As part of a search for new potassium channel openers, the synthesis and vasorelaxant activity of new 1,4-benzoxazines I (R = H, Me, Cl, NO2, CN, D2-thiazolin-2-yl, R1 = H, Me, n = 1, 2) derived from transformation of the benzopyran skeleton of cromakalim (CRK) were described. Several new 1,4-benzoxazines were provided with significant vasorelaxant activity with an overall pharmacol. behavior similar to CRK
Synthesis and vasorelaxant activity of new 1,4-benzoxazine derivatives potassium channel openers / Caliendo, Giuseppe; Perissutti, Elisa; Santagada, Vincenzo; Fiorino, Ferdinando; Severino, Beatrice; D'EMMANUELE DI VILLA BIANCA, Roberta; Laura, Lippolis; Aldo, Pinto; Sorrentino, Raffaella. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - STAMPA. - 10:8(2002), pp. 2663-2669. [10.1016/S0968-0896(02)00091-3]
Synthesis and vasorelaxant activity of new 1,4-benzoxazine derivatives potassium channel openers.
CALIENDO, GIUSEPPE;PERISSUTTI, ELISA;SANTAGADA, VINCENZO;FIORINO, FERDINANDO;SEVERINO, BEATRICE;D'EMMANUELE DI VILLA BIANCA, ROBERTA;SORRENTINO, RAFFAELLA
2002
Abstract
As part of a search for new potassium channel openers, the synthesis and vasorelaxant activity of new 1,4-benzoxazines I (R = H, Me, Cl, NO2, CN, D2-thiazolin-2-yl, R1 = H, Me, n = 1, 2) derived from transformation of the benzopyran skeleton of cromakalim (CRK) were described. Several new 1,4-benzoxazines were provided with significant vasorelaxant activity with an overall pharmacol. behavior similar to CRKI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
