A novel and convenient microwave-assisted synthesis of an active metabolite (EXP-3174) of losartan is described. Room temperature and microwave irradiation of the reactions are compared. Synthesis by microwave irradiation gave the desired compound in higher yields and in shorter reaction times than those obtained at room temperature. © 2003 Elsevier Science Ltd. All rights reserved.
A convenient synthesis by microwave irradiation of an active metabolite (EXP-3174) of losartan / Santagada, Vincenzo; Fiorino, Ferdinando; Perissutti, Elisa; Severino, Beatrice; Terracciano, Sara; Cleber Evandro, Teixeira; Caliendo, Giuseppe. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - STAMPA. - 44:6(2003), pp. 1149-1152. [10.1016/S0040-4039(02)02835-6]
A convenient synthesis by microwave irradiation of an active metabolite (EXP-3174) of losartan.
SANTAGADA, VINCENZO;FIORINO, FERDINANDO;PERISSUTTI, ELISA;SEVERINO, BEATRICE;TERRACCIANO, SARA;CALIENDO, GIUSEPPE
2003
Abstract
A novel and convenient microwave-assisted synthesis of an active metabolite (EXP-3174) of losartan is described. Room temperature and microwave irradiation of the reactions are compared. Synthesis by microwave irradiation gave the desired compound in higher yields and in shorter reaction times than those obtained at room temperature. © 2003 Elsevier Science Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
