Fmoc-N,N'-Bis-Boc-7-guanyl-Tic-OH (GTIC), a conformationally constrained amino acid with basic properties, has been synthesized in four steps. This amino acid can be incorporated into peptides using std. Fmoc solid phase synthesis, and to test its potential for biol. activity applications, we prepd. an analog of H-Dmt-Tic-NH2.

A convenient synthesis of N-Fmoc-N,N'-bis-Boc-7-guanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Fmoc-N,N'-bis-Boc-7-guanyl-Tic-OH, GTIC) / Santagada, Vincenzo; Fiorino, Ferdinando; Severino, Beatrice; Salvadori, S; Lazarus L., H; Bryant S., D; Caliendo, Giuseppe. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - STAMPA. - 42:20(2001), pp. 3507-3509.

A convenient synthesis of N-Fmoc-N,N'-bis-Boc-7-guanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Fmoc-N,N'-bis-Boc-7-guanyl-Tic-OH, GTIC).

SANTAGADA, VINCENZO;FIORINO, FERDINANDO;SEVERINO, BEATRICE;CALIENDO, GIUSEPPE
2001

Abstract

Fmoc-N,N'-Bis-Boc-7-guanyl-Tic-OH (GTIC), a conformationally constrained amino acid with basic properties, has been synthesized in four steps. This amino acid can be incorporated into peptides using std. Fmoc solid phase synthesis, and to test its potential for biol. activity applications, we prepd. an analog of H-Dmt-Tic-NH2.
2001
A convenient synthesis of N-Fmoc-N,N'-bis-Boc-7-guanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Fmoc-N,N'-bis-Boc-7-guanyl-Tic-OH, GTIC) / Santagada, Vincenzo; Fiorino, Ferdinando; Severino, Beatrice; Salvadori, S; Lazarus L., H; Bryant S., D; Caliendo, Giuseppe. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - STAMPA. - 42:20(2001), pp. 3507-3509.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/342834
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