Several studies have been published on discovering involvement of PARs receptors in a number of disease states, including cancer and inflammation of the cardiovascular, respiratory, musculoskeletal, gastrointestinal and nervous systems. This mini-review will focus on recent advances in the synthesis of PAR ligands highlighting their therapeutic potential in the treatment of various inflammatory diseases.
Recent Advances in Synthesis of PAR Ligands as Therapeutic Strategy for Inflammatory Diseases / Severino, Beatrice; Santagada, Vincenzo; Perissutti, Elisa; Fiorino, Ferdinando; Frecentese, Francesco; F., De Angelis; A., Esposito; Caliendo, Giuseppe. - In: MINI-REVIEWS IN MEDICINAL CHEMISTRY. - ISSN 1389-5575. - STAMPA. - 9:6(2009), pp. 653-663. [10.2174/138955709788452711]
Recent Advances in Synthesis of PAR Ligands as Therapeutic Strategy for Inflammatory Diseases
SEVERINO, BEATRICE;SANTAGADA, VINCENZO;PERISSUTTI, ELISA;FIORINO, FERDINANDO;FRECENTESE, FRANCESCO;CALIENDO, GIUSEPPE
2009
Abstract
Several studies have been published on discovering involvement of PARs receptors in a number of disease states, including cancer and inflammation of the cardiovascular, respiratory, musculoskeletal, gastrointestinal and nervous systems. This mini-review will focus on recent advances in the synthesis of PAR ligands highlighting their therapeutic potential in the treatment of various inflammatory diseases.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
