IRIS
PERSICO, MARCO
 Distribuzione geografica
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Continente #
AS - Asia 4.292
NA - Nord America 4.141
EU - Europa 3.230
SA - Sud America 458
Continente sconosciuto - Info sul continente non disponibili 266
AF - Africa 95
OC - Oceania 3
Totale 12.485
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Nazione #
US - Stati Uniti d'America 3.964
SG - Singapore 1.980
RU - Federazione Russa 1.236
IT - Italia 1.049
CN - Cina 842
VN - Vietnam 702
BR - Brasile 351
HK - Hong Kong 329
FR - Francia 148
DE - Germania 137
FI - Finlandia 126
IE - Irlanda 113
CA - Canada 110
NL - Olanda 99
JP - Giappone 80
SE - Svezia 77
IN - India 73
GB - Regno Unito 72
UA - Ucraina 69
BD - Bangladesh 63
AR - Argentina 40
MX - Messico 32
CI - Costa d'Avorio 28
IQ - Iraq 28
KR - Corea 25
ZA - Sudafrica 23
ID - Indonesia 21
PH - Filippine 19
PL - Polonia 19
ES - Italia 18
EC - Ecuador 17
AT - Austria 16
PK - Pakistan 16
TH - Thailandia 16
TR - Turchia 14
CL - Cile 10
CO - Colombia 10
JM - Giamaica 10
PY - Paraguay 10
KE - Kenya 9
SA - Arabia Saudita 9
TW - Taiwan 9
VE - Venezuela 9
JO - Giordania 8
NP - Nepal 8
BE - Belgio 7
TN - Tunisia 7
UZ - Uzbekistan 7
CY - Cipro 6
IL - Israele 6
MA - Marocco 6
HN - Honduras 5
LT - Lituania 5
MY - Malesia 5
BB - Barbados 4
BO - Bolivia 4
CH - Svizzera 4
CR - Costa Rica 4
ET - Etiopia 4
GE - Georgia 4
GT - Guatemala 4
PE - Perù 4
RO - Romania 4
AZ - Azerbaigian 3
EG - Egitto 3
IR - Iran 3
MD - Moldavia 3
NG - Nigeria 3
PT - Portogallo 3
SK - Slovacchia (Repubblica Slovacca) 3
AU - Australia 2
BA - Bosnia-Erzegovina 2
BG - Bulgaria 2
BY - Bielorussia 2
CZ - Repubblica Ceca 2
DO - Repubblica Dominicana 2
EE - Estonia 2
GR - Grecia 2
LB - Libano 2
MK - Macedonia 2
OM - Oman 2
QA - Qatar 2
SN - Senegal 2
SY - Repubblica araba siriana 2
TT - Trinidad e Tobago 2
YE - Yemen 2
AE - Emirati Arabi Uniti 1
AL - Albania 1
AO - Angola 1
BH - Bahrain 1
BW - Botswana 1
BZ - Belize 1
CD - Congo 1
CM - Camerun 1
CV - Capo Verde 1
DK - Danimarca 1
DM - Dominica 1
DZ - Algeria 1
EU - Europa 1
GA - Gabon 1
Totale 12.201
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Città #
Singapore 938
San Jose 655
Chandler 412
Ashburn 341
Hong Kong 317
Moscow 309
Beijing 228
Santa Clara 205
Napoli 194
Ho Chi Minh City 183
Hanoi 147
Naples 141
The Dalles 129
Millbury 106
Hefei 92
Lauterbourg 92
Council Bluffs 91
Los Angeles 86
Princeton 85
Rome 84
Amsterdam 79
Nanjing 79
Tokyo 68
Dallas 67
Boston 61
Jacksonville 60
Ottawa 51
Buffalo 49
Dong Ket 47
Redondo Beach 45
New York 41
São Paulo 41
Des Moines 39
Dearborn 33
Da Nang 30
Helsinki 29
Orem 29
Frankfurt am Main 28
Ann Arbor 27
Nanchang 25
Haiphong 24
Munich 23
Wilmington 23
Chicago 22
Milan 22
San Francisco 21
Shenyang 21
Falkenstein 20
Lawrence 20
Tianjin 20
Hebei 19
Seattle 19
Washington 19
Boardman 18
Denver 16
Houston 16
Montreal 16
Norwalk 15
Nuremberg 15
Phoenix 15
Vietri Sul Mare 15
Warsaw 15
Piombino 14
Atlanta 13
Brooklyn 13
Changsha 13
Mexico City 13
Kronberg 12
Pozzuoli 12
Seoul 12
Falls Church 11
Guangzhou 11
London 11
Thái Nguyên 11
Chennai 10
Coimbatore 10
Jiaxing 10
Menlo Park 10
Metaponto 10
Ninh Bình 10
Baghdad 9
Belo Horizonte 9
Toronto 9
Turku 9
Vancouver 9
Woodbridge 9
Dhaka 8
Dublin 8
Kunming 8
Mugnano di Napoli 8
Pune 8
Redwood City 8
Charlotte 7
Guayaquil 7
Hải Dương 7
Kochi 7
Nairobi 7
Poplar 7
Salerno 7
Shanghai 7
Totale 6.541
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Nome #
Investigating the Role of T7 and T12 Residues on the Biological Properties of Thrombin-Binding Aptamer 255
Synthesis, structural behaviors and biological properties of thrombin binding aptamers singly modified with chiral m-nitro-benzene glycidoyl moiety 204
Exploring the photodynamic properties of two antiproliferative benzodiazopyrrole derivatives 187
HYBRIDS BETWEEN H2S-DONORS AND BETAMETHASONE 17-VALERATE OR TRIAMCINOLONE ACETONIDE: IN VITRO EFFECT IN ASTHMA TREATMENT 172
New antimalarial 3-methoxy-1,2-dioxanes: optimization of cellular pharmacokinetic and pharmacodynamic properties by incorporation of amino and N-heterocyclic moieties at C4. 159
Cationic porphyrins are tunable gatekeepers of the 20S proteasome 158
Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue 156
Synthesis, biological evaluation, and electrochemical studies of antiplasmodial thiazinoquinones inspired by marine natural products 153
Specific Targeting Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. Design, Synthesis, and Biological Evaluation of Novel, Potent, and Broad Spectrum NNRTIs with Antiviral Activity 151
Investigating the role of T7 and T12 residues on biological properties of Thrombin Binding Aptamer: enhancement of anticoagulant activity by a single nucleobase modification 151
Exploring the antimalarial potential of the methoxy-​thiazinoquinone scaffold: Identification of a new lead candidate 151
Benzodiazepine Scaffold as Drug-like Molecular Simplification of FR235222: A Chemical Tool for Exploring HDAC Inhibition 149
A multidisciplinary approach for the investigation of the antimalarial activity of natural endoperoxides 149
ANTIMALARIAL POTENTIAL OF SYNTHETIC QUINONE DERIVATIVES DESIGNED ON THE MODEL OF THE APLIDINONES, NATURAL MARINE THIAZINOQUINONES 148
Investigating the antiparasitic potential of the marine sesquiterpene avarone, its reduced form avarol, and the novel semisynthetic thiazinoquinone analogue thiazoavarone 147
Hybrids between H2S-donors and betamethasone 17-valerate or triamcinolone acetonide inhibit mast cell degranulation and promote hyperpolarization of bronchial smooth muscle cells 147
Investigating the Neuroprotective Effects of Turmeric Extract: Structural Interactions of β-Amyloid Peptide with Single Curcuminoids 143
Antiplasmodial activity of p-substituted benzyl thiazinoquinone derivatives and their potential against parasitic infections 141
3D-Structure Activity Relationships of New Simple Antimalarial Endoperoxides 139
Insight into the mechanism of action of marine cytotoxic thiazinoquinones 138
Identification of new multi-stage thiazinoquinone compounds with activity against Schistosoma mansoni 138
Use of Integrated Computational Approaches in the Search for New Therapeutic Agents 137
Cis-trans photodynamics of benzodiazopyrrole derivatives in view of biomedical applications 136
Structural and biological studies on new TBA analogues: the role of TBA-quadruplex molecularity in the TBA-thrombin complex 136
Taxol: a Great Peptido Mimetic Produced byNature 134
A multidisciplinary approach for the investigation of the antimalarial activity of natural endoperoxides 134
The thiazinoquinone scaffold as chemical starting point for the design and synthesis of antiparasitic drugs 133
Fighting Multiparasitism, a Neglected Reality in Marginalised Community: New Tools from the Sea 133
Porphyrins, sometimes bolt and sometimes bump key of proteasome 131
Tetrasubstituted Pyrrole Derivative Mimetics of Protein–Protein Interaction Hot-Spot Residues: A Promising Class of Anticancer Agents Targeting Melanoma Cells 126
Insight into the mechanism of the antimalarial action of plakortins, simple 1,2-dioxane antimalarials 124
Marine inspired antiplasmodial thiazinoquinones: synthesis, computational studies and electrochemical assays 124
From Protein Communication to Drug Discovery 120
New Anticancer Agents Mimicking Protein Recognition Motifs. 119
Modulation of the 20S Proteasome Activity by Porphyrin Derivatives Is Steered through Their Charge Distribution 118
Exploiting extra-interaction sites in the mid-gorge and peripheral site of cholinesterase: rational design of novel, selective, and highly potent inhibitors 118
3D-Structure Activity Relationships of New Simple Antimalarial Endoperoxides 117
Derivati 1,2-diossanici di origine marina ad attività antimalarica 117
GTP is an allosteric modulator of the interaction between the guanylate-binding protein 1 and the prosurvival kinase PIM1 117
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling 116
A multidisciplinary approach to study the carboxyl-terminal portion of the excitatory amino acid transporter EAAT2:implications for the design of new neuroprotective agents. 116
The interaction of heme with plakortin and a synthetic endoperoxide analogue: new insights into the heme-activated antimalarial mechanism 116
Antimalarial Endoperoxides Inspired by Plakortin 115
Synthesis, Anticancer Activity and Computational SAR Analysis of Acylsulfonylpiperazines Derivatives 115
Antimalarial 1,2-dioxanes inspired by marine natural products. 113
Elucidation of the action mechanism of new antimalarial endoperoxides: a dft investigation to support drug design. 3D-Structure Activity Relationships of new simple antimalarial endoperoxides. 113
Cooperative binding of the cationic porphyrin tris-t4 enhances catalytic activity of 20s proteasome unveiling a complex distribution of functional states 113
Investigating the Antimalarial Potential of Plakortin, a Marine Endoperoxide 112
Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships. 110
Computer-Aided Drug Discovery from Marine Compounds: Identification of the Three-Dimensional Structural Features Responsible for Antimalarial Activity 110
Development of novel and potent atypical antipsychotic agents: from rational design to drug candidates 109
Exploiting protein fluctuation at human cholinesterase active-sites. New Perspectives 109
Electrostatic Map of Proteasome α-Rings Encodes the Design of Allosteric Porphyrin-Based Inhibitors Able to Affect 20S Conformation by Cooperative Binding 109
A multidisciplinary approach disclosing unexplored Aflatoxin B1 roles in severe impairment of vitamin D mechanisms of action 108
Eco-friendly Synthesis and Molecular Modelling of 2-Phenylimidazo[1,2-b]pyridazine Derivatives: In Vitro and In Vivo Studies for Lead Optimization 108
Antimalarial endoperoxides inspired by plakortin 107
Investigation of a novel pharmacophore for the development ofinnovative antimalarial agents. 107
Antimalarial Potential Of Synthetic Thiazinoquinones 107
Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cells. 106
Cancer Chemoprevention and Dietary Polyphenols 104
Derivati 1,2-diossanici di origine marina ad attività antimalarica 103
A DFT Study on the Antimalarial Endoperoxides Mechanism of Action. Implications for the Design of New Antimalarial Agents 103
Development of Molecular Probes for the Identification of Extra Interaction Sites in the Mid-Gorge and Peripheral Sites of Butyrylcholinesterase (BuChE). Rational Design of Novel, Selective, and Highly Potent BuChE Inhibitors 100
New Insights into the Structure-Activity Relationship and Neuroprotective Profile of Benzodiazepinone Derivatives of Neurounina-1 as Modulators of the Na+/Ca2+Exchanger Isoforms 97
DESIGN, SYNTHESIS, AND IN VITRO BIOLOGICAL EVALUATIONOF 7-CHLORO-4-QUINOLYLHYDRAZONES AS PROMISING ANTIMALARIALAGENTS 96
Discovery of a spirocyclic 3-bromo-4,5-dihydroisoxazole covalent inhibitor of hGAPDH with antiproliferative activity against pancreatic cancer cells 95
Clotrimazole Scaffold as an Innovative Pharmacophore Towards Potent Antimalarial Agents: Design, Synthesis, and Biological and Structure–Activity Relationship Studies 94
Progettazione di nuovi agenti anti infettivi per il trattamento della malaria e delle infezioni causate dal virus dell' hiv e dell' hcv 92
DESIGN AND SYNTHESIS OF NOVEL ANTIMALARIAL AGENTSBASED ON A POLYAROMATIC SCAFFOLD 91
A DFT Study on the Antimalarial Endoperoxides Mechanism of Action. Implications for the Design of New Antimalarial Agents 91
Preparation of 4-aminoquinoline derivatives as antimalaria drugs. 90
Investigating the Antimalarial Potential of Plakortin, a Marine Endoperoxide 90
Tetra-anionic porphyrin mimics protein-protein interactions between regulatory particles and the catalytic core, allosterically activating human 20S proteasome 89
Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663 89
Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation 88
Marine endoperoxides as antiprotozoan lead compounds 88
The paradox of Bcl-2: How does paclitaxel convert Bcl-2 function from antiapoptotic to proapoptotic? 88
Investigation of the Bcl-2 multimerisation process: Structural and functional implications. 87
Design, Synthesis and Structure-Activity Relationship Studies of 4-Quinolinyl- and 9-Acrydinylhydrazones as Potent Antimalarial Agents 85
Design and synthesis of simple antimalarial endoperoxides. Toward the development of an innovative 3D pharmacophoric model 83
Structure-activity relationships (SARs) of manadoperoxides A-D, endoperoxyketal polyketides from an Indonesian sponge Plakortis sp., confirm a conformation dependent antimalarial mechanism of action of plakortins. 82
Covalent Inhibitors of Plasmodium falciparum Glyceraldehyde 3-Phosphate Dehydrogenase with Antimalarial Activity in Vitro 82
Silybins are stereospecific regulators of the 20S proteasome 82
Marine endoperoxides as antiprotozoan lead compounds 81
Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D3 and Serotonin 5-HT1A and 5-HT2A Receptors. 80
Marine endoperoxides as antiprotozoan lead compounds 80
New pharmacophores with potent antimalarial activity. 80
Endoperoxide polyketides from a Chinese Plakortis simplex: further evidence of the impact of stereochemistry on antimalarial activity of simple 1,2-dioxanes. 80
Endoperoxide Derivatives from Marine Organisms: 1,2-Dioxanes of the Plakortin Family as Novel Antimalarial Agents. 78
Paclitaxel Directly Binds to Bcl-2 and Functionally Mimics Activity of Nur77. 78
Innovative approaches for the treatment of malaria: design and synthesis of potent antimalarials based on clotrimazole scaffold. 78
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors. 77
Design and synthesis of simple antimalarial endoperoxides. Toward the development of an innovative 3D pharmacophoric model 77
Toward the development of an innovative 3D pharmacophoric model 77
Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of potent and selective competitive nucleotide-mimicking inhibitors. 77
Oxidative stress-mediated antimalarial activity of plakortin, a natural endoperoxide from the tropical sponge Plakortissimplex 76
null 76
New Promising Curcumin Mimics as Neurodegenerative Hallmarks Rescuers 74
Editorial (Thematic Issue: Protein Interfaces as Targets in Drug Discovery) 74
Manadoperoxides A-D from the Indonesian Sponge Plakortis cfr. simplex. Further insights on the structure-activity relationships of simple 1,2-dioxane antimalarials 73
Totale 11.334
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Categoria #
all - tutte 40.641
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 40.641
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022754 0 4 3 36 10 26 4 81 107 75 153 255
2022/2023927 113 71 17 90 110 121 18 109 141 72 59 6
2023/2024580 25 70 64 61 43 67 21 54 9 22 94 50
2024/20252.868 147 196 12 28 81 201 336 185 197 240 1.004 241
2025/20265.553 594 400 565 458 1.086 212 683 298 599 372 170 116
2026/2027286 110 176 0 0 0 0 0 0 0 0 0 0
Totale 12.485