Herein, we report optically pure modified acyclic nucleosides as ideal probes for aptamer modification. These new monomers offer unique advantages in exploring the role played in thrombin inhibition by a single residue modification at key positions of the TBA structure.
Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue / Scuotto, Maria; Persico, Marco; Bucci, Mariarosaria; Vellecco, Valentina; Borbone, Nicola; Morelli, Elena; Oliviero, Giorgia; Novellino, Ettore; Piccialli, Gennaro; Cirino, Giuseppe; Varra, Michela; Fattorusso, Caterina; Mayol, Luciano. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - 12:28(2014), pp. 5235-5242. [10.1039/c4ob00149d]
Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue
SCUOTTO, MARIA;PERSICO, MARCO;BUCCI, MARIAROSARIA;VELLECCO, VALENTINA;BORBONE, NICOLA;MORELLI, ELENA;OLIVIERO, GIORGIA;NOVELLINO, ETTORE;PICCIALLI, GENNARO;CIRINO, GIUSEPPE;VARRA, MICHELA
;FATTORUSSO, CATERINA
;MAYOL, LUCIANO
2014
Abstract
Herein, we report optically pure modified acyclic nucleosides as ideal probes for aptamer modification. These new monomers offer unique advantages in exploring the role played in thrombin inhibition by a single residue modification at key positions of the TBA structure.| File | Dimensione | Formato | |
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