IRIS
FRALDI, ALESSANDRO
 Distribuzione geografica
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Continente #
NA - Nord America 692
EU - Europa 477
AS - Asia 100
AF - Africa 8
SA - Sud America 1
Totale 1.278
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Nazione #
US - Stati Uniti d'America 677
IT - Italia 258
CN - Cina 79
NL - Olanda 70
UA - Ucraina 32
FI - Finlandia 30
IE - Irlanda 30
DE - Germania 21
CA - Canada 13
FR - Francia 12
SE - Svezia 12
VN - Vietnam 12
CI - Costa d'Avorio 8
GB - Regno Unito 6
BE - Belgio 2
BZ - Belize 2
CH - Svizzera 2
JP - Giappone 2
KR - Corea 2
PL - Polonia 2
SG - Singapore 2
CL - Cile 1
IN - India 1
IQ - Iraq 1
SA - Arabia Saudita 1
Totale 1.278
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Città #
Chandler 160
Naples 85
Amsterdam 68
Napoli 47
Jacksonville 36
Boston 35
Princeton 31
Millbury 28
Ashburn 25
Beijing 24
Nanjing 22
Des Moines 21
Dearborn 20
Lawrence 14
Dong Ket 12
Ottawa 12
Milan 10
Fairfield 8
San Jose 8
Wilmington 8
Shenyang 7
Nanchang 6
Hebei 5
Houston 5
Norwalk 5
Padova 5
Redwood City 5
New York 4
Ann Arbor 3
Aprilia 3
Jiaxing 3
Turin 3
Woodbridge 3
Atlanta 2
Avellino 2
Aversa 2
Belize City 2
Boardman 2
Canegrate 2
Changsha 2
Dublin 2
Duncan 2
Epalinges 2
Falls Church 2
Forio 2
Frankfurt am Main 2
Kronberg 2
Kunming 2
Los Angeles 2
Nashville 2
Nocera Inferiore 2
Philadelphia 2
Rocca San Felice 2
Salerno 2
Santa Maria A Vico 2
Seattle 2
Tianjin 2
Venezia 2
Waanrode 2
Altamura 1
Bacoli 1
Baghdad 1
Baronissi 1
Berlin 1
Bethesda 1
Brescia 1
Casaluce 1
Caserta 1
Cava 1
Centrale 1
Chicago 1
Cologne 1
Dugenta 1
Formia 1
Fuzhou 1
Guidonia Montecelio 1
Göttingen 1
Icheon-si 1
Ischia 1
Jinhua 1
Lanzhou 1
Lappeenranta 1
Livingston 1
London 1
Modena 1
Montréal 1
Mugnano Di Napoli 1
Ningbo 1
Noisy-le-sec 1
Osimo 1
Palermo 1
Pasadena 1
Redmond 1
Riyadh 1
Rome 1
Saint Louis 1
Santa Clara 1
Santiago 1
Sarno 1
Shanghai 1
Totale 824
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Nome #
Retinal Degeneration in MPS-IIIA Mouse Model 151
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) 107
Multistep, sequential control of the trafficking and function of the multiple sulfatase deficiency gene product, SUMF1 by PDI, ERGIC-53 and ERp44. 59
Transcription-dependent association of multiple P-TEFb units to a hexim multimer. 49
Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases 49
Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders 44
Enhanced Version of Human Sulfamidase Significantly Ameliorates CNS Pathology When Delivered to the MPS-IIIA Mice by AAV-Mediated Intra-CSF Injection 44
Functional inactivation of Cdk9 through oligomerization chain reaction 41
Functional inactivation of Cdk9 through oligomerization chain reaction. 38
Glycosaminoglycan levels and structure in a mucopolysaccharidosis IIIA mice and the effect of a highly secreted sulfamidase engineered to cross the blood-brain barrier 38
A Block of Autophagy in Lysosomal Storage Disorders 36
Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2 36
Lysosomal storage diseases as disorders of autophagy 35
Access to cerebrospinal fluid in piglets via the cisterna magna: Optimization and description of the technique 35
Targeting neuronal proteostasis to treat the CNS in lysosomal storage diseases 33
The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease 31
Phosphorylation-regulated degradation of the tumor-suppressor form of PED by chaperone-mediated autophagy in lung cancer cells 30
Efficacy of a combined intracerebral and systemic gene delivery approach for the treatment of a severe lysosomal storage disorder. 30
A comprehensive map of CNS transduction by eight recombinant adeno-associated virus serotypes upon cerebrospinal fluid administration in pigs 30
A highly secreted sulphamidase engineered to cross the blood-brain barrier corrects brain lesions of mice with mucopolysaccharidoses type IIIA. 29
Cell trafficking of SUMF1 described by functional proteomics experiments 28
Distinct regions of cyclinT1 are required for binding to CDK9 and for recruitment to the HIV-1 Tat/TAR complex. 28
Brain Targeting in MPS-IIIA 28
Enhancing the Therapeutic Potential of Sulfamidase for the Treatment of Mucopolysaccharidosis IIIA 28
Intracerebral Administration of Adeno-Associated Viral Vector Serotype rh.10 Carrying Human SGSH and SUMF1 cDNAs in Children with Mucopolysaccharidosis Type IIIA Disease: Results of a Phase I/II Trial. 27
MAQ1 and 7K RNA interact with CDK9/Cyclin T complexes in a transcription-dependent manner 26
Inhibition of Tat activity by the HEXIM1 protein. 26
Sulfatase activities are regulated by the interaction of the sulfatase-modifying factor 1 with SUMF2 25
Gene therapy for mucopolysaccharidoses: in vivo and ex vivo approaches 25
Signals from the lysosome: a control centre for cellular clearance and energy metabolism. 24
Inhibition of Lipofuscin Aggregation by Molecular Tweezers. 24
Functional correction of CNS lesions in an MPS-IIIA mouse model by intracerebral AAV-mediated delivery of sulfamidase and SUMF1 genes. 23
Autophagy contributes to inflammation in patients with TNFR-associated periodic syndrome (TRAPS). 23
Transdermal spinal catheter placement in piglets: Description and validation of the technique. 22
Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders 22
Protein aggregation and autophagy dysfunction: new lessons from mucopolysaccharidoses 22
Brain Disorders Due to Lysomal Dysfunction 21
Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer. 20
Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor 19
Therapy of sulfatase deficiencies 18
Impaired parkin-mediated mitochondrial targeting to autophagosomes differentially contributes to tissue pathology in lysosomal storage diseases 17
Transcriptional activation of lysosomal exocytosis promotes cellular clearance. 15
SUMF1 enhances sulfatase activities in vivo in five sulfatase deficiencies. 11
Therapeutic strategies to treat CNS pathology in Mucopolysaccharidoses 11
Protein Aggregation and Dysfunction of Autophagy-Lysosomal Pathway: A Vicious Cycle in Lysosomal Storage Diseases 5
In vivo Gene Therapy to the Liver and Nervous System: Promises and Challenges 4
Totale 1.487
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Categoria #
all - tutte 5.848
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 5.848
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/201913 0 0 0 0 0 0 0 0 0 0 12 1
2019/2020345 71 6 6 0 33 4 21 7 142 11 21 23
2020/2021112 1 12 18 6 16 9 12 1 15 1 6 15
2021/2022265 6 0 2 9 16 6 3 8 35 15 55 110
2022/2023377 54 53 7 18 45 34 5 30 45 62 20 4
2023/2024221 23 31 76 12 12 20 11 14 9 12 1 0
Totale 1.487