Grape pomace, a bulky component of winery waste, is a source of healthy compounds. So far, scientific research has mainly focused on its polyphenol content, but given the impressive number of bioactivities shown by grape pomace, it is not unlikely that, besides polyphenols, additional metabolites, so far undetected, may be involved. In order to verify such hypothesis, an in-depth chemical analysis of Aglianico (Vitis vinifera) grape pomace was conducted by NMR and LC-MS/MS. In addition to a number of polyphenols, a remarkable concentration of oleanolic acid (0.45 mg/g - fresh weight) was determined in the analyzed material. Oleanolic acid is a natural triterpenoid showing many bioactivities including antitumor, anti-inflammatory, antibiotic and antiviral properties. Also, it was proven a potential antidiabetic molecule in Type1 Diabetes rats. Hence, its influence on the mitochondrial and glucose uptake activities of C2C12 myoblast was here assessed, thus supporting oleanolic acid as a promising antidiabetic metabolite.

Oleanolic acid: A promising antidiabetic metabolite detected in Aglianico grape pomace / Errichiello, Francesco; D'Amato, Maria; Gambuti, Angelita; Moio, Luigi; Pastore, Arianna; AL-Hmadi, Hekmat; Stornaiuolo, Mariano; Serino, Elena; TAGLIALATELA SCAFATI, Orazio; Forino, Martino. - In: JOURNAL OF FUNCTIONAL FOODS. - ISSN 1756-4646. - 104:(2023), pp. 105548-105556. [10.1016/j.jff.2023.105548]

Oleanolic acid: A promising antidiabetic metabolite detected in Aglianico grape pomace

Francesco Errichiello
Primo
Investigation
;
Angelita Gambuti
Data Curation
;
Luigi Moio
Formal Analysis
;
Mariano Stornaiuolo
Data Curation
;
Elena Serino
Membro del Collaboration Group
;
Orazio Taglialatela-Scafati
Penultimo
Writing – Review & Editing
;
Martino Forino
Ultimo
Conceptualization
2023

Abstract

Grape pomace, a bulky component of winery waste, is a source of healthy compounds. So far, scientific research has mainly focused on its polyphenol content, but given the impressive number of bioactivities shown by grape pomace, it is not unlikely that, besides polyphenols, additional metabolites, so far undetected, may be involved. In order to verify such hypothesis, an in-depth chemical analysis of Aglianico (Vitis vinifera) grape pomace was conducted by NMR and LC-MS/MS. In addition to a number of polyphenols, a remarkable concentration of oleanolic acid (0.45 mg/g - fresh weight) was determined in the analyzed material. Oleanolic acid is a natural triterpenoid showing many bioactivities including antitumor, anti-inflammatory, antibiotic and antiviral properties. Also, it was proven a potential antidiabetic molecule in Type1 Diabetes rats. Hence, its influence on the mitochondrial and glucose uptake activities of C2C12 myoblast was here assessed, thus supporting oleanolic acid as a promising antidiabetic metabolite.
2023
Oleanolic acid: A promising antidiabetic metabolite detected in Aglianico grape pomace / Errichiello, Francesco; D'Amato, Maria; Gambuti, Angelita; Moio, Luigi; Pastore, Arianna; AL-Hmadi, Hekmat; Stornaiuolo, Mariano; Serino, Elena; TAGLIALATELA SCAFATI, Orazio; Forino, Martino. - In: JOURNAL OF FUNCTIONAL FOODS. - ISSN 1756-4646. - 104:(2023), pp. 105548-105556. [10.1016/j.jff.2023.105548]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/919126
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