IRIS
FRALDI, ALESSANDRO
 Distribuzione geografica
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Continente #
AS - Asia 2.317
EU - Europa 1.968
NA - Nord America 1.967
SA - Sud America 317
AF - Africa 63
OC - Oceania 7
Totale 6.639
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Nazione #
US - Stati Uniti d'America 1.891
SG - Singapore 1.003
IT - Italia 730
RU - Federazione Russa 664
VN - Vietnam 465
CN - Cina 406
BR - Brasile 254
HK - Hong Kong 175
NL - Olanda 117
DE - Germania 98
FR - Francia 92
FI - Finlandia 54
GB - Regno Unito 54
JP - Giappone 43
CA - Canada 40
IN - India 39
BD - Bangladesh 36
UA - Ucraina 36
KR - Corea 35
IE - Irlanda 32
AR - Argentina 22
MX - Messico 22
ZA - Sudafrica 20
ID - Indonesia 18
TR - Turchia 18
PH - Filippine 17
SE - Svezia 17
CH - Svizzera 14
PL - Polonia 14
AT - Austria 13
IQ - Iraq 12
EC - Ecuador 11
CI - Costa d'Avorio 9
PK - Pakistan 8
AU - Australia 7
MA - Marocco 7
PY - Paraguay 7
TH - Thailandia 7
UY - Uruguay 7
DZ - Algeria 6
ES - Italia 6
SA - Arabia Saudita 6
BE - Belgio 5
KE - Kenya 5
AL - Albania 4
BO - Bolivia 4
LB - Libano 4
LT - Lituania 4
NG - Nigeria 4
PE - Perù 4
TW - Taiwan 4
AZ - Azerbaigian 3
CL - Cile 3
CO - Colombia 3
IR - Iran 3
MY - Malesia 3
NP - Nepal 3
RO - Romania 3
AE - Emirati Arabi Uniti 2
BF - Burkina Faso 2
BG - Bulgaria 2
BH - Bahrain 2
BY - Bielorussia 2
BZ - Belize 2
CR - Costa Rica 2
EG - Egitto 2
ET - Etiopia 2
PA - Panama 2
SN - Senegal 2
TN - Tunisia 2
TT - Trinidad e Tobago 2
VE - Venezuela 2
CU - Cuba 1
CY - Cipro 1
CZ - Repubblica Ceca 1
DK - Danimarca 1
GA - Gabon 1
GE - Georgia 1
GR - Grecia 1
HN - Honduras 1
HR - Croazia 1
IL - Israele 1
JM - Giamaica 1
KZ - Kazakistan 1
LI - Liechtenstein 1
MD - Moldavia 1
NI - Nicaragua 1
PR - Porto Rico 1
PT - Portogallo 1
SC - Seychelles 1
SY - Repubblica araba siriana 1
VC - Saint Vincent e Grenadine 1
Totale 6.639
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Città #
Singapore 468
San Jose 325
Naples 259
Chandler 167
Hong Kong 161
Ashburn 144
Moscow 138
Ho Chi Minh City 137
Beijing 119
Santa Clara 104
Hanoi 90
Amsterdam 81
Hefei 62
Los Angeles 51
Lauterbourg 49
Napoli 49
Boston 45
Council Bluffs 39
The Dalles 38
Tokyo 38
Jacksonville 37
New York 34
Princeton 31
São Paulo 31
Buffalo 29
Rome 29
Millbury 28
Milan 26
Munich 25
Des Moines 23
Orem 23
Nanjing 22
Dearborn 20
Haiphong 20
Frankfurt am Main 19
Dallas 17
Redondo Beach 17
Nuremberg 16
Da Nang 15
Helsinki 15
Johannesburg 15
Lawrence 15
London 15
Chicago 13
Houston 13
Brooklyn 12
Dong Ket 12
Montreal 12
Ottawa 12
Seoul 12
Atlanta 11
Denver 11
Biên Hòa 10
Wilmington 10
Acerra 8
Fairfield 8
Hải Dương 8
Mexico City 8
Poplar 8
Warsaw 8
Brasília 7
Chennai 7
Falkenstein 7
Phoenix 7
Ribeirão Preto 7
Seo-gu 7
Shenyang 7
Vienna 7
Manchester 6
Nanchang 6
Padova 6
Quảng Ngãi 6
Rio de Janeiro 6
Sarno 6
Seattle 6
Toronto 6
Bangkok 5
Can Tho 5
Domicella 5
Formia 5
Guayaquil 5
Hebei 5
Jeddah 5
Lappeenranta 5
New Delhi 5
Norwalk 5
Padua 5
Philadelphia 5
Redwood City 5
Salerno 5
Zurich 5
Aversa 4
Belo Horizonte 4
Bengaluru 4
Busan 4
Bắc Giang 4
Capaccio 4
Casablanca 4
Casaluce 4
Caxias do Sul 4
Totale 3.477
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Nome #
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 633
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) 273
Retinal Degeneration in MPS-IIIA Mouse Model 219
Anti-amyloid treatment is broadly effective in neuronopathic mucopolysaccharidoses and synergizes with gene therapy in MPS-IIIA 200
Treatment of lysosomal storage disorders 178
Phosphorylation-regulated degradation of the tumor-suppressor form of PED by chaperone-mediated autophagy in lung cancer cells 153
Brain Targeting in MPS-IIIA 150
Transcription-dependent association of multiple P-TEFb units to a hexim multimer. 148
Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases 148
Multistep, sequential control of the trafficking and function of the multiple sulfatase deficiency gene product, SUMF1 by PDI, ERGIC-53 and ERp44. 147
Inhibition of lipofuscin aggregation by molecular tweezers 147
Functional inactivation of Cdk9 through oligomerization chain reaction. 142
Enhanced Version of Human Sulfamidase Significantly Ameliorates CNS Pathology When Delivered to the MPS-IIIA Mice by AAV-Mediated Intra-CSF Injection 137
Access to cerebrospinal fluid in piglets via the cisterna magna: Optimization and description of the technique 132
Functional inactivation of Cdk9 through oligomerization chain reaction 131
Transdermal spinal catheter placement in piglets: Description and validation of the technique. 131
Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders 129
Cell trafficking of SUMF1 described by functional proteomics experiments 126
Glycosaminoglycan levels and structure in a mucopolysaccharidosis IIIA mice and the effect of a highly secreted sulfamidase engineered to cross the blood-brain barrier 126
Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders 125
Inhibition of Tat activity by the HEXIM1 protein. 122
A highly secreted sulphamidase engineered to cross the blood-brain barrier corrects brain lesions of mice with mucopolysaccharidoses type IIIA. 122
Targeting neuronal proteostasis to treat the CNS in lysosomal storage diseases 122
A comprehensive map of CNS transduction by eight recombinant adeno-associated virus serotypes upon cerebrospinal fluid administration in pigs 120
Intracerebral Administration of Adeno-Associated Viral Vector Serotype rh.10 Carrying Human SGSH and SUMF1 cDNAs in Children with Mucopolysaccharidosis Type IIIA Disease: Results of a Phase I/II Trial. 117
A Block of Autophagy in Lysosomal Storage Disorders 116
The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease 116
MAQ1 and 7K RNA interact with CDK9/Cyclin T complexes in a transcription-dependent manner 115
Therapy of sulfatase deficiencies 110
The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease 108
Transcriptional activation of lysosomal exocytosis promotes cellular clearance. 108
Distinct regions of cyclinT1 are required for binding to CDK9 and for recruitment to the HIV-1 Tat/TAR complex. 108
Protein aggregation and autophagy dysfunction: new lessons from mucopolysaccharidoses 108
Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer. 107
Impaired parkin-mediated mitochondrial targeting to autophagosomes differentially contributes to tissue pathology in lysosomal storage diseases 107
Enhancing the Therapeutic Potential of Sulfamidase for the Treatment of Mucopolysaccharidosis IIIA 107
Autophagy contributes to inflammation in patients with TNFR-associated periodic syndrome (TRAPS). 102
Un giorno alla volta, un'ora alla volta 97
Efficacy of a combined intracerebral and systemic gene delivery approach for the treatment of a severe lysosomal storage disorder. 97
Gene therapy for mucopolysaccharidoses: in vivo and ex vivo approaches 97
Lysosomal storage diseases as disorders of autophagy 85
Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2 79
Sulfatase activities are regulated by the interaction of the sulfatase-modifying factor 1 with SUMF2 79
Inhibition of Lipofuscin Aggregation by Molecular Tweezers. 79
Functional correction of CNS lesions in an MPS-IIIA mouse model by intracerebral AAV-mediated delivery of sulfamidase and SUMF1 genes. 78
Signals from the lysosome: a control centre for cellular clearance and energy metabolism. 71
In vivo Gene Therapy to the Liver and Nervous System: Promises and Challenges 70
Brain Disorders Due to Lysomal Dysfunction 69
Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor 69
Zinc-α2-glycoprotein hinders cell proliferation and reduces cdc2 expression 66
SUMF1 enhances sulfatase activities in vivo in five sulfatase deficiencies. 64
Therapeutic strategies to treat CNS pathology in Mucopolysaccharidoses 62
LET’Sanfilippo FIGHTers - Mucopolysaccharidosis 3 Workshop 49
Istologia Umana 48
Protein Aggregation and Dysfunction of Autophagy-Lysosomal Pathway: A Vicious Cycle in Lysosomal Storage Diseases 42
Progressive activation of the astrocyte A1 phenotype underlies microglia-astroglia crosstalk and contributes to neuroinflammation in neuronopathic MPS 34
Istologia 34
Commentary: Lysosomal enzymes engineered to cross the blood-brain barrier are reshaping the therapeutic landscape of neuronopathic mucopolysaccharidoses 18
Totale 6.877
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Categoria #
all - tutte 19.874
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 19.874
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202115 0 0 0 0 0 0 0 0 0 0 0 15
2021/2022280 11 4 2 9 16 8 3 10 35 15 57 110
2022/2023395 55 55 8 18 47 35 5 34 49 64 21 4
2023/2024302 26 31 81 13 13 22 13 14 11 17 40 21
2024/20251.625 68 104 9 20 42 84 196 109 91 160 559 183
2025/20263.651 354 306 372 420 603 195 377 272 410 195 111 36
Totale 6.877