Chiariello et al. use polymer physics models to infer the 3D conformations of the murine α-globin locus. In the transition from ESCs to erythroid cells, the locus rearranges from an inactive highly intermingled conformation to an active, hairpin-shaped structure, marked by cell-specific three-way contacts accurately predicted by the models.
A Dynamic Folded Hairpin Conformation Is Associated with α-Globin Activation in Erythroid Cells / Chiariello, A. M.; Bianco, S.; Oudelaar, A. M.; Esposito, A.; Annunziatella, C.; Fiorillo, L.; Conte, M.; Corrado, A.; Prisco, A.; Larke, M. S. C.; Telenius, J. M.; Sciarretta, R.; Musella, F.; Buckle, V. J.; Higgs, D. R.; Hughes, J. R.; Nicodemi, M.. - In: CELL REPORTS. - ISSN 2211-1247. - 30:7(2020), pp. 2125-2135.e5. [10.1016/j.celrep.2020.01.044]
A Dynamic Folded Hairpin Conformation Is Associated with α-Globin Activation in Erythroid Cells
Chiariello A. M.;Bianco S.;Esposito A.;Annunziatella C.;Fiorillo L.;Conte M.;Sciarretta R.;Musella F.;Nicodemi M.
2020
Abstract
Chiariello et al. use polymer physics models to infer the 3D conformations of the murine α-globin locus. In the transition from ESCs to erythroid cells, the locus rearranges from an inactive highly intermingled conformation to an active, hairpin-shaped structure, marked by cell-specific three-way contacts accurately predicted by the models.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
