IRIS
CERCHIA, CARMEN
 Distribuzione geografica
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Continente #
NA - Nord America 647
EU - Europa 458
AS - Asia 370
AF - Africa 29
SA - Sud America 3
OC - Oceania 1
Totale 1.508
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Nazione #
US - Stati Uniti d'America 639
IT - Italia 282
SG - Singapore 159
HK - Hong Kong 95
CN - Cina 89
IE - Irlanda 33
NL - Olanda 31
FI - Finlandia 27
CI - Costa d'Avorio 25
GB - Regno Unito 18
DE - Germania 15
RU - Federazione Russa 15
SE - Svezia 9
CA - Canada 8
FR - Francia 8
IN - India 7
TR - Turchia 7
VN - Vietnam 4
ES - Italia 3
KR - Corea 3
RO - Romania 3
RS - Serbia 3
AR - Argentina 2
AT - Austria 2
BE - Belgio 2
EG - Egitto 2
LV - Lettonia 2
NP - Nepal 2
TW - Taiwan 2
AU - Australia 1
BD - Bangladesh 1
CL - Cile 1
CZ - Repubblica Ceca 1
DZ - Algeria 1
GR - Grecia 1
HR - Croazia 1
IR - Iran 1
LS - Lesotho 1
PL - Polonia 1
UA - Ucraina 1
Totale 1.508
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Città #
Singapore 135
Chandler 93
Hong Kong 92
Santa Clara 61
Naples 55
Ashburn 51
Napoli 45
Millbury 43
Amsterdam 30
Des Moines 29
Beijing 24
Princeton 20
Lawrence 16
Salerno 16
Nanjing 15
Boston 13
Rome 11
Wilmington 11
Helsinki 8
Hebei 6
Shenyang 6
Casoria 5
Falls Church 5
Guangzhou 5
Milan 5
Ottawa 5
Seattle 5
Buccino 4
Cologne 4
Dong Ket 4
Enfield 4
Fairfield 4
Frankfurt am Main 4
Nanchang 4
Pune 4
Redwood City 4
Çanakkale 4
Avellino 3
Busto Arsizio 3
Casavatore 3
Changsha 3
Dublin 3
Jiaxing 3
Lancaster 3
Lappeenranta 3
London 3
Los Angeles 3
Moscow 3
Norwalk 3
Rimini 3
Sevilla 3
Agropoli 2
Ann Arbor 2
Asyut 2
Bahía Blanca 2
Bari 2
Bastia umbra 2
Belgrade 2
Bell Gardens 2
Boardman 2
Brescia 2
Brussels 2
Camerino 2
Catanzaro 2
Chuncheon 2
Dallas 2
Ferrara 2
Genova 2
Hefei 2
Lubhu 2
Mablethorpe 2
Messina 2
Montreal 2
Mumbai 2
Oristano 2
Palermo 2
Pisa 2
Redmond 2
Riga 2
Shijiazhuang 2
Siano 2
Siena 2
Stockholm 2
Tianjin 2
Yellow Springs 2
Zhengzhou 2
Arezzo 1
Atlanta 1
Baoding 1
Baronissi 1
Belmonte Mezzagno 1
Benevento 1
Bonn 1
Caserta 1
Castellammare Di Stabia 1
Cava De' Tirreni 1
Cernobbio 1
Cerro Maggiore 1
Chiampo 1
Chittagong 1
Totale 976
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Nome #
App maturation and intracellular localization are controlled by a specific inhibitor of 37/67 kda laminin-1 receptor in neuronal cells 63
A compound-based proteomic approach discloses 15-ketoatractyligenin methyl ester as a new PPARγ partial agonist with anti-proliferative ability 62
Novel Non-Peptide Small Molecules Preventing IKKβ/NEMO Association Inhibit NF-κB Activation in LPS-Stimulated J774 Macrophages 59
Discovery of a Novel Small Molecule Inhibitor Targeting the Frataxin/Ubiquitin Interaction via Structure-Based Virtual Screening and Bioassays 57
Cdc25 inhibitors in melanoma cells 56
Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines 56
Targeting SARS-CoV-2 Proteases and Polymerase for COVID-19 Treatment: State of the Art and Future Opportunities 52
Ligand-based chemoinformatic discovery of a novel small molecule inhibitor targeting CDC25 dual specificity phosphatases and displaying in vitro efficacy against melanoma cells 50
Unlocking the Potential of Generative Artificial Intelligence in Drug Discovery 49
Discovery Of Novel Peroxisome Proliferator-Activated Receptor γ (PPARγ) Scaffolds With Partial Agonist Binding Properties By Integrated In Silico/In Vitro Work Flow 46
In silico methods to address polypharmacology: Current status, applications and future perspectives 46
Easy access to α-ketoamides as SARS-CoV-2 and MERS Mpro inhibitors via the PADAM oxidation route 43
The antiproliferative and proapoptotic effects of cladosporols A and B are related to their different binding mode as PPARγ ligands 43
Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination 42
SARS-CoV-2 Entry Inhibitors: Small Molecules and Peptides Targeting Virus or Host Cells 41
Antitumor agents 7. Synthesis, antiproliferative activity and molecular modeling of new L-lysine-conjugated pyridophenoxazinones as potent DNA-binding ligands and topoisomerase IIα inhibitors 39
Small Molecule Drugs And Targeted Therapy For Melanoma: Current Strategies And Future Directions 38
Exploring the Role of N(6)-Substituents in Potent Dual Acting 5'-C-Ethyltetrazolyladenosine Derivatives: Synthesis, Binding, Functional Assays, and Antinociceptive Effects in Mice 36
Identification of a new series of amides as non-covalent proteasome inhibitors 35
In Silico Identification of Novel Inhibitors Targeting the Homodimeric Interface of Superoxide Dismutase from the Dental Pathogen Streptococcus mutans 34
Development of Novel Selective Peptidomimetics Containing a Boronic Acid Moiety, Targeting the 20S Proteasome as Anticancer Agents 34
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity 31
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode 30
Characterization of novel inhibitors of CDC25 phosphatases: biochemical and biological analysis 29
Selective PPARγ modulators for Type 2 diabetes treatment: How far have we come and what does the future hold? 27
Computational studies of SARS-CoV-2 3clpro: Insights from md simulations 27
Novel Reversible Inhibitors of Xanthine Oxidase Targeting the Active Site of the Enzyme 26
null 26
Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors 25
Development of novel amides as noncovalent inhibitors of immunoproteasomes 23
Identification of selective 5-LOX and FLAP inhibitors as novel anti-inflammatory agents by ligand-based virtual screening 22
Novel inhibitors of signal transducer and activator of transcription 3 signaling pathway: an update on the recent patent literature 22
Exploring structural relationships between bioactive and commercial chemical space and developing target hypotheses for compound acquisition 22
Sulfonimide and amide derivatives as novel PPARα antagonists: Synthesis, antiproliferative activity, and docking studies 22
Altered Local Interactions and Long-Range Communications in UK Variant (B.1.1.7) Spike Glycoprotein 22
A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity 22
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition 21
Binding mode exploration of b1 receptor antagonists’ by the use of molecular dynamics and docking simulation—how different target engagement can determine different biological effects 21
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome 21
Identification of the First PPARα/γ Dual Agonist Able to Bind to Canonical and Alternate Sites of PPARγ and to Inhibit its Cdk5-Mediated Phosphorylation 20
Chiral phenoxyacetic acid analogues inhibit colon cancer cell proliferation acting as PPARγ partial agonists 20
New avenues in artificial-intelligence-assisted drug discovery 19
A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects 18
Deep generative models in the quest for anticancer drugs: ways forward 17
“Molecular Anatomy”: a new multi-dimensional hierarchical scaffold analysis tool 17
Methyl-Transferase-Like Protein 16 (METTL16): The Intriguing Journey of a Key Epitranscriptomic Player Becoming an Emerging Biological Target 16
Impairment of Nucleolin Activity and Phosphorylation by a Trachylobane Diterpene from Psiadia punctulata in Cancer Cells 16
In Silico Drug Design and Discovery: Big Data for Small Molecule Design 12
Recent advances in developing PCSK9 inhibitors for lipid-lowering therapy 11
“DompeKeys”: a set of novel substructure-based descriptors for efficient chemical space mapping, development and structural interpretation of machine learning models, and indexing of large databases 9
A chemical modification of a peroxisome proliferator-activated receptor pan agonist produced a shift to a new dual alpha/gamma partial agonist endowed with mitochondrial pyruvate carrier inhibition and antidiabetic properties 9
Enhancing De Novo Drug Design across Multiple Therapeutic Targets with CVAE Generative Models 9
Synthesis and in vitro cytotoxicity of benzoxazole‐based PPARα/γ antagonists in colorectal cancer cell lines 8
Editorial: Recent trends in anti-cancer drug discovery by in silico methods 6
A sulfonimide derivative of bezafibrate as a dual inhibitor of cyclooxygenase-2 and PPARα 4
Totale 1.631
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Categoria #
all - tutte 7.463
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 7.463
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/202042 0 0 0 0 0 0 0 0 4 13 20 5
2020/202194 1 0 1 4 36 14 1 1 12 7 9 8
2021/2022257 2 3 6 8 18 11 1 4 53 3 51 97
2022/2023285 36 15 17 23 15 30 7 27 40 33 22 20
2023/2024282 18 23 27 22 6 19 8 70 3 4 61 21
2024/2025454 65 85 14 24 51 93 122 0 0 0 0 0
Totale 1.631