A novel and convenient microwave-assisted dimerization of an active peptide compound using the DKPs as scaffold is described. The key reaction giving rise to the diketopiperazine scaffold is the intermolecular coupling. No epimerization was detected in the reactions used. Conventional and microwave heating of the reactions are compared. Synthesis by microwave irradiation gave the desired compounds in higher yields and in shorter reaction times than those obtained by conventional heating. © 2003 Elsevier Science Ltd. All rights reserved.
A convenient strategy of dimerization by microwave heating and using 2,5-diketopiperazine as scaffold / Santagada, Vincenzo; Fiorino, Ferdinando; Perissutti, Elisa; Severino, Beatrice; Terracciano, Sara; Cirino, Giuseppe; Caliendo, Giuseppe. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - STAMPA. - 44:6(2003), pp. 1145-1148. [10.1016/S0040-4039(02)02836-8]
A convenient strategy of dimerization by microwave heating and using 2,5-diketopiperazine as scaffold.
SANTAGADA, VINCENZO;FIORINO, FERDINANDO;PERISSUTTI, ELISA;SEVERINO, BEATRICE;TERRACCIANO, SARA;CIRINO, GIUSEPPE;CALIENDO, GIUSEPPE
2003
Abstract
A novel and convenient microwave-assisted dimerization of an active peptide compound using the DKPs as scaffold is described. The key reaction giving rise to the diketopiperazine scaffold is the intermolecular coupling. No epimerization was detected in the reactions used. Conventional and microwave heating of the reactions are compared. Synthesis by microwave irradiation gave the desired compounds in higher yields and in shorter reaction times than those obtained by conventional heating. © 2003 Elsevier Science Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
