The depth and complexity of data now available on chromosome 3D architecture, derived by new technologies such as Hi-C, have triggered the development of models based on polymer physics to explain the observed patterns and the underly- ing molecular folding mechanisms. Here, we give an overview of some of the ideas and models from physics introduced to date, along with their progresses and limitations in the description of experimental data. In particular, we focus on the Strings&Binders and the Loop Extrusion model of chromatin architecture.

Models of polymer physics for the architecture of the cell nucleus

Esposito, Andrea;Annunziatella, Carlo;Bianco, Simona;Chiariello, Andrea M.;Fiorillo, Luca;Nicodemi, Mario
2019

Abstract

The depth and complexity of data now available on chromosome 3D architecture, derived by new technologies such as Hi-C, have triggered the development of models based on polymer physics to explain the observed patterns and the underly- ing molecular folding mechanisms. Here, we give an overview of some of the ideas and models from physics introduced to date, along with their progresses and limitations in the description of experimental data. In particular, we focus on the Strings&Binders and the Loop Extrusion model of chromatin architecture.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11588/728751
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