Novel 2-Hydroxypropyl-4-arylpiperazine Derivatives as Serotoninergic Ligands 108
New Potent 5-HT2A Receptor Ligands Containing a N'-Cyanopicolinamidine Nucleus: Synthesis and In Vitro Pharmacological Evaluation 106
5‑HT1A Receptor: An Old Target as a New Attractive Tool in Drug Discovery from Central Nervous System to Cancer 106
The Application of Microwaves, Ultrasounds, and Their Combination in the Synthesis of Nitrogen-Containing Bicyclic Heterocycles 104
Synthesis, Docking Studies and Pharmacological Evaluation of Serotoninergic Ligands Containing a 5-Norbornene-2-Carboxamide Nucleus 104
Novel tools for the elucidation of physio-pathological role of H2S 104
Prolonged NCX activation prevents SOD1 accumulation, reduces neuroinflammation, ameliorates motor behavior and prolongs survival in a ALS mouse model 104
Design, synthesis and biological evaluation of TAR and cTAR binders as HIV-​1 nucleocapsid inhibitors 103
H2s donors and their use in medicinal chemistry 103
PCB levels in adipose tissue of dogs from illegal dumping sites in Campania region (Italy) 102
A valuable synthesis of reduced peptide bond by microwave irradiation 101
New Serotoninergic Ligands Containing Indolic and Methyl Indolic Nuclei: Synthesis and In Vitro Pharmacological Evaluation 101
Newly Synthesized Indolylacetic Derivatives Reduce Tumor Necrosis Factor-Mediated Neuroinflammation and Prolong Survival in Amyotrophic Lateral Sclerosis Mice 101
Synthesis of benzamide derivatives and their evaluation as antiprion agents 100
Lipophilic and polar interaction forces between acidic drugs and membrane phospholipids encoded in IAM-HPLC indexes: their role in membrane partition and relationships with BBB permeation data. 100
Racemic synthesis and solid phase peptide synthesis application of the chimeric Valine/Leucine derivative 2-amino-3,3,4-trimethyl-pentanoic acid 100
Structure-activity relationships study of isothiocyanates for H2S releasing properties: 3-Pyridyl-isothiocyanate as a new promising cardioprotective agent 99
BUDESONIDE 21-PHOSPHATE SALTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME 99
Synthesis of Nα-Fmoc N,N′-bis-Boc-5-, 6- and 8-guanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid (5-GTIC, 6-GTIC and 8-GTIC) 96
Involvement of 3′,5′-cyclic inosine monophosphate in cystathionine γ-lyase-dependent regulation of the vascular tone 95
Quantification of dapaconazole in human plasma using high-​performance liquid chromatography coupled to tandem mass spectrometry: Application to a phase I study 94
Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide production 94
Technological and Physical–Chemical Evaluation of Cotton Gauzes Impregnated with Semisolid Preparations for Wound Healing 93
Trends in h2s-donors chemistry and their effects in cardiovascular diseases 93
Identification of a novel selective CSE inhibitor through a combined pharmacological and metabolomic approach 92
Design, Synthesis and Evaluation of Novel Molecular Hybrids between Antiglaucoma Drugs and H2S Donors 91
Microwave Solvent Free Regioselective 1,3 Dipolar Cycloaddition in the Synthesis of 1,4 Substituted [1,2,3]-Triazoles as Amide Bond Isosteres 91
Synthesis of 1-naphthylpiperazine derivatives as serotoninergic ligands and their evaluation as antiproliferative agents. 91
Synthesis, docking studies, and pharmacological evaluation of 2-hydroxypropyl-4-arylpiperazine derivatives as serotoninergic ligands 91
Inhibition of rat vas deferens contractions by flavonoids in-vitro 90
Arylpiperazine Derivatives and Cancer: A New Challenge in Medicinal Chemistry 89
Enhanced efficacy of formoterol-montelukast salt in relieving asthma features and in preserving β2-agonists rescue therapy 89
Sintesi e caratterizzazione farmacologica di nuovi chemioterapici antitumorali inibitori della farnesil-transferasi 88
A suitable 1,2,4-oxadiazoles synthesis by microwave irradiation 87
H2S donating corticosteroids: Design, synthesis and biological evaluation in a murine model of asthma 87
Propylthiouracil quantification in human plasma by high-​performance liquid chromatography coupled with electrospray tandem mass spectrometry: Application in a bioequivalence study 86
Kallikrein Protease Activated Receptor (PAR) Axis: An Attractive Target for Drug Development 83
New Insights into the Structure-Activity Relationship and Neuroprotective Profile of Benzodiazepinone Derivatives of Neurounina-1 as Modulators of the Na+/Ca2+Exchanger Isoforms 83
Measurement of 6‐cyanodopamine, 6‐nitrodopa, 6‐nitrodopamine and 6‐nitroadrenaline by LC–MS/MS in Krebs–Henseleit solution. Assessment of basal release from rabbit isolated right atrium and ventricles 79
Development and evaluation of nanostructured systems for cutaneous delivery of H2S-releasing corticosteroids for skin inflammatory diseases 79
Efficient Microwave Combinatorial Parallel and Non Parallel Synthesis of N-Alkylated Glycine Methyl Esters as Peptide Building Blocks 78
Synthesis of 6-beta-D-glucosyl and 6-nitroxy (-)-galanthamine derivatives as acetylcholinesterase inhibitors 78
Montelukast salts and pharmaceutical compositions containing the same 76
Eco-friendly Synthesis and Molecular Modelling of 2-Phenylimidazo[1,2-b]pyridazine Derivatives: In Vitro and In Vivo Studies for Lead Optimization 76
Multiple in Vitro Inhibition of HIV-1 Proteins by 2,6-Dipeptidyl-anthraquinone Conjugates Targeting the PBS RNA 74
Efficient microwave combinatorial synthesis of novel indolic arylpiperazine derivatives as serotoninergic ligands 72
Synthesis and in vitro pharmacological evaluation of a new series of 5-HT1A 5-HT2A and 5-HT2C receptor ligands containing a norbornene nucleus. 65
Process for the preparation of budesonide 21-phosphate 64
Design and synthesis of potential b-sheet nucleatorsvia Suzuki coupling reaction 64
Microwave Assisted Synthesis: A New Technology in Drug Discovery 57
Multifaceted Aspects of HIV-1 Nucleocapsid Inhibition by TAR-Targeting Peptidyl-Anthraquinones Bearing Terminal Aromatic Moieties 56
New 5-HT(1A) receptor ligands containing a N'-cyanoisonicotinamidine nucleus: Synthesis and in vitro pharmacological evaluation 56
The application of microwaves in combinatorial and high-throughput synthesis as new synthetic procedure in drug discovery. 56
Synthesis and pharmacological evaluation of peptide-mimetic protease-activated receptor-1 antagonists containing novel heterocyclic scaffolds 52
GKT137831 and hydrogen peroxide increase the release of 6-nitrodopamine from the human umbilical artery, rat-isolated right atrium, and rat-isolated vas deferens 48
Synthesis by microwave irradiation and antidiarrhoeal activity of benzotriazinone and saccharine derivatives. 47
Efficient microwave-assisted synthesis of 4-amino-2-benzazepin-3-ones as conformationally restricted dipeptide mimetics 47
Recent Advances in Synthesis of PAR Ligands as Therapeutic Strategy for Inflammatory Diseases 45
Synthesis and Pharmacological Evaluations of Sildenafil Analogues for Treatment of Erectile Dysfunction. 44
Quantification of estradiol cypionate in plasma by liquid chromatography coupled with tandem mass spectrometry: Application in a pharmacokinetic study in healthy female volunteers 43
Synthesis and in-vitro pharmacological evaluation of new 5-HT1A receptor ligands containing a benzotriazinone nucleus 41
The identification of adenylyl cyclase modulators as potential receptors for 6-nitrodopamine in human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes and their relevance in heart inotropism 31
Totale 9.270
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Categoria #
all - tutte 30.082
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 30.082
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021140 0 0 0 0 0 20 27 5 19 8 24 37
2021/2022656 3 3 5 146 16 28 2 25 63 60 129 176
2022/2023706 84 92 18 54 61 67 15 56 101 90 47 21
2023/2024736 24 83 114 21 17 18 41 65 205 18 84 46
2024/20253.034 128 168 40 66 78 210 280 213 185 331 1.089 246
2025/20263.034 570 402 615 460 900 87 0 0 0 0 0 0
Totale 9.270