Through metadynamics calculations, the thrombin binding aptamer (TBA) has been shown to adopt a stable G-triplex structural motif, in addition to the usual G-quadruplex (see scheme). An 11-mer oligonucleotide was also shown to form a stable G-triplex, whose structural and thermodynamic properties have been characterized.

The G-triplex DNA / Limongelli, Vittorio; De Tito, S.; Cerofolini, L.; Fragai, M.; Pagano, Bruno; Trotta, R.; Cosconati, S.; Marinelli, Luciana; Novellino, Ettore; Bertini, I.; Randazzo, Antonio; Luchinat, C.; Parrinello, M.. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 52:8(2013), pp. 2269-2273. [10.1002/anie.201206522]

The G-triplex DNA

LIMONGELLI, VITTORIO;PAGANO, BRUNO;MARINELLI, LUCIANA;NOVELLINO, ETTORE;RANDAZZO, ANTONIO;
2013

Abstract

Through metadynamics calculations, the thrombin binding aptamer (TBA) has been shown to adopt a stable G-triplex structural motif, in addition to the usual G-quadruplex (see scheme). An 11-mer oligonucleotide was also shown to form a stable G-triplex, whose structural and thermodynamic properties have been characterized.
2013
The G-triplex DNA / Limongelli, Vittorio; De Tito, S.; Cerofolini, L.; Fragai, M.; Pagano, Bruno; Trotta, R.; Cosconati, S.; Marinelli, Luciana; Novellino, Ettore; Bertini, I.; Randazzo, Antonio; Luchinat, C.; Parrinello, M.. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 52:8(2013), pp. 2269-2273. [10.1002/anie.201206522]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/535059
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