Sphingosine kinases (SphKs) catalyze the phosphorylation of sphingosine to form the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P). S1P is an important lipid mediator with a wide range of biological functions; it is also involved in a variety of diseases such as inflammatory diseases, Alzheimer's disease and cancer.
Design of Sphingosine Kinases Inhibitors: Challenges and Recent Developments / Magli, E., Corvino, A., Fiorino, F., Frecentese, F., Perissutti, E., Saccone, I., Santagada, V., Caliendo, G., Severino, B.. - In: CURRENT PHARMACEUTICAL DESIGN. - ISSN 1381-6128. - 25:(2019). [10.2174/1381612825666190404115424]
Design of Sphingosine Kinases Inhibitors: Challenges and Recent Developments
Magli, Elisa;Corvino, Angela;Fiorino, Ferdinando;Frecentese, Francesco;Perissutti, Elisa;Saccone, Irene;Santagada, Vincenzo;Caliendo, Giuseppe;Severino, Beatrice
2019
Abstract
Sphingosine kinases (SphKs) catalyze the phosphorylation of sphingosine to form the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P). S1P is an important lipid mediator with a wide range of biological functions; it is also involved in a variety of diseases such as inflammatory diseases, Alzheimer's disease and cancer.File in questo prodotto:
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