Distribuzione geografica
Continente #
NA - Nord America 2.486
EU - Europa 1.490
AS - Asia 876
AF - Africa 19
Continente sconosciuto - Info sul continente non disponibili 2
SA - Sud America 1
Totale 4.874
Nazione #
US - Stati Uniti d'America 2.353
IT - Italia 654
SG - Singapore 383
CN - Cina 362
FI - Finlandia 181
NL - Olanda 161
CA - Canada 132
UA - Ucraina 108
DE - Germania 107
IE - Irlanda 99
VN - Vietnam 93
SE - Svezia 49
GB - Regno Unito 44
CI - Costa d'Avorio 17
RU - Federazione Russa 17
PL - Polonia 15
IN - India 13
FR - Francia 11
BE - Belgio 9
HK - Hong Kong 8
GR - Grecia 7
AT - Austria 5
BG - Bulgaria 5
ES - Italia 5
IS - Islanda 5
IR - Iran 4
JP - Giappone 4
IL - Israele 3
CH - Svizzera 2
DK - Danimarca 2
EU - Europa 2
PK - Pakistan 2
RO - Romania 2
CL - Cile 1
EG - Egitto 1
GE - Georgia 1
KR - Corea 1
MX - Messico 1
MY - Malesia 1
NG - Nigeria 1
SI - Slovenia 1
SK - Slovacchia (Repubblica Slovacca) 1
TR - Turchia 1
Totale 4.874
Città #
Chandler 384
Singapore 272
Millbury 265
Princeton 187
Jacksonville 154
Amsterdam 128
Ashburn 127
Ottawa 117
Nanjing 103
Naples 101
Dong Ket 93
Des Moines 83
Napoli 75
Beijing 70
Boston 62
Wilmington 58
Santa Clara 40
Nanchang 36
Marano di Napoli 35
Norwalk 33
Formia 32
Shenyang 29
Lawrence 26
Hebei 23
Tianjin 22
Houston 19
Washington 17
Breda 16
Jiaxing 16
Trentola-Ducenta 16
Gdansk 15
Dublin 13
Falls Church 13
Verona 13
Changsha 11
Milan 11
Moscow 11
Guangzhou 10
Kunming 10
Ann Arbor 9
Jordanstown 9
Seattle 9
Vancouver 9
Boardman 8
Cagliari 8
Hong Kong 8
Redmond 8
Kronberg 7
Pozzuoli 7
Redwood City 7
Rome 7
Waanrode 7
Dearborn 6
Hangzhou 6
Orange 6
Bhopal 5
Indiana 5
Reykjavík 5
Salerno 5
San Mateo 5
Sofia 5
Acri 4
Augusta 4
Barano d'Ischia 4
Cisterna di Latina 4
Fairfield 4
Fisciano 4
Florence 4
Menlo Park 4
Ningbo 4
Pescara 4
Toronto 4
Turin 4
Woodbridge 4
Belfast 3
Bisaccia 3
Brugherio 3
Chengdu 3
Frankfurt am Main 3
Genoa 3
Giugliano In Campania 3
Hanover 3
Jinan 3
Linköping 3
Los Angeles 3
Miyamachi 3
Nürnberg 3
Padova 3
Palermo 3
Portici 3
Shenzhen 3
Villaricca 3
Acerra 2
Altamura 2
Bolzano 2
Brindisi 2
Calvizzano 2
Capua 2
Castellammare Di Stabia 2
Castellammare di Stabia 2
Totale 3.019
Nome #
Decreased subunit stability as a novel mechanism for potassium current impairment by a KCNQ2 C terminus mutation causing benign familial neonatal convulsions 65
Tryptamine-based derivatives as Transient Receptor Potential Melastatin type-8 (TRPM8) channel modulators 60
A novel hyperekplexia-causing mutation in the pre-trasmembrane segm 1 of the human glycine receptor alpha 1 subunit reduces membrane expression and impairs gating by agonists 60
Involvement of KCNQ2 subunits in [3H]dopamine release triggered by depolarization and pre-synaptic muscarinic receptor activation from rat striatal synaptosomes. 57
Pharmacological Targeting Of Neuronal Kv7.2/3 Channels: A Focus On Chemotypes And Receptor Sites 57
Caratterizzazione biochimica e funzionale in oociti di Xenopus Laevis e cellule CHO (Chinese Hamster Ovary Cells) di mutazioni nel gene Kcnq2 riscontrate in famiglie affette da convulsioni benigne neonatali 53
Autism and developmental disability caused by KCNQ3 gain-of-function variants 50
Decreased Subunit Stability as a Novel Mechanismfor PotassiumCurrent Impairment by a KCNQ2 C Terminus Mutation Causing Benign Familial Neonatal Convulsions 49
Non-invasive real-time in-vivo monitoring of insulin absorption from subcutaneous tissues 49
Addressing the use of PDIF-CN2 molecules in the development of n-type organic field-effect transistors for biosensing applications 46
Early treatment with quinidine in two patients with epilepsy of infancy with migrating focal seizures (EIMFS) due to gain-of-function KCNT1 mutations: functional studies, clinical responses and critical issues for personalized therapy 46
Neuronal potassium channel openers in the management of epilepsy: Role and potential of retigabine 44
Up-regulation and increased activity of KV3.4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death 43
Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of Kv7.2 and Kv7.3 potassium channel subunits 43
A novel mutation in KCNQ2 associated to BFNC, drug resistant epilepsy and mental retardation 42
A novel homozygous KCNQ3 loss-of-function variant causes non-syndromic intellectual disability and neonatal-onset pharmacodependent epilepsy 42
The voltage-sensing domain of Kv7.2 channels as a molecular target for epilepsy-causing mutations and anticonvulsants 42
Inhibition of depolarization-induced [3H]noradrenaline release from SH-SY5Y human neuroblastoma cells by some second-generation H(1) receptor antagonists through blockade of store-operated Ca(2+) channels (SOCs). 41
A novel KCNQ2 K+ channel mutation in benign neonatal convulsions and centrotemporal spikes 41
Regulation of the human ether-a-gogo related gene (HERG) K+ channels by reactive oxygen species 41
Driving with no brakes: Molecular pathophysiology of Kv7 potassium channels 41
Insights into the pathogenesis of ATP1A1-related CMT disease using patient-specific iPSCs 41
Early-onset epileptic encephalopathy caused by a reduced sensitivity of Kv7.2 potassium channels to phosphatidylinositol 4,5-bisphosphate 40
Activation of Kv7 potassium channels inhibits intracellular Ca2+ increases triggered by TRPV1-mediated pain-inducing stimuli in F11 immortalized sensory neurons 40
Differential expression of the Na+-Ca2+ exchanger transcripts and proteins in rat brain regions. 39
Gender-related issues in the pharmacology of new anti-obesity drugs 39
Synthesis and Pharmacological Characterization of Conformationally Restricted Retigabine Analogues as Novel Neuronal Kv7 Channel Activators 39
A micro-bioimpedance meter for monitoring insulin bioavailability in personalized diabetes therapy 39
Expression pattern of the ether-a-gogo-related (ERG) k+ channel-encoding genes ERG1, ERG2, and ERG3 in the adult rat central nervous system 38
Functional analysis of novel KCNQ2 and KCNQ3 gene variants found in a large pedigree with benign familial neonatal convulsions (BFNC) 38
Generation of an iPSC line (UNINAi001-A) from a girl with neonatal-onset epilepsy and non-syndromic intellectual disability carrying the homozygous KCNQ3 p.PHE534ILEfs*15 variant and of an iPSC line (UNINAi002-A) from a non-carrier, unaffected brother 38
Lysinuric protein intolerance: identification and functional analysis of mutations of the SLC7A7 gene. 37
A pharmacological study on the possible mechanisms underlying changes in TSH secretion in aged male rats 37
Retigabine and flupirtine exert neuroprotective actions in organotypic hippocampal cultures 36
M Channels Containing KCNQ2 Subunits Modulate Norepinephrine, Aspartate, and GABA Release from Hippocampal Nerve Terminals 36
Histidines 578 and 587 in the S5-S6 linker of the human Ether-a-gogo Related Gene-1 K+ channels confer sensitivity to reactive oxygen species 36
Human ether-a-gogo related gene (HERG) K+ channels as pharmacological targets: present and future implications 36
Neurobiology of coronaviruses: Potential relevance for COVID-19 36
Epileptic channelopathies caused by neuronal Kv7 (KCNQ) channel dysfunction 36
A y(+)LAT-1 mutant protein interferes with y(+)LAT-2 activity: implications for the molecular pathogenesis of lysinuric protein intolerance. 35
Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors 35
Differential expression of the Na+-Ca2+ exchanger transcripts and proteins in rat brain regions 35
Adenosine Receptors Modulate the Na+-Ca2+ Exchanger in Cerebral Nerve Endingsa 35
Critical role of large-conductance calcium- and voltage-activated potassium channels in leptin-induced neuroprotection of N-methyl-d-aspartate-exposed cortical neurons 35
A novel KCNQ3 mutation in familial epilepsy with focal seizures and intellectual disability 35
Genotype-phenotype correlations in neonatal epilepsies caused by mutations in the voltage sensor of Kv7.2 potassium channel subunits 35
Genotype-phenotype correlations in patients with de novo KCNQ2 pathogenic variants 35
Activation of pre-synaptic M-type K+ channels inhibits [3H]D-aspartate release by reducing Ca2+ entry through P/Q-type voltage-gated Ca2+ channels 34
Molecular pathophysiology and pharmacology of the voltage-sensing module of neuronal ion channels 34
Expression pattern of the ether-a-gogo-related (ERG) K+ channel-encoding genes ERG1, ERG2, and ERG3 in the adult rat central nervous system. 32
Atypical gating of M-type potassium channels conferred by mutations in uncharged residues in the S4 region of KCNQ2 causing benign familial neonatal convulsions 32
Brain distribution of the Na+/Ca2+ exchanger-encoding genes NCX1, NCX2, and NCX3 and their related proteins in the central nervous system 32
Benign familial neonatal convulsions caused by altered gating of KCNQ2/KCNQ3 potassium channels 32
Expression and function of Kv7.4 channels in rat cardiac mitochondria: Possible targets for cardioprotection 32
Coupling between the voltage-sensing and phosphatase domains of Ci-VSP 32
Kv7.3 Compound Heterozygous Variants in Early Onset Encephalopathy Reveal Additive Contribution of C-Terminal Residues to PIP2-Dependent K+ Channel Gating 32
De novo gain-of-function variants in KCNT2 as a novel cause of developmental and epileptic encephalopathy. 32
Kv7.4 channels regulate potassium permeability in neuronal mitochondria 32
Beyond Retigabine: Design, Synthesis, and Pharmacological Characterization of a Potent and Chemically Stable Neuronal Kv7 Channel Activator with Anticonvulsant Activity 31
Cardiac ion channels and antihistamines: possible mechanisms of cardiotoxicity. 31
Plasma prolactin levels in the inferior petrosal sinuses in various pituitary disorders during perihypophyseal phlebography 30
Cardiotoxic effects of antihistamines: From basics to clinics (...and back) 30
“One Health” Approach for Health Innovation and Active Aging in Campania (Italy) 30
Effects of manidipine and nitrendipine enantiomers on the plateau phase of K+-induced intracellular Ca2+ increase in GH3 cells. 29
Molecular basis for the lack of HERG K+ channel block-related cardiotoxicity by the H1 receptor blocker cetirizine compared with other second-generation antihistamines 29
Blockade of herg K+ channels by second-generation H1 receptor-antagonists may regulate [Ca2+]i oscillations in GH3 cells 29
Manidipine and Nitrendipine R and S enantiomers block voltage-gated Ca2+ channel (VGCC) with different kinetic in GH3 cell 28
Differential Vulnerability of Cortical and Cerebellar Neurons in Primary Culture to Oxygen Glucose Deprivation followed by Reoxygenation. 27
Modulation of ion channels by reactive oxygen and nitrogen species: a pathophysiological role in brain aging? 27
Correlating the Clinical and Genetic Features of Benign Familial Neonatal Seizures (BFNS) with the Functional Consequences of Underlying Mutations 27
K(V)7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fund 27
Identification of a Potent Tryptophan-based TRPM8 Antagonist With in vivo Analgesic Activity 27
IgG Autoantibodies Against IgE from Atopic Dermatitis Can Induce the Release of Cytokines and Proinflammatory Mediators from Basophils and Mast Cells 27
Pharmacological blockade of ERG K+ channels and Ca2+ influx through store-operated channels exerts opposite effects on intracellular Ca2+ oscillations in pituitary GH3 cells 26
Human neoplastic mesothelial cells express voltage-gated sodium channels involved in cell motility 26
Effects of pharmacological manipulation of calcium channels on endogenous dopamine release from tuberoinfundibular neurons 26
Expression, Localization, and Pharmacological Role of Kv7 Potassium Channels in Skeletal Muscle Proliferation, Differentiation, and Survival after Myotoxic Insults 26
Specification of skeletal muscle differentiation by repressor element-1 silencing transcription factor (REST)-regulated Kv7.4 potassium channels 26
Gating currents from Kv7 channels carrying neuronal hyperexcitability mutations in the voltage-sensing domain 26
Modulation of ion channels by reactive oxygen and nitrogen species: a pathophysiological role in brain aging? 25
Nuclear Factor-kappaB activation by reactive oxygen species mediates voltage-gated K+ current enhancement by neurotoxic beta-amyloid peptides in nerve growth factor-differentiated PC-12 cells and hippocampal neurones 25
Epileptic encephalopathy in a patientwith a novel variant in the Kv7.2 S2 transmembrane segment: Clinical, genetic, and functional features 25
Towards the realization of label-free biosensors through impedance spectroscopy integrated with IDES technology. 25
Distinct epilepsy phenotypes and response to drugs in KCNA1 gain- and loss-of function variants 25
KCNQ2 R144 variants cause neurodevelopmental disability with language impairment and autistic features without neonatal seizures through a gain-of-function mechanism 24
A novel KCNQ2 K+ channel mutation in benign neonatal convulsions and centrotemporal spikes. 24
Telethon 24
Calcium channel as molecular target of drug action. 24
Molecular mechanisms involved in beta-amyloid-induced enhancement of voltage-gated K+ channels during neuronal apoptosis 23
A new Italian FHM2 family: Clinical aspects and functional analysis of the disease-associated mutation 23
Infantile spasms and encephalopathy without preceding neonatal seizures caused by KCNQ2 R198Q, a gain-of-function variant 23
Neutralization of a unique, negatively-charged residue in the voltage sensor of KV7.2 subunits in a sporadic case of benign familial neonatal seizures 23
Pure uptake blockers of dopamine can reduce prolactin secretion: studies with diclofensine 22
Protein-tyrosine kinases activate while protein-tyrosine phosphatases inhibit L-type calcium channel activity in pituitary GH3 cells. 22
Gating consequences of charge neutralization of arginine residues in the S4 segment of K(v)7.2, an epilepsy-linked K+ channel subunit 22
Domperidone antagonizes bromoergocriptine--induced nausea and vomiting without affecting its inhibition of prolactin secretion in puerperal women. 22
Gating currents from neuronal KV7.4 Channels: General features and correlation with the ionic conductance 22
Amyloid-beta Protein Precursor Regulates Phosphorylation and Cellular Compartmentalization of Microtubule Associated Protein Tau 22
Totale 3.433
Categoria #
all - tutte 23.944
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 23.944

Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020595 210 28 32 6 41 9 25 2 2 44 101 95
2020/2021498 19 32 31 31 42 78 38 33 39 16 44 95
2021/20221.029 14 7 5 14 15 33 10 38 120 62 213 498
2022/20231.166 229 118 21 148 135 98 8 73 150 132 44 10
2023/2024826 40 93 97 52 60 79 22 71 19 17 189 87
2024/2025293 293 0 0 0 0 0 0 0 0 0 0 0
Totale 5.187