Galanthamine is an alkaloid approved for the treatment of Alzheimer’s disease. In this paper the syntheses and the anticholinesterase activities of new glucosyl and nitroxy derivatives substituted on position 6 are reported. Compounds 2, 3 and 5 presented a percentage of inhibition of 35.22%, 47.48% and 67.89 % respectively

Synthesis of 6-beta-D-glucosyl and 6-nitroxy (-)-galanthamine derivatives as acetylcholinesterase inhibitors

PERISSUTTI, ELISA;FIORINO, FERDINANDO;SEVERINO, BEATRICE;FRECENTESE, FRANCESCO;SANTAGADA, VINCENZO;CALIENDO, GIUSEPPE
2007

Abstract

Galanthamine is an alkaloid approved for the treatment of Alzheimer’s disease. In this paper the syntheses and the anticholinesterase activities of new glucosyl and nitroxy derivatives substituted on position 6 are reported. Compounds 2, 3 and 5 presented a percentage of inhibition of 35.22%, 47.48% and 67.89 % respectively
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11588/111928
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