IRIS
LIMONGELLI, VITTORIO
 Distribuzione geografica
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Continente #
EU - Europa 2.076
NA - Nord America 1.465
AS - Asia 993
SA - Sud America 85
AF - Africa 39
Continente sconosciuto - Info sul continente non disponibili 3
Totale 4.661
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Nazione #
US - Stati Uniti d'America 1.418
RU - Federazione Russa 846
IT - Italia 531
SG - Singapore 489
DE - Germania 241
CN - Cina 222
HK - Hong Kong 219
FI - Finlandia 155
NL - Olanda 83
BR - Brasile 77
IE - Irlanda 66
CA - Canada 42
SE - Svezia 40
UA - Ucraina 31
GB - Regno Unito 29
CI - Costa d'Avorio 22
IN - India 17
VN - Vietnam 13
FR - Francia 10
ZA - Sudafrica 10
AT - Austria 9
CH - Svizzera 9
KR - Corea 9
JP - Giappone 7
BE - Belgio 5
MX - Messico 5
ES - Italia 4
PK - Pakistan 4
AR - Argentina 3
CZ - Repubblica Ceca 3
AL - Albania 2
EU - Europa 2
IL - Israele 2
IQ - Iraq 2
IR - Iran 2
LT - Lituania 2
MT - Malta 2
PL - Polonia 2
SN - Senegal 2
TN - Tunisia 2
TR - Turchia 2
A1 - Anonimo 1
BD - Bangladesh 1
BG - Bulgaria 1
BY - Bielorussia 1
CL - Cile 1
CO - Colombia 1
DK - Danimarca 1
EC - Ecuador 1
EG - Egitto 1
JO - Giordania 1
KE - Kenya 1
MA - Marocco 1
OM - Oman 1
PH - Filippine 1
RS - Serbia 1
SI - Slovenia 1
SK - Slovacchia (Repubblica Slovacca) 1
TH - Thailandia 1
UY - Uruguay 1
VE - Venezuela 1
Totale 4.661
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Città #
Singapore 267
Chandler 230
Moscow 220
Hong Kong 216
Munich 180
Naples 125
Santa Clara 104
Helsinki 98
Millbury 98
Napoli 83
Ashburn 71
Amsterdam 69
Princeton 60
Nanjing 58
Des Moines 43
Beijing 39
Ottawa 39
Jacksonville 37
Boston 33
Seattle 31
Wilmington 27
Lawrence 26
Nanchang 16
Pune 15
Dong Ket 12
Hebei 12
Torre Annunziata 12
Woodbridge 12
Shenyang 11
Angri 10
Tianjin 10
Rome 9
Falkenstein 8
Hefei 8
Jiaxing 8
Milan 8
Houston 7
Nuremberg 7
Perugia 7
Sagrado 7
Salerno 7
The Dalles 7
Boardman 6
Changsha 6
Dublin 6
Formia 6
Jyväskylä 6
Brussels 5
Kronberg 5
Seoul 5
Augusta 4
Bologna 4
Düsseldorf 4
Fairfield 4
Falls Church 4
Frankfurt am Main 4
Frattamaggiore 4
Ikari 4
Kunming 4
Los Angeles 4
Norwalk 4
Redwood City 4
Regensburg 4
San Mateo 4
Bari 3
Brescia 3
Caserta 3
Castellammare Di Stabia 3
Council Bluffs 3
Florence 3
Langhirano 3
Porto Alegre 3
Rio de Janeiro 3
Varedo 3
Bacoli 2
Bastia umbra 2
Brugherio 2
Caltanissetta 2
Campinas 2
Caucaia 2
Caxias do Sul 2
Cuauhtémoc 2
Curitiba 2
Córdoba 2
Dakar 2
Darmstadt 2
Edinburgh 2
Falerna 2
Franca 2
Guangzhou 2
Imsida 2
Lanzhou 2
London 2
Madrid 2
Miami 2
Monza 2
Mugnano Di Napoli 2
Mugnano di Napoli 2
Niscemi 2
Osasco 2
Totale 2.530
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Nome #
Discovery of UDCA derivatives as new modulators of bile acid receptors 216
Potent dual agonists of nuclear and membrane bile acid receptors 196
Design, synthesis and pharmacological characterization of novel potent nonsteroidal agonists of the farnesoid X receptor 90
Discovery of a Potent and Orally Active Dual GPBAR1/CysLT1R Modulator for the Treatment of Metabolic Fatty Liver Disease 87
Hyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists 86
Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury 86
Structural and conformational requisites in DNA quadruplex groove binding: Another piece to the puzzle 81
Identification of cysteinyl-leukotriene-receptor 1 antagonists as ligands for the bile acid receptor GPBAR1 80
Modeling of Cdc25B Dual Specifity Protein Phosphatase Inhibitors: Docking of Ligands and Enzymatic Inhibition Mechanism 78
Discovery of a Novel Class of Dual GPBAR1 Agonists-RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders 77
Synthesis of new isoxazole derivatives as fxr agonists with improved pharmacokinetic properties 77
Design and synthesis of hyodeoxycholic acid derivatives as GPBAR1 receptor modulators useful in the treatment of colon inflammation 76
Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists 72
Ligand binding to telomeric G-quadruplex DNA investigated by funnel-metadynamics simulations 71
Targeting bile acid receptors: discovery of a potent and selective Farnesoid X receptor agonist as a new lead in the pharmacological approach to liver diseases 70
Marine and semi-sinthetic hydroxystroids as new scaffolds for pregnane X receptor modulation 69
Computer-Aided Drug Design Unveils the Structural Requisites for Bile Acid Receptors Modulation 69
Modification on Ursodeoxycholic Acid (UDCA) Scaffold. Discovery of Bile Acid Derivatives As Selective Agonists of Cell-Surface G-Protein Coupled Bile Acid Receptor 1 (GP-BAR1) 68
Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1 68
Calmodulin-Dependent Kinase II Mediates Vascular Smooth Muscle Cell Proliferation and Is Potentiated by Extracellular Signal Regulated Kinase 67
Structural and conformational requisites in DNA quadruplex groove binding: Another piece to the puzzle 67
Discovery of Bile Acid Derivatives as Potent ACE2 Activators by Virtual Screening and Essential Dynamics 67
A New DNA Structural Motif: The G-Triplex 66
Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors 65
Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties 64
Indolylarylsulfones carrying a heterocyclic tail as very potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors 63
Homology Modeling of NR2B Modulatory Domain of NMDA Receptor and Analysis of Ifenprodil Binding. 61
GPBAR1 activation by C6-substituted hyodeoxycholane analogues protect against colitis 61
Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1 61
Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy 60
Discovery of amine bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 60
Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists 59
Ensemble-docking approach on BACE-1: pharmacophore perception and guidelines for drug design 58
Acetic Acid Aldose Reductase Inhibitors Bearing a Five-Membered Heterocyclic Core with Potent Topical Activity in a Visual Impairment Rat Model. 58
Elucidating the Binding Behavior of Highly Potent COX-2 Selective Inhibitors 54
Breaking the dogma of the metal-coordinating carboxylate group in integrin ligands: introducing hydroxamic acids to the MIDAS to tune potency and selectivity 53
Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands 53
Insight on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges 53
The glycan role in the glycopeptide immunogenicity revealed by atomistic simulations and spectroscopic experiments on the multiple sclerosis biomarker CSF114(Glc) 53
Epoxide functionalization on cholane side chains in the identification of G-protein coupled bile acid receptor (GPBAR1) selective agonists 53
Design, Synthesis, and Biological Evaluation of Novel Aminobisphosphonates Possessing an in Vivo Antitumor Activity Through a γδ -T Lymphocytes-Mediated Activation Mechanism. 50
Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation 50
Rational Drug Design of New Selective Modulators of GPBAR1 49
Accelerating the Calculation of Protein-Ligand Binding Free Energy and Residence Times Using Dynamically Optimized Collective Variables 49
Stop Fitan: Antispasmodic Effect of Natural Extract of Chestnut Wood in Guinea Pig Ileum and Proximal Colon Smooth Muscle 47
Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism 47
G-triplex structure and formation propensity 46
Discovery of a new class of GPBAR1 modulators 46
Incisterols, highly degraded marine sterols, are a new chemotype of PXR agonists 45
Bioinformatics and Biosimulations as Toolbox for Peptides and Peptidomimetics Design: Where Are We? 45
Design, synthesis and biologicalevaluation of carboxy analogues of arginine methyltransferase 44
Dual binding mode of SC-558 in COX-2: A new frontier in COX inhibition 43
Disruption of TFGβ-SMAD3 pathway by the nuclear receptor SHP mediates the antifibrotic activities of BAR704, a novel highly selective FXR ligand 43
Structural Insight into the Binding Mode of FXR and GPBAR1 Modulators 43
Dual binding mode of SC-558 in COX-2: A new frontier in COX inhibition 42
The G-triplex DNA 42
Correction to “Discovery of a Novel Class of Dual GPBAR1 Agonists–RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders” 40
Ligand Binding to Telomeric DNA G-quadruplex through Metadynamics Calculations 40
Synthesis of new oxadiazole derivatives as potent and selective FXR antagonists 40
Potent Arylsulfonamide Inhibitors of Tumor Necrosis Factor-alfa Converting Enzyme Able to Reduce Activated Leukocyte Cell Adhesion Molecule Shedding in Cancer Cell Models 38
Probing the Charge Capability of the MIDAS: Phosphinic- and Phosphonic Acid Containing Compounds as New Potent allb beta 3 Integrin Antagonists 38
Design, Synthesis and Biological Evaluation of Carboxy Analogues of Arginine Methyltransferase Inhibitor 1 (AMI-1) 37
Membrane charge dependent states of the beta -amyloid fragment A beta (16-35) with differently charged micelle aggregates 36
Kinetics of protein-ligand unbinding: Predicting pathways, rates, and rate-limiting steps 36
Conformational Changes in the Epidermal Growth Factor Receptor: Role of the Transmembrane Domain Investigated by Coarse-Grained MetaDynamics Free Energy Calculations 36
Drug Repurposing on G Protein-Coupled Receptors Using a Computational Profiling Approach 34
Ethyl 8-Fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as Novel, Highly Potent, and Safe Antianxiety Agent. 34
Tailoring of integrin ligands: probing the charge capability of the metal ion-dependent adhesion site. 34
Membrane charge dependent states of the β-amyloid fragment Aβ (16–35) with differently charged micelle aggregates 33
Investigating the mechanism of substrate uptake and release in the glutamate transporter homologue Glt(Ph) through metadynamics simulations. 33
Binding of the Anti-FIV Peptide C8 to Differently Charged Membrane Models: From First Docking to Membrane Tubulation 33
gamma-Glutamyl 16-diaminopropane derivative of vasoactive intestinal peptide: a potent anti-oxidative agent for human epidermoid cancer cells 30
Transferring chemical and energetic knowledge between molecular systems with machine learning 29
Minute-timescale free-energy calculations reveal a pseudo-active state in the adenosine A2A receptor activation mechanism 29
Mechanistic insight into ligand binding to G-quadruplex DNA 29
Steroidal scaffolds as FXR and GPBAR1 ligands: from chemistry to therapeutical application 28
Funnel-metadynamics and solution NMR to estimate protein-ligand affinities 28
Unbinding Kinetics of a p38 MAP Kinase Type II Inhibitor from Metadynamics Simulations 28
DDT - Drug Discovery Tool: a fast and intuitive graphics user interface for Docking and Molecular Dynamics analysis 28
Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane x receptor modulation. 27
Energetics and structural characterization of the large-scale functional motion of adenylate kinase 26
Molecular Modeling for Nanomaterial-Biology Interactions: Opportunities, Challenges, and Perspectives 26
Sampling protein motion and solvent effect during ligand binding. 24
Funnel metadynamics as accurate binding free-energy method 23
New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds 22
The Free Energy Landscape of GABA Binding to a Pentameric Ligand-Gated Ion Channel and Its Disruption by Mutations 22
Promoting transparency and reproducibility in enhanced molecular simulations 22
Improving Small-Molecule Force Field Parameters in Ligand Binding Studies 21
Perspectives on High-Throughput Ligand/Protein Docking With Martini MD Simulations 20
Molecular basis of cyclooxygenase enzymes (COXs) selective inhibition 20
The Molecular Mechanism Underlying Ligand Binding to the Membrane-Embedded Site of a G-Protein-Coupled Receptor 20
Ligand Binding, Unbinding, and Allosteric Effects: Deciphering Small-Molecule Modulation of HSP90 19
Protein–ligand binding with the coarse-grained Martini model 18
Ligand binding free energy and kinetics calculation in 2020 18
International Scientific Collaboration Is Needed to Bridge Science to Society: USERN2020 Consensus Statement 18
Ligand binding free-energy calculations with funnel metadynamics 17
Identification of quinoline-based compounds with dual activity against CysLT1R and GPBAR1 14
Totale 4.852
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Categoria #
all - tutte 19.124
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 19.124
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/202066 0 0 0 0 0 0 0 0 0 0 42 24
2020/2021258 20 8 28 8 37 51 21 14 35 4 16 16
2021/2022449 10 3 1 4 6 15 5 28 68 33 74 202
2022/2023649 91 38 25 42 71 61 11 79 94 73 40 24
2023/2024470 34 62 47 23 23 44 13 57 20 18 91 38
2024/20252.359 136 129 24 29 50 190 383 225 234 220 739 0
Totale 4.852