We designed, synthesized and tested novel 2,6-disubstituted-anthraquinones able to bind dynamic secondary structures of nucleic acids, such as TAR RNA and its reverse transcript cTAR, leading to inhibition of the chaperone activities of the nucleocapsid NCp7, a highly conserved viral protein implied in crucial steps of HIV-1 replication

Design, synthesis and biological evaluation of TAR and cTAR binders as HIV-​1 nucleocapsid inhibitors

FRECENTESE, FRANCESCO;PERISSUTTI, ELISA;SANTAGADA, VINCENZO;CALIENDO, GIUSEPPE;MAGLI, ELISA;CIANO, ANTONIO;
2013

Abstract

We designed, synthesized and tested novel 2,6-disubstituted-anthraquinones able to bind dynamic secondary structures of nucleic acids, such as TAR RNA and its reverse transcript cTAR, leading to inhibition of the chaperone activities of the nucleocapsid NCp7, a highly conserved viral protein implied in crucial steps of HIV-1 replication
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/562633
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