IRIS
CERCHIA, CARMEN
 Distribuzione geografica
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Continente #
AS - Asia 1.699
EU - Europa 1.294
NA - Nord America 1.272
SA - Sud America 198
AF - Africa 56
Continente sconosciuto - Info sul continente non disponibili 2
OC - Oceania 2
Totale 4.523
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Nazione #
US - Stati Uniti d'America 1.221
SG - Singapore 944
RU - Federazione Russa 629
CN - Cina 408
IT - Italia 366
BR - Brasile 155
HK - Hong Kong 119
VN - Vietnam 109
DE - Germania 59
FI - Finlandia 44
NL - Olanda 40
GB - Regno Unito 38
IE - Irlanda 34
KR - Corea 30
CI - Costa d'Avorio 27
CA - Canada 21
IN - India 21
MX - Messico 20
FR - Francia 19
SE - Svezia 15
AR - Argentina 14
ZA - Sudafrica 12
AT - Austria 10
ID - Indonesia 10
JP - Giappone 8
TR - Turchia 8
ES - Italia 7
IQ - Iraq 7
BD - Bangladesh 6
PL - Polonia 6
CL - Cile 5
EC - Ecuador 5
PY - Paraguay 5
VE - Venezuela 5
BE - Belgio 4
LT - Lituania 4
NP - Nepal 4
RO - Romania 4
UA - Ucraina 4
CO - Colombia 3
KH - Cambogia 3
MA - Marocco 3
PK - Pakistan 3
RS - Serbia 3
UZ - Uzbekistan 3
AE - Emirati Arabi Uniti 2
AU - Australia 2
BO - Bolivia 2
BS - Bahamas 2
CY - Cipro 2
CZ - Repubblica Ceca 2
EG - Egitto 2
JM - Giamaica 2
JO - Giordania 2
LV - Lettonia 2
PE - Perù 2
SA - Arabia Saudita 2
TW - Taiwan 2
UG - Uganda 2
UY - Uruguay 2
XK - ???statistics.table.value.countryCode.XK??? 2
AZ - Azerbaigian 1
BN - Brunei Darussalam 1
CR - Costa Rica 1
CU - Cuba 1
DM - Dominica 1
DZ - Algeria 1
GM - Gambi 1
GP - Guadalupe 1
GR - Grecia 1
HR - Croazia 1
IR - Iran 1
KE - Kenya 1
KG - Kirghizistan 1
KZ - Kazakistan 1
LS - Lesotho 1
LY - Libia 1
MD - Moldavia 1
MW - Malawi 1
NE - Niger 1
NG - Nigeria 1
NI - Nicaragua 1
SK - Slovacchia (Repubblica Slovacca) 1
TH - Thailandia 1
TN - Tunisia 1
TT - Trinidad e Tobago 1
TZ - Tanzania 1
Totale 4.523
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Città #
Singapore 477
Moscow 146
Hefei 143
Ashburn 132
Dallas 127
Hong Kong 116
San Jose 105
Beijing 95
Chandler 93
Naples 82
Santa Clara 67
Napoli 45
Millbury 43
Ho Chi Minh City 36
Amsterdam 34
Los Angeles 34
Des Moines 29
Hanoi 27
Seoul 27
Milan 22
Buffalo 20
Princeton 20
Redondo Beach 20
São Paulo 20
Boston 17
New York 17
Lawrence 16
Nanjing 16
Rome 16
Salerno 16
Helsinki 14
Munich 14
Nuremberg 12
Wilmington 12
Brooklyn 11
Mexico City 11
Frankfurt am Main 10
Orem 10
Montreal 9
Chicago 8
Haiphong 8
London 8
Stockholm 8
The Dalles 8
Guangzhou 7
Vienna 7
Atlanta 6
Hebei 6
Johannesburg 6
Ottawa 6
Seattle 6
Shenyang 6
Turku 6
Belo Horizonte 5
Casoria 5
Falkenstein 5
Falls Church 5
Goiânia 5
Kochi 5
Lappeenranta 5
Phoenix 5
Shanghai 5
Tokyo 5
Bologna 4
Brussels 4
Buccino 4
Changsha 4
Cologne 4
Dong Ket 4
Dublin 4
Enfield 4
Fairfield 4
Fisciano 4
Mumbai 4
Nanchang 4
Pune 4
Querétaro 4
Redwood City 4
San Francisco 4
Warsaw 4
Çanakkale 4
Avellino 3
Baghdad 3
Buenos Aires 3
Busto Arsizio 3
Cagliari 3
Camerino 3
Campinas 3
Canoas 3
Casavatore 3
Denver 3
Guarulhos 3
Hải Dương 3
Jiaxing 3
Kyoto 3
Lancaster 3
Manchester 3
Norwalk 3
Phnom Penh 3
Quảng Ngãi 3
Totale 2.436
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Nome #
Unlocking the Potential of Generative Artificial Intelligence in Drug Discovery 156
Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination 145
Discovery of a Novel Small Molecule Inhibitor Targeting the Frataxin/Ubiquitin Interaction via Structure-Based Virtual Screening and Bioassays 126
Novel Non-Peptide Small Molecules Preventing IKKβ/NEMO Association Inhibit NF-κB Activation in LPS-Stimulated J774 Macrophages 126
A compound-based proteomic approach discloses 15-ketoatractyligenin methyl ester as a new PPARγ partial agonist with anti-proliferative ability 124
Cdc25 inhibitors in melanoma cells 121
App maturation and intracellular localization are controlled by a specific inhibitor of 37/67 kda laminin-1 receptor in neuronal cells 119
Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines 115
Novel Reversible Inhibitors of Xanthine Oxidase Targeting the Active Site of the Enzyme 114
Ligand-based chemoinformatic discovery of a novel small molecule inhibitor targeting CDC25 dual specificity phosphatases and displaying in vitro efficacy against melanoma cells 113
Discovery Of Novel Peroxisome Proliferator-Activated Receptor γ (PPARγ) Scaffolds With Partial Agonist Binding Properties By Integrated In Silico/In Vitro Work Flow 112
SARS-CoV-2 Entry Inhibitors: Small Molecules and Peptides Targeting Virus or Host Cells 106
In Silico Identification of Novel Inhibitors Targeting the Homodimeric Interface of Superoxide Dismutase from the Dental Pathogen Streptococcus mutans 99
Characterization of novel inhibitors of CDC25 phosphatases: biochemical and biological analysis 98
Antitumor agents 7. Synthesis, antiproliferative activity and molecular modeling of new L-lysine-conjugated pyridophenoxazinones as potent DNA-binding ligands and topoisomerase IIα inhibitors 96
Easy access to α-ketoamides as SARS-CoV-2 and MERS Mpro inhibitors via the PADAM oxidation route 95
The antiproliferative and proapoptotic effects of cladosporols A and B are related to their different binding mode as PPARγ ligands 95
Methyl-Transferase-Like Protein 16 (METTL16): The Intriguing Journey of a Key Epitranscriptomic Player Becoming an Emerging Biological Target 93
Small Molecule Drugs And Targeted Therapy For Melanoma: Current Strategies And Future Directions 93
Development of Novel Selective Peptidomimetics Containing a Boronic Acid Moiety, Targeting the 20S Proteasome as Anticancer Agents 92
Identification of a new series of amides as non-covalent proteasome inhibitors 91
Identification of selective 5-LOX and FLAP inhibitors as novel anti-inflammatory agents by ligand-based virtual screening 90
Targeting SARS-CoV-2 Proteases and Polymerase for COVID-19 Treatment: State of the Art and Future Opportunities 90
Deep generative models in the quest for anticancer drugs: ways forward 88
In silico methods to address polypharmacology: Current status, applications and future perspectives 85
Chiral phenoxyacetic acid analogues inhibit colon cancer cell proliferation acting as PPARγ partial agonists 85
Synthesis and in vitro cytotoxicity of benzoxazole‐based PPARα/γ antagonists in colorectal cancer cell lines 84
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity 84
Development of novel amides as noncovalent inhibitors of immunoproteasomes 83
Novel inhibitors of signal transducer and activator of transcription 3 signaling pathway: an update on the recent patent literature 82
Sulfonimide and amide derivatives as novel PPARα antagonists: Synthesis, antiproliferative activity, and docking studies 81
Exploring structural relationships between bioactive and commercial chemical space and developing target hypotheses for compound acquisition 78
Selective PPARγ modulators for Type 2 diabetes treatment: How far have we come and what does the future hold? 77
A chemical modification of a peroxisome proliferator-activated receptor pan agonist produced a shift to a new dual alpha/gamma partial agonist endowed with mitochondrial pyruvate carrier inhibition and antidiabetic properties 74
Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors 74
Altered Local Interactions and Long-Range Communications in UK Variant (B.1.1.7) Spike Glycoprotein 74
Impairment of Nucleolin Activity and Phosphorylation by a Trachylobane Diterpene from Psiadia punctulata in Cancer Cells 72
Enhancing De Novo Drug Design across Multiple Therapeutic Targets with CVAE Generative Models 71
Exploring the Role of N(6)-Substituents in Potent Dual Acting 5'-C-Ethyltetrazolyladenosine Derivatives: Synthesis, Binding, Functional Assays, and Antinociceptive Effects in Mice 65
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome 65
New avenues in artificial-intelligence-assisted drug discovery 62
“DompeKeys”: a set of novel substructure-based descriptors for efficient chemical space mapping, development and structural interpretation of machine learning models, and indexing of large databases 61
In Silico Drug Design and Discovery: Big Data for Small Molecule Design 61
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition 61
Computational studies of SARS-CoV-2 3clpro: Insights from md simulations 61
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode 59
“Molecular Anatomy”: a new multi-dimensional hierarchical scaffold analysis tool 57
Binding mode exploration of b1 receptor antagonists’ by the use of molecular dynamics and docking simulation—how different target engagement can determine different biological effects 53
Recent advances in developing PCSK9 inhibitors for lipid-lowering therapy 53
A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity 53
A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects 50
A sulfonimide derivative of bezafibrate as a dual inhibitor of cyclooxygenase-2 and PPARα 47
Identification of the First PPARα/γ Dual Agonist Able to Bind to Canonical and Alternate Sites of PPARγ and to Inhibit its Cdk5-Mediated Phosphorylation 47
Editorial: Recent trends in anti-cancer drug discovery by in silico methods 45
null 26
Challenging triple negative breast cancer through HDAC6 selective inhibition: Novel cap-group identification, structure-activity relationships, computational and biological studies 21
Totale 4.648
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Categoria #
all - tutte 14.825
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 14.825
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202138 0 0 0 0 0 0 1 1 12 7 9 8
2021/2022257 2 3 6 8 18 11 1 4 53 3 51 97
2022/2023285 36 15 17 23 15 30 7 27 40 33 22 20
2023/2024282 18 23 27 22 6 19 8 70 3 4 61 21
2024/20251.533 65 85 14 24 51 93 199 112 62 120 562 146
2025/20261.938 295 241 401 270 462 146 123 0 0 0 0 0
Totale 4.648