IRIS
LIMONGELLI, VITTORIO
 Distribuzione geografica
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Continente #
AS - Asia 3.532
NA - Nord America 3.084
EU - Europa 2.670
SA - Sud America 391
AF - Africa 97
Continente sconosciuto - Info sul continente non disponibili 4
OC - Oceania 3
Totale 9.781
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Nazione #
US - Stati Uniti d'America 2.966
SG - Singapore 1.590
RU - Federazione Russa 1.054
VN - Vietnam 708
CN - Cina 618
IT - Italia 609
BR - Brasile 309
DE - Germania 295
HK - Hong Kong 288
FI - Finlandia 170
FR - Francia 111
NL - Olanda 92
GB - Regno Unito 78
IE - Irlanda 68
CA - Canada 67
JP - Giappone 61
SE - Svezia 54
IN - India 53
AR - Argentina 41
UA - Ucraina 38
BD - Bangladesh 33
MX - Messico 29
KR - Corea 28
ZA - Sudafrica 26
CI - Costa d'Avorio 22
IQ - Iraq 19
ES - Italia 18
PH - Filippine 15
PL - Polonia 15
TR - Turchia 15
PK - Pakistan 14
TH - Thailandia 14
TW - Taiwan 14
AT - Austria 13
CH - Svizzera 13
ID - Indonesia 12
MA - Marocco 10
EC - Ecuador 8
MY - Malesia 7
PY - Paraguay 7
VE - Venezuela 7
CL - Cile 6
LT - Lituania 6
NG - Nigeria 6
AL - Albania 5
BE - Belgio 5
CO - Colombia 5
CZ - Repubblica Ceca 5
EG - Egitto 5
IL - Israele 5
TN - Tunisia 5
JM - Giamaica 4
JO - Giordania 4
KE - Kenya 4
KZ - Kazakistan 4
OM - Oman 4
PS - Palestinian Territory 4
SA - Arabia Saudita 4
UY - Uruguay 4
AZ - Azerbaigian 3
CG - Congo 3
DZ - Algeria 3
ET - Etiopia 3
MT - Malta 3
NP - Nepal 3
PA - Panama 3
SI - Slovenia 3
SN - Senegal 3
TT - Trinidad e Tobago 3
AE - Emirati Arabi Uniti 2
AO - Angola 2
AU - Australia 2
BB - Barbados 2
BY - Bielorussia 2
CR - Costa Rica 2
EU - Europa 2
GA - Gabon 2
HN - Honduras 2
IR - Iran 2
LB - Libano 2
MQ - Martinica 2
PE - Perù 2
RO - Romania 2
A1 - Anonimo 1
BG - Bulgaria 1
BN - Brunei Darussalam 1
DK - Danimarca 1
EE - Estonia 1
GE - Georgia 1
GF - Guiana Francese 1
GR - Grecia 1
GT - Guatemala 1
GU - Guam 1
GY - Guiana 1
KH - Cambogia 1
KN - Saint Kitts e Nevis 1
LA - Repubblica Popolare Democratica del Laos 1
LU - Lussemburgo 1
MD - Moldavia 1
MK - Macedonia 1
Totale 9.769
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Città #
Singapore 708
San Jose 569
Hong Kong 277
Ashburn 273
Moscow 254
Chandler 230
Munich 218
Ho Chi Minh City 204
Beijing 185
Naples 160
Hanoi 143
Santa Clara 117
Helsinki 98
Millbury 98
Dallas 83
Napoli 83
Los Angeles 80
Lauterbourg 79
The Dalles 78
Hefei 76
Amsterdam 74
Nanjing 60
Princeton 60
Tokyo 49
New York 47
Boston 45
Des Moines 44
Buffalo 40
Ottawa 40
Jacksonville 38
Seattle 36
Redondo Beach 31
Wilmington 28
Da Nang 27
Lawrence 26
Haiphong 25
São Paulo 23
Pune 18
Nanchang 17
Brooklyn 16
Chicago 15
Seoul 15
Stockholm 15
Atlanta 14
Houston 14
Mexico City 14
Turku 14
Denver 13
Rome 13
Dong Ket 12
Hebei 12
London 12
Nuremberg 12
Quận Ba 12
Tianjin 12
Torre Annunziata 12
Warsaw 12
Woodbridge 12
Frankfurt am Main 11
Orem 11
Shenyang 11
Angri 10
Biên Hòa 10
Hải Dương 10
Milan 10
Montreal 10
Phoenix 10
Can Tho 9
Jiaxing 9
Johannesburg 9
Manchester 9
Poplar 9
Ankara 8
Baghdad 8
Boardman 8
Falkenstein 8
San Francisco 8
Changsha 7
Council Bluffs 7
Dhaka 7
Dublin 7
Long Xuyen 7
Perugia 7
Phủ Lý 7
Rio de Janeiro 7
Sagrado 7
Salerno 7
Điện Bàn 7
Belo Horizonte 6
Brasília 6
Chennai 6
Curitiba 6
Formia 6
Jyväskylä 6
Bologna 5
Brussels 5
Bến Tre 5
Campinas 5
Cape Town 5
Charlotte 5
Totale 5.313
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Nome #
Discovery of UDCA derivatives as new modulators of bile acid receptors 297
Potent dual agonists of nuclear and membrane bile acid receptors 272
Structural and conformational requisites in DNA quadruplex groove binding: Another piece to the puzzle 194
Design, synthesis and pharmacological characterization of novel potent nonsteroidal agonists of the farnesoid X receptor 178
Discovery of a Novel Class of Dual GPBAR1 Agonists-RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders 177
Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury 170
Ligand binding to telomeric G-quadruplex DNA investigated by funnel-metadynamics simulations 169
Discovery of a Potent and Orally Active Dual GPBAR1/CysLT1R Modulator for the Treatment of Metabolic Fatty Liver Disease 168
A New DNA Structural Motif: The G-Triplex 154
Hyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists 151
Marine and semi-sinthetic hydroxystroids as new scaffolds for pregnane X receptor modulation 148
Structural and conformational requisites in DNA quadruplex groove binding: Another piece to the puzzle 145
Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists 144
Synthesis of new isoxazole derivatives as fxr agonists with improved pharmacokinetic properties 144
Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1 142
Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy 140
Discovery of Bile Acid Derivatives as Potent ACE2 Activators by Virtual Screening and Essential Dynamics 140
Computer-Aided Drug Design Unveils the Structural Requisites for Bile Acid Receptors Modulation 139
Identification of cysteinyl-leukotriene-receptor 1 antagonists as ligands for the bile acid receptor GPBAR1 138
Design and synthesis of hyodeoxycholic acid derivatives as GPBAR1 receptor modulators useful in the treatment of colon inflammation 136
Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1 134
Calmodulin-Dependent Kinase II Mediates Vascular Smooth Muscle Cell Proliferation and Is Potentiated by Extracellular Signal Regulated Kinase 128
Incisterols, highly degraded marine sterols, are a new chemotype of PXR agonists 126
Modeling of Cdc25B Dual Specifity Protein Phosphatase Inhibitors: Docking of Ligands and Enzymatic Inhibition Mechanism 125
Breaking the dogma of the metal-coordinating carboxylate group in integrin ligands: introducing hydroxamic acids to the MIDAS to tune potency and selectivity 123
Indolylarylsulfones carrying a heterocyclic tail as very potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors 123
Elucidating the Binding Behavior of Highly Potent COX-2 Selective Inhibitors 121
Ensemble-docking approach on BACE-1: pharmacophore perception and guidelines for drug design 120
Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties 120
Modification on Ursodeoxycholic Acid (UDCA) Scaffold. Discovery of Bile Acid Derivatives As Selective Agonists of Cell-Surface G-Protein Coupled Bile Acid Receptor 1 (GP-BAR1) 117
Minute-timescale free-energy calculations reveal a pseudo-active state in the adenosine A2A receptor activation mechanism 115
The glycan role in the glycopeptide immunogenicity revealed by atomistic simulations and spectroscopic experiments on the multiple sclerosis biomarker CSF114(Glc) 115
Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists 115
Epoxide functionalization on cholane side chains in the identification of G-protein coupled bile acid receptor (GPBAR1) selective agonists 113
Discovery of amine bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 111
GPBAR1 activation by C6-substituted hyodeoxycholane analogues protect against colitis 110
Correction to “Discovery of a Novel Class of Dual GPBAR1 Agonists–RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders” 109
Acetic Acid Aldose Reductase Inhibitors Bearing a Five-Membered Heterocyclic Core with Potent Topical Activity in a Visual Impairment Rat Model. 107
Insight on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges 106
Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors 106
Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation 102
Targeting bile acid receptors: discovery of a potent and selective Farnesoid X receptor agonist as a new lead in the pharmacological approach to liver diseases 102
Design, Synthesis, and Biological Evaluation of Novel Aminobisphosphonates Possessing an in Vivo Antitumor Activity Through a γδ -T Lymphocytes-Mediated Activation Mechanism. 101
Dual binding mode of SC-558 in COX-2: A new frontier in COX inhibition 101
Ligand Binding to Telomeric DNA G-quadruplex through Metadynamics Calculations 100
Dual binding mode of SC-558 in COX-2: A new frontier in COX inhibition 99
Design, Synthesis and Biological Evaluation of Carboxy Analogues of Arginine Methyltransferase Inhibitor 1 (AMI-1) 99
Drug Repurposing on G Protein-Coupled Receptors Using a Computational Profiling Approach 98
Stop Fitan: Antispasmodic Effect of Natural Extract of Chestnut Wood in Guinea Pig Ileum and Proximal Colon Smooth Muscle 98
The G-triplex DNA 97
Membrane charge dependent states of the beta -amyloid fragment A beta (16-35) with differently charged micelle aggregates 96
Design, synthesis and biologicalevaluation of carboxy analogues of arginine methyltransferase 95
Homology Modeling of NR2B Modulatory Domain of NMDA Receptor and Analysis of Ifenprodil Binding. 93
Probing the Charge Capability of the MIDAS: Phosphinic- and Phosphonic Acid Containing Compounds as New Potent allb beta 3 Integrin Antagonists 93
Membrane charge dependent states of the β-amyloid fragment Aβ (16–35) with differently charged micelle aggregates 91
Investigating the mechanism of substrate uptake and release in the glutamate transporter homologue Glt(Ph) through metadynamics simulations. 91
Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands 89
gamma-Glutamyl 16-diaminopropane derivative of vasoactive intestinal peptide: a potent anti-oxidative agent for human epidermoid cancer cells 87
Rational Drug Design of New Selective Modulators of GPBAR1 85
Bioinformatics and Biosimulations as Toolbox for Peptides and Peptidomimetics Design: Where Are We? 84
Accelerating the Calculation of Protein-Ligand Binding Free Energy and Residence Times Using Dynamically Optimized Collective Variables 83
Structural Insight into the Binding Mode of FXR and GPBAR1 Modulators 81
Potent Arylsulfonamide Inhibitors of Tumor Necrosis Factor-alfa Converting Enzyme Able to Reduce Activated Leukocyte Cell Adhesion Molecule Shedding in Cancer Cell Models 80
Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism 80
Identification of quinoline-based compounds with dual activity against CysLT1R and GPBAR1 80
Ethyl 8-Fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as Novel, Highly Potent, and Safe Antianxiety Agent. 79
Discovery of a new class of GPBAR1 modulators 79
Disruption of TFGβ-SMAD3 pathway by the nuclear receptor SHP mediates the antifibrotic activities of BAR704, a novel highly selective FXR ligand 78
Synthesis of new oxadiazole derivatives as potent and selective FXR antagonists 73
Transferring chemical and energetic knowledge between molecular systems with machine learning 72
G-triplex structure and formation propensity 69
Kinetics of protein-ligand unbinding: Predicting pathways, rates, and rate-limiting steps 67
Mechanistic insight into ligand binding to G-quadruplex DNA 66
Ligand binding free-energy calculations with funnel metadynamics 66
Conformational Changes in the Epidermal Growth Factor Receptor: Role of the Transmembrane Domain Investigated by Coarse-Grained MetaDynamics Free Energy Calculations 65
Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane x receptor modulation. 64
DDT - Drug Discovery Tool: a fast and intuitive graphics user interface for Docking and Molecular Dynamics analysis 64
Improving Small-Molecule Force Field Parameters in Ligand Binding Studies 62
The Molecular Mechanism Underlying Ligand Binding to the Membrane-Embedded Site of a G-Protein-Coupled Receptor 62
To bind or not to bind: diagnosing false positives for 1:1 binding to G-Protein 61
International Scientific Collaboration Is Needed to Bridge Science to Society: USERN2020 Consensus Statement 61
Unbinding Kinetics of a p38 MAP Kinase Type II Inhibitor from Metadynamics Simulations 59
Molecular Modeling for Nanomaterial-Biology Interactions: Opportunities, Challenges, and Perspectives 59
Binding of the Anti-FIV Peptide C8 to Differently Charged Membrane Models: From First Docking to Membrane Tubulation 58
Perspectives on High-Throughput Ligand/Protein Docking With Martini MD Simulations 57
Tailoring of integrin ligands: probing the charge capability of the metal ion-dependent adhesion site. 57
Funnel-metadynamics and solution NMR to estimate protein-ligand affinities 55
Steroidal scaffolds as FXR and GPBAR1 ligands: from chemistry to therapeutical application 53
Promoting transparency and reproducibility in enhanced molecular simulations 53
Energetics and structural characterization of the large-scale functional motion of adenylate kinase 52
The Free Energy Landscape of GABA Binding to a Pentameric Ligand-Gated Ion Channel and Its Disruption by Mutations 52
Ligand binding free energy and kinetics calculation in 2020 51
Ligand Binding, Unbinding, and Allosteric Effects: Deciphering Small-Molecule Modulation of HSP90 50
Protein–ligand binding with the coarse-grained Martini model 48
New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds 47
Sampling protein motion and solvent effect during ligand binding. 47
Molecular basis of cyclooxygenase enzymes (COXs) selective inhibition 47
Funnel metadynamics as accurate binding free-energy method 46
Totale 9.974
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Categoria #
all - tutte 31.985
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 31.985
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202116 0 0 0 0 0 0 0 0 0 0 0 16
2021/2022449 10 3 1 4 6 15 5 28 68 33 74 202
2022/2023649 91 38 25 42 71 61 11 79 94 73 40 24
2023/2024470 34 62 47 23 23 44 13 57 20 18 91 38
2024/20252.705 136 129 24 29 50 190 383 225 234 220 854 231
2025/20264.776 567 352 506 448 817 136 688 289 503 321 114 35
Totale 9.974