Atopic dermatitis (AD) is a highly prevalent chronic inflammatory skin disease characterized by pruritus and eczematous skin lesions. Considering that hydrogen sulfide (H2S) is produced in the skin and participates of several processes, such as the regulation of inflammation, pruritus, scarring, and angiogenesis (Coavoy-Sánchez, Costa, Muscará, 2019), we decided to test the effects of a H2S-releasing dexamethasone (Dexa) derivative in a murine model of AD.
A hydrogen sulfide-releasing dexamethasone derivative attenuates atopic dermatitis severity signs and the associated oxidative stress markers in mice / Santagada, Vincenzo; Caliendo, Giuseppe; Severino, Beatrice. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 1476-5381. - 177:11(2020), pp. 2571-2572. [10.1111/bph.15035]
A hydrogen sulfide-releasing dexamethasone derivative attenuates atopic dermatitis severity signs and the associated oxidative stress markers in mice
Santagada Vincenzo;Caliendo Giuseppe;Severino Beatrice
2020
Abstract
Atopic dermatitis (AD) is a highly prevalent chronic inflammatory skin disease characterized by pruritus and eczematous skin lesions. Considering that hydrogen sulfide (H2S) is produced in the skin and participates of several processes, such as the regulation of inflammation, pruritus, scarring, and angiogenesis (Coavoy-Sánchez, Costa, Muscará, 2019), we decided to test the effects of a H2S-releasing dexamethasone (Dexa) derivative in a murine model of AD.| File | Dimensione | Formato | |
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