In this comunication was reported that the manipulation of the oxadiazole scaffold, modifying both substituents at C-3 and C-5, led to the synthesis of a small library of derivatives some of which characterized by a potent FXR antagonistic activity and promising pharmacokinetic properties.
Synthesis of new oxadiazole derivatives as potent and selective FXR antagonists / Festa, Carmen; Finamore, Claudia; Di Leva, Francesco Saverio; Limongelli, Vittorio; Zampella, Angela; DE MARINO, Simona. - (2019). ((Intervento presentato al convegno XXXIXConvegno della Divisione di Chimica Organica tenutosi a Torino nel 8-12 Settembre.
Synthesis of new oxadiazole derivatives as potent and selective FXR antagonists
Carmen Festa;Claudia Finamore;Francesco Saverio Di Leva;Vittorio Limongelli;Angela Zampella;Simona De Marino
2019
Abstract
In this comunication was reported that the manipulation of the oxadiazole scaffold, modifying both substituents at C-3 and C-5, led to the synthesis of a small library of derivatives some of which characterized by a potent FXR antagonistic activity and promising pharmacokinetic properties.File in questo prodotto:
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