IRIS
FRALDI, ALESSANDRO
 Distribuzione geografica
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Continente #
AS - Asia 2.344
NA - Nord America 2.097
EU - Europa 2.005
SA - Sud America 327
Continente sconosciuto - Info sul continente non disponibili 238
AF - Africa 63
OC - Oceania 7
Totale 7.081
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Nazione #
US - Stati Uniti d'America 2.006
SG - Singapore 1.004
IT - Italia 764
RU - Federazione Russa 664
VN - Vietnam 465
CN - Cina 410
BR - Brasile 259
HK - Hong Kong 176
NL - Olanda 118
DE - Germania 98
FR - Francia 93
FI - Finlandia 54
GB - Regno Unito 54
BD - Bangladesh 53
CA - Canada 48
JP - Giappone 45
IN - India 39
UA - Ucraina 36
KR - Corea 35
IE - Irlanda 32
AR - Argentina 24
MX - Messico 22
ZA - Sudafrica 20
ID - Indonesia 19
PH - Filippine 18
TR - Turchia 18
SE - Svezia 17
CH - Svizzera 14
PL - Polonia 14
AT - Austria 13
EC - Ecuador 12
IQ - Iraq 12
CI - Costa d'Avorio 9
PK - Pakistan 8
AU - Australia 7
MA - Marocco 7
PY - Paraguay 7
TH - Thailandia 7
UY - Uruguay 7
DZ - Algeria 6
ES - Italia 6
SA - Arabia Saudita 6
BE - Belgio 5
CO - Colombia 5
KE - Kenya 5
AL - Albania 4
BO - Bolivia 4
LB - Libano 4
LT - Lituania 4
NG - Nigeria 4
PE - Perù 4
TW - Taiwan 4
AZ - Azerbaigian 3
CL - Cile 3
CR - Costa Rica 3
IR - Iran 3
MY - Malesia 3
NI - Nicaragua 3
NP - Nepal 3
RO - Romania 3
AE - Emirati Arabi Uniti 2
BF - Burkina Faso 2
BG - Bulgaria 2
BH - Bahrain 2
BY - Bielorussia 2
BZ - Belize 2
EG - Egitto 2
ET - Etiopia 2
HR - Croazia 2
JM - Giamaica 2
PA - Panama 2
SN - Senegal 2
TN - Tunisia 2
TT - Trinidad e Tobago 2
VE - Venezuela 2
CU - Cuba 1
CY - Cipro 1
CZ - Repubblica Ceca 1
DK - Danimarca 1
GA - Gabon 1
GD - Grenada 1
GE - Georgia 1
GR - Grecia 1
GT - Guatemala 1
HN - Honduras 1
IL - Israele 1
KZ - Kazakistan 1
LI - Liechtenstein 1
MD - Moldavia 1
PR - Porto Rico 1
PT - Portogallo 1
SC - Seychelles 1
SY - Repubblica araba siriana 1
VC - Saint Vincent e Grenadine 1
VG - Isole Vergini Britanniche 1
Totale 6.843
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Città #
Singapore 468
San Jose 340
Naples 264
Chandler 167
Hong Kong 162
Ashburn 160
Moscow 138
Ho Chi Minh City 137
Beijing 121
Santa Clara 107
Hanoi 90
Amsterdam 81
Hefei 62
Los Angeles 53
Lauterbourg 49
Napoli 49
Boston 45
Council Bluffs 45
Tokyo 40
The Dalles 38
Jacksonville 37
New York 37
São Paulo 33
Princeton 31
Rome 31
Buffalo 30
Milan 28
Millbury 28
Munich 25
Des Moines 23
Orem 23
Nanjing 22
Dearborn 20
Haiphong 20
Dallas 19
Frankfurt am Main 19
Redondo Beach 17
Nuremberg 16
Da Nang 15
Helsinki 15
Johannesburg 15
Lawrence 15
London 15
Chicago 14
Houston 14
Montreal 13
Atlanta 12
Brooklyn 12
Dong Ket 12
Ottawa 12
Seoul 12
Denver 11
Biên Hòa 10
Phoenix 10
Wilmington 10
Acerra 8
Fairfield 8
Hải Dương 8
Mexico City 8
Poplar 8
Ribeirão Preto 8
Warsaw 8
Brasília 7
Chennai 7
Falkenstein 7
Seo-gu 7
Shenyang 7
Vienna 7
Guayaquil 6
Manchester 6
Nanchang 6
Norwalk 6
Padova 6
Philadelphia 6
Quảng Ngãi 6
Rio de Janeiro 6
Sarno 6
Seattle 6
Toronto 6
Bangkok 5
Can Tho 5
Domicella 5
Formia 5
Hebei 5
Jeddah 5
Lappeenranta 5
New Delhi 5
Padua 5
Redwood City 5
Richmond 5
Salerno 5
Zurich 5
Aversa 4
Belo Horizonte 4
Bengaluru 4
Busan 4
Bắc Giang 4
Capaccio 4
Casablanca 4
Casaluce 4
Totale 3.553
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Nome #
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 661
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) 283
Retinal Degeneration in MPS-IIIA Mouse Model 224
Anti-amyloid treatment is broadly effective in neuronopathic mucopolysaccharidoses and synergizes with gene therapy in MPS-IIIA 206
Treatment of lysosomal storage disorders 181
Phosphorylation-regulated degradation of the tumor-suppressor form of PED by chaperone-mediated autophagy in lung cancer cells 154
Brain Targeting in MPS-IIIA 153
Transcription-dependent association of multiple P-TEFb units to a hexim multimer. 152
Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases 151
Multistep, sequential control of the trafficking and function of the multiple sulfatase deficiency gene product, SUMF1 by PDI, ERGIC-53 and ERp44. 150
Inhibition of lipofuscin aggregation by molecular tweezers 149
Functional inactivation of Cdk9 through oligomerization chain reaction. 142
Enhanced Version of Human Sulfamidase Significantly Ameliorates CNS Pathology When Delivered to the MPS-IIIA Mice by AAV-Mediated Intra-CSF Injection 141
Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders 140
Transdermal spinal catheter placement in piglets: Description and validation of the technique. 133
Access to cerebrospinal fluid in piglets via the cisterna magna: Optimization and description of the technique 133
Functional inactivation of Cdk9 through oligomerization chain reaction 131
Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders 128
Glycosaminoglycan levels and structure in a mucopolysaccharidosis IIIA mice and the effect of a highly secreted sulfamidase engineered to cross the blood-brain barrier 128
Cell trafficking of SUMF1 described by functional proteomics experiments 126
Targeting neuronal proteostasis to treat the CNS in lysosomal storage diseases 125
A comprehensive map of CNS transduction by eight recombinant adeno-associated virus serotypes upon cerebrospinal fluid administration in pigs 124
Inhibition of Tat activity by the HEXIM1 protein. 122
A highly secreted sulphamidase engineered to cross the blood-brain barrier corrects brain lesions of mice with mucopolysaccharidoses type IIIA. 122
Intracerebral Administration of Adeno-Associated Viral Vector Serotype rh.10 Carrying Human SGSH and SUMF1 cDNAs in Children with Mucopolysaccharidosis Type IIIA Disease: Results of a Phase I/II Trial. 120
The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease 118
Protein aggregation and autophagy dysfunction: new lessons from mucopolysaccharidoses 118
A Block of Autophagy in Lysosomal Storage Disorders 117
MAQ1 and 7K RNA interact with CDK9/Cyclin T complexes in a transcription-dependent manner 115
The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease 112
Impaired parkin-mediated mitochondrial targeting to autophagosomes differentially contributes to tissue pathology in lysosomal storage diseases 112
Therapy of sulfatase deficiencies 111
Enhancing the Therapeutic Potential of Sulfamidase for the Treatment of Mucopolysaccharidosis IIIA 111
Distinct regions of cyclinT1 are required for binding to CDK9 and for recruitment to the HIV-1 Tat/TAR complex. 110
Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer. 109
Transcriptional activation of lysosomal exocytosis promotes cellular clearance. 108
Autophagy contributes to inflammation in patients with TNFR-associated periodic syndrome (TRAPS). 106
Gene therapy for mucopolysaccharidoses: in vivo and ex vivo approaches 102
Un giorno alla volta, un'ora alla volta 99
Efficacy of a combined intracerebral and systemic gene delivery approach for the treatment of a severe lysosomal storage disorder. 97
Lysosomal storage diseases as disorders of autophagy 87
Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2 82
Inhibition of Lipofuscin Aggregation by Molecular Tweezers. 82
Sulfatase activities are regulated by the interaction of the sulfatase-modifying factor 1 with SUMF2 80
Functional correction of CNS lesions in an MPS-IIIA mouse model by intracerebral AAV-mediated delivery of sulfamidase and SUMF1 genes. 79
Signals from the lysosome: a control centre for cellular clearance and energy metabolism. 73
Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor 71
In vivo Gene Therapy to the Liver and Nervous System: Promises and Challenges 71
Brain Disorders Due to Lysomal Dysfunction 70
Zinc-α2-glycoprotein hinders cell proliferation and reduces cdc2 expression 68
Istologia Umana 64
SUMF1 enhances sulfatase activities in vivo in five sulfatase deficiencies. 64
Therapeutic strategies to treat CNS pathology in Mucopolysaccharidoses 62
LET’Sanfilippo FIGHTers - Mucopolysaccharidosis 3 Workshop 49
Istologia 48
Protein Aggregation and Dysfunction of Autophagy-Lysosomal Pathway: A Vicious Cycle in Lysosomal Storage Diseases 44
Progressive activation of the astrocyte A1 phenotype underlies microglia-astroglia crosstalk and contributes to neuroinflammation in neuronopathic MPS 36
Commentary: Lysosomal enzymes engineered to cross the blood-brain barrier are reshaping the therapeutic landscape of neuronopathic mucopolysaccharidoses 27
Totale 7.081
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Categoria #
all - tutte 21.416
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 21.416
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022269 0 4 2 9 16 8 3 10 35 15 57 110
2022/2023395 55 55 8 18 47 35 5 34 49 64 21 4
2023/2024302 26 31 81 13 13 22 13 14 11 17 40 21
2024/20251.625 68 104 9 20 42 84 196 109 91 160 559 183
2025/20263.710 354 306 372 420 603 195 377 272 410 195 111 95
2026/2027145 110 35 0 0 0 0 0 0 0 0 0 0
Totale 7.081