Through metadynamics calculations, the thrombin binding aptamer (TBA) has been shown to adopt a stable G-triplex structural motif, in addition to the usual G-quadruplex (see scheme). An 11-mer oligonucleotide was also shown to form a stable G-triplex, whose structural and thermodynamic properties have been characterized.

The G-triplex DNA / Limongelli, V., De Tito, S., Cerofolini, L., Fragai, M., Pagano, B., Trotta, R., Cosconati, S., Marinelli, L., Novellino, E., Bertini, I., Randazzo, A., Luchinat, C., Parrinello, M.. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 52:8(2013), pp. 2269-2273. [10.1002/anie.201206522]

The G-triplex DNA

LIMONGELLI, VITTORIO;PAGANO, BRUNO;MARINELLI, LUCIANA;NOVELLINO, ETTORE;RANDAZZO, ANTONIO;
2013

Abstract

Through metadynamics calculations, the thrombin binding aptamer (TBA) has been shown to adopt a stable G-triplex structural motif, in addition to the usual G-quadruplex (see scheme). An 11-mer oligonucleotide was also shown to form a stable G-triplex, whose structural and thermodynamic properties have been characterized.
2013
The G-triplex DNA / Limongelli, V., De Tito, S., Cerofolini, L., Fragai, M., Pagano, B., Trotta, R., Cosconati, S., Marinelli, L., Novellino, E., Bertini, I., Randazzo, A., Luchinat, C., Parrinello, M.. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 52:8(2013), pp. 2269-2273. [10.1002/anie.201206522]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/535059
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