Sphingosine kinases (SphKs) catalyze the phosphorylation of sphingosine to form the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P). S1P is an important lipid mediator with a wide range of biological functions; it is also involved in a variety of diseases such as inflammatory diseases, Alzheimer's disease and cancer.
Design of Sphingosine Kinases Inhibitors: Challenges and Recent Developments / Magli, Elisa; Corvino, Angela; Fiorino, Ferdinando; Frecentese, Francesco; Perissutti, Elisa; Saccone, Irene; Santagada, Vincenzo; Caliendo, Giuseppe; Severino, Beatrice. - In: CURRENT PHARMACEUTICAL DESIGN. - ISSN 1381-6128. - 25:(2019). [10.2174/1381612825666190404115424]
Design of Sphingosine Kinases Inhibitors: Challenges and Recent Developments
Magli, Elisa;Corvino, Angela;Fiorino, Ferdinando;Frecentese, Francesco;Perissutti, Elisa;Saccone, Irene;Santagada, Vincenzo;Caliendo, Giuseppe;Severino, Beatrice
2019
Abstract
Sphingosine kinases (SphKs) catalyze the phosphorylation of sphingosine to form the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P). S1P is an important lipid mediator with a wide range of biological functions; it is also involved in a variety of diseases such as inflammatory diseases, Alzheimer's disease and cancer.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
