IRIS
LIMONGELLI, VITTORIO
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
AS - Asia 2.726
EU - Europa 2.501
NA - Nord America 2.181
SA - Sud America 368
AF - Africa 76
Continente sconosciuto - Info sul continente non disponibili 3
OC - Oceania 1
Totale 7.856
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 2.094
SG - Singapore 1.550
RU - Federazione Russa 1.054
IT - Italia 569
CN - Cina 565
BR - Brasile 298
DE - Germania 285
HK - Hong Kong 265
VN - Vietnam 175
FI - Finlandia 169
NL - Olanda 88
GB - Regno Unito 68
IE - Irlanda 68
CA - Canada 54
SE - Svezia 54
AR - Argentina 36
UA - Ucraina 36
IN - India 34
JP - Giappone 27
ZA - Sudafrica 24
CI - Costa d'Avorio 22
MX - Messico 22
BD - Bangladesh 21
FR - Francia 19
KR - Corea 19
ES - Italia 15
PL - Polonia 14
AT - Austria 13
CH - Svizzera 12
TR - Turchia 11
IQ - Iraq 10
ID - Indonesia 9
MA - Marocco 9
EC - Ecuador 8
PK - Pakistan 7
LT - Lituania 6
VE - Venezuela 6
BE - Belgio 5
CO - Colombia 5
AL - Albania 4
CL - Cile 4
CZ - Repubblica Ceca 4
IL - Israele 4
PY - Paraguay 4
KE - Kenya 3
PA - Panama 3
SA - Arabia Saudita 3
SI - Slovenia 3
TN - Tunisia 3
TW - Taiwan 3
UY - Uruguay 3
AE - Emirati Arabi Uniti 2
AO - Angola 2
AZ - Azerbaigian 2
BY - Bielorussia 2
CG - Congo 2
DZ - Algeria 2
EG - Egitto 2
EU - Europa 2
IR - Iran 2
KZ - Kazakistan 2
MQ - Martinica 2
MT - Malta 2
MY - Malesia 2
OM - Oman 2
PE - Perù 2
PS - Palestinian Territory 2
SN - Senegal 2
TH - Thailandia 2
A1 - Anonimo 1
BB - Barbados 1
BG - Bulgaria 1
BN - Brunei Darussalam 1
DK - Danimarca 1
EE - Estonia 1
ET - Etiopia 1
GE - Georgia 1
GF - Guiana Francese 1
GT - Guatemala 1
GU - Guam 1
GY - Guiana 1
HN - Honduras 1
JM - Giamaica 1
JO - Giordania 1
KH - Cambogia 1
LA - Repubblica Popolare Democratica del Laos 1
LU - Lussemburgo 1
MD - Moldavia 1
MK - Macedonia 1
ML - Mali 1
NE - Niger 1
NG - Nigeria 1
NI - Nicaragua 1
NO - Norvegia 1
PH - Filippine 1
PT - Portogallo 1
RO - Romania 1
RS - Serbia 1
SK - Slovacchia (Repubblica Slovacca) 1
TT - Trinidad e Tobago 1
Totale 7.854
Salva come PNG Salva come JPEG
Città #
Singapore 682
Hong Kong 260
Moscow 249
Chandler 230
Munich 218
Ashburn 202
Beijing 171
Naples 140
Santa Clara 112
Helsinki 98
Millbury 98
Napoli 83
Dallas 77
Hefei 76
Amsterdam 73
Los Angeles 67
Princeton 60
Nanjing 59
Ho Chi Minh City 56
Boston 45
Des Moines 43
Ottawa 40
Buffalo 39
Jacksonville 38
New York 36
Seattle 35
Hanoi 34
Redondo Beach 31
San Jose 28
Wilmington 27
Lawrence 26
São Paulo 23
Tokyo 21
The Dalles 18
Nanchang 17
Pune 15
Stockholm 15
Chicago 14
Seoul 14
Turku 14
Brooklyn 13
Atlanta 12
Dong Ket 12
Hebei 12
Houston 12
Tianjin 12
Torre Annunziata 12
Warsaw 12
Woodbridge 12
London 11
Nuremberg 11
Shenyang 11
Angri 10
Rome 10
Denver 9
Jiaxing 9
Mexico City 9
Milan 9
Poplar 9
Ankara 8
Boardman 8
Falkenstein 8
Johannesburg 8
Phoenix 8
Biên Hòa 7
Changsha 7
Dublin 7
Montreal 7
Perugia 7
Rio de Janeiro 7
Sagrado 7
Salerno 7
Belo Horizonte 6
Brasília 6
Formia 6
Frankfurt am Main 6
Jyväskylä 6
San Francisco 6
Baghdad 5
Brussels 5
Charlotte 5
Chennai 5
Curitiba 5
Da Nang 5
Dhaka 5
Hải Dương 5
Kronberg 5
Manchester 5
Salvador 5
Augusta 4
Bologna 4
Campinas 4
Cape Town 4
Düsseldorf 4
Fairfield 4
Falls Church 4
Fortaleza 4
Frattamaggiore 4
Ikari 4
Kunming 4
Totale 4.022
Salva come PNG Salva come JPEG
Nome #
Discovery of UDCA derivatives as new modulators of bile acid receptors 268
Potent dual agonists of nuclear and membrane bile acid receptors 244
Structural and conformational requisites in DNA quadruplex groove binding: Another piece to the puzzle 152
Design, synthesis and pharmacological characterization of novel potent nonsteroidal agonists of the farnesoid X receptor 143
Discovery of a Novel Class of Dual GPBAR1 Agonists-RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders 138
Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury 138
Discovery of a Potent and Orally Active Dual GPBAR1/CysLT1R Modulator for the Treatment of Metabolic Fatty Liver Disease 137
Ligand binding to telomeric G-quadruplex DNA investigated by funnel-metadynamics simulations 132
Marine and semi-sinthetic hydroxystroids as new scaffolds for pregnane X receptor modulation 130
Hyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists 128
Identification of cysteinyl-leukotriene-receptor 1 antagonists as ligands for the bile acid receptor GPBAR1 121
Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy 115
Structural and conformational requisites in DNA quadruplex groove binding: Another piece to the puzzle 115
Design and synthesis of hyodeoxycholic acid derivatives as GPBAR1 receptor modulators useful in the treatment of colon inflammation 114
Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists 112
Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1 112
Synthesis of new isoxazole derivatives as fxr agonists with improved pharmacokinetic properties 111
Discovery of Bile Acid Derivatives as Potent ACE2 Activators by Virtual Screening and Essential Dynamics 111
Modeling of Cdc25B Dual Specifity Protein Phosphatase Inhibitors: Docking of Ligands and Enzymatic Inhibition Mechanism 109
Calmodulin-Dependent Kinase II Mediates Vascular Smooth Muscle Cell Proliferation and Is Potentiated by Extracellular Signal Regulated Kinase 109
A New DNA Structural Motif: The G-Triplex 109
Computer-Aided Drug Design Unveils the Structural Requisites for Bile Acid Receptors Modulation 109
Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1 106
Modification on Ursodeoxycholic Acid (UDCA) Scaffold. Discovery of Bile Acid Derivatives As Selective Agonists of Cell-Surface G-Protein Coupled Bile Acid Receptor 1 (GP-BAR1) 102
Incisterols, highly degraded marine sterols, are a new chemotype of PXR agonists 99
Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties 98
Ensemble-docking approach on BACE-1: pharmacophore perception and guidelines for drug design 96
Indolylarylsulfones carrying a heterocyclic tail as very potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors 94
Elucidating the Binding Behavior of Highly Potent COX-2 Selective Inhibitors 93
Correction to “Discovery of a Novel Class of Dual GPBAR1 Agonists–RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders” 92
Breaking the dogma of the metal-coordinating carboxylate group in integrin ligands: introducing hydroxamic acids to the MIDAS to tune potency and selectivity 92
Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists 92
GPBAR1 activation by C6-substituted hyodeoxycholane analogues protect against colitis 92
Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors 91
Acetic Acid Aldose Reductase Inhibitors Bearing a Five-Membered Heterocyclic Core with Potent Topical Activity in a Visual Impairment Rat Model. 90
Minute-timescale free-energy calculations reveal a pseudo-active state in the adenosine A2A receptor activation mechanism 89
Discovery of amine bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 89
The glycan role in the glycopeptide immunogenicity revealed by atomistic simulations and spectroscopic experiments on the multiple sclerosis biomarker CSF114(Glc) 89
Drug Repurposing on G Protein-Coupled Receptors Using a Computational Profiling Approach 85
Stop Fitan: Antispasmodic Effect of Natural Extract of Chestnut Wood in Guinea Pig Ileum and Proximal Colon Smooth Muscle 85
Targeting bile acid receptors: discovery of a potent and selective Farnesoid X receptor agonist as a new lead in the pharmacological approach to liver diseases 85
Epoxide functionalization on cholane side chains in the identification of G-protein coupled bile acid receptor (GPBAR1) selective agonists 85
Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation 84
Insight on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges 84
The G-triplex DNA 83
Design, Synthesis, and Biological Evaluation of Novel Aminobisphosphonates Possessing an in Vivo Antitumor Activity Through a γδ -T Lymphocytes-Mediated Activation Mechanism. 82
Membrane charge dependent states of the beta -amyloid fragment A beta (16-35) with differently charged micelle aggregates 81
Design, synthesis and biologicalevaluation of carboxy analogues of arginine methyltransferase 81
Homology Modeling of NR2B Modulatory Domain of NMDA Receptor and Analysis of Ifenprodil Binding. 79
Dual binding mode of SC-558 in COX-2: A new frontier in COX inhibition 79
Dual binding mode of SC-558 in COX-2: A new frontier in COX inhibition 79
Ligand Binding to Telomeric DNA G-quadruplex through Metadynamics Calculations 77
Membrane charge dependent states of the β-amyloid fragment Aβ (16–35) with differently charged micelle aggregates 76
Investigating the mechanism of substrate uptake and release in the glutamate transporter homologue Glt(Ph) through metadynamics simulations. 74
Design, Synthesis and Biological Evaluation of Carboxy Analogues of Arginine Methyltransferase Inhibitor 1 (AMI-1) 74
Rational Drug Design of New Selective Modulators of GPBAR1 72
Bioinformatics and Biosimulations as Toolbox for Peptides and Peptidomimetics Design: Where Are We? 72
Probing the Charge Capability of the MIDAS: Phosphinic- and Phosphonic Acid Containing Compounds as New Potent allb beta 3 Integrin Antagonists 70
Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands 70
Accelerating the Calculation of Protein-Ligand Binding Free Energy and Residence Times Using Dynamically Optimized Collective Variables 68
Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism 67
Discovery of a new class of GPBAR1 modulators 66
gamma-Glutamyl 16-diaminopropane derivative of vasoactive intestinal peptide: a potent anti-oxidative agent for human epidermoid cancer cells 65
Potent Arylsulfonamide Inhibitors of Tumor Necrosis Factor-alfa Converting Enzyme Able to Reduce Activated Leukocyte Cell Adhesion Molecule Shedding in Cancer Cell Models 64
Transferring chemical and energetic knowledge between molecular systems with machine learning 63
Ethyl 8-Fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as Novel, Highly Potent, and Safe Antianxiety Agent. 63
Structural Insight into the Binding Mode of FXR and GPBAR1 Modulators 63
G-triplex structure and formation propensity 62
Disruption of TFGβ-SMAD3 pathway by the nuclear receptor SHP mediates the antifibrotic activities of BAR704, a novel highly selective FXR ligand 60
Synthesis of new oxadiazole derivatives as potent and selective FXR antagonists 59
Kinetics of protein-ligand unbinding: Predicting pathways, rates, and rate-limiting steps 55
Conformational Changes in the Epidermal Growth Factor Receptor: Role of the Transmembrane Domain Investigated by Coarse-Grained MetaDynamics Free Energy Calculations 54
Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane x receptor modulation. 53
Mechanistic insight into ligand binding to G-quadruplex DNA 52
Binding of the Anti-FIV Peptide C8 to Differently Charged Membrane Models: From First Docking to Membrane Tubulation 51
Identification of quinoline-based compounds with dual activity against CysLT1R and GPBAR1 50
Ligand binding free-energy calculations with funnel metadynamics 49
Unbinding Kinetics of a p38 MAP Kinase Type II Inhibitor from Metadynamics Simulations 48
Improving Small-Molecule Force Field Parameters in Ligand Binding Studies 47
Tailoring of integrin ligands: probing the charge capability of the metal ion-dependent adhesion site. 47
Perspectives on High-Throughput Ligand/Protein Docking With Martini MD Simulations 46
Steroidal scaffolds as FXR and GPBAR1 ligands: from chemistry to therapeutical application 45
New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds 42
DDT - Drug Discovery Tool: a fast and intuitive graphics user interface for Docking and Molecular Dynamics analysis 42
Sampling protein motion and solvent effect during ligand binding. 41
Energetics and structural characterization of the large-scale functional motion of adenylate kinase 41
Promoting transparency and reproducibility in enhanced molecular simulations 41
Ligand binding free energy and kinetics calculation in 2020 41
Funnel-metadynamics and solution NMR to estimate protein-ligand affinities 40
Molecular Modeling for Nanomaterial-Biology Interactions: Opportunities, Challenges, and Perspectives 40
Ligand Binding, Unbinding, and Allosteric Effects: Deciphering Small-Molecule Modulation of HSP90 40
The Free Energy Landscape of GABA Binding to a Pentameric Ligand-Gated Ion Channel and Its Disruption by Mutations 39
The Molecular Mechanism Underlying Ligand Binding to the Membrane-Embedded Site of a G-Protein-Coupled Receptor 39
Protein–ligand binding with the coarse-grained Martini model 39
International Scientific Collaboration Is Needed to Bridge Science to Society: USERN2020 Consensus Statement 39
Molecular basis of cyclooxygenase enzymes (COXs) selective inhibition 38
Funnel metadynamics as accurate binding free-energy method 36
To bind or not to bind: diagnosing false positives for 1:1 binding to G-Protein 35
Totale 8.048
Salva come PNG Salva come JPEG
Categoria #
all - tutte 27.233
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 27.233
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021106 0 0 0 0 0 0 21 14 35 4 16 16
2021/2022449 10 3 1 4 6 15 5 28 68 33 74 202
2022/2023649 91 38 25 42 71 61 11 79 94 73 40 24
2023/2024470 34 62 47 23 23 44 13 57 20 18 91 38
2024/20252.705 136 129 24 29 50 190 383 225 234 220 854 231
2025/20262.850 567 352 506 448 817 136 24 0 0 0 0 0
Totale 8.048