IRIS
CERCHIA, CARMEN
 Distribuzione geografica
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Continente #
AS - Asia 2.180
NA - Nord America 2.070
EU - Europa 1.520
SA - Sud America 237
Continente sconosciuto - Info sul continente non disponibili 140
AF - Africa 66
OC - Oceania 2
Totale 6.215
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Nazione #
US - Stati Uniti d'America 1.972
SG - Singapore 998
RU - Federazione Russa 632
IT - Italia 496
CN - Cina 456
VN - Vietnam 300
BR - Brasile 172
HK - Hong Kong 136
DE - Germania 70
BD - Bangladesh 69
FR - Francia 69
CA - Canada 55
FI - Finlandia 48
GB - Regno Unito 47
NL - Olanda 45
JP - Giappone 37
IE - Irlanda 35
KR - Corea 35
IN - India 34
CI - Costa d'Avorio 27
MX - Messico 22
IQ - Iraq 21
ZA - Sudafrica 17
AR - Argentina 16
SE - Svezia 16
VE - Venezuela 14
ID - Indonesia 12
AT - Austria 11
TR - Turchia 10
PH - Filippine 9
PK - Pakistan 9
CL - Cile 8
EC - Ecuador 8
ES - Italia 8
TH - Thailandia 8
TW - Taiwan 8
PL - Polonia 7
CO - Colombia 6
PY - Paraguay 6
JO - Giordania 5
NP - Nepal 5
SA - Arabia Saudita 5
UA - Ucraina 5
BE - Belgio 4
KH - Cambogia 4
LT - Lituania 4
RO - Romania 4
BS - Bahamas 3
CY - Cipro 3
EG - Egitto 3
MA - Marocco 3
MY - Malesia 3
PE - Perù 3
RS - Serbia 3
TN - Tunisia 3
UZ - Uzbekistan 3
AE - Emirati Arabi Uniti 2
AU - Australia 2
BO - Bolivia 2
BY - Bielorussia 2
CH - Svizzera 2
CZ - Repubblica Ceca 2
GT - Guatemala 2
HN - Honduras 2
JM - Giamaica 2
LV - Lettonia 2
MD - Moldavia 2
NI - Nicaragua 2
SV - El Salvador 2
UG - Uganda 2
UY - Uruguay 2
XK - ???statistics.table.value.countryCode.XK??? 2
AM - Armenia 1
AW - Aruba 1
AZ - Azerbaigian 1
BG - Bulgaria 1
BN - Brunei Darussalam 1
CR - Costa Rica 1
CU - Cuba 1
DM - Dominica 1
DZ - Algeria 1
GD - Grenada 1
GE - Georgia 1
GM - Gambi 1
GP - Guadalupe 1
GR - Grecia 1
HR - Croazia 1
HU - Ungheria 1
IR - Iran 1
KE - Kenya 1
KG - Kirghizistan 1
KZ - Kazakistan 1
LS - Lesotho 1
LY - Libia 1
MN - Mongolia 1
MW - Malawi 1
NE - Niger 1
NG - Nigeria 1
NO - Norvegia 1
PR - Porto Rico 1
Totale 6.072
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Città #
Singapore 504
San Jose 443
Ashburn 219
Moscow 146
Hefei 143
Naples 140
Dallas 135
Hong Kong 131
Beijing 108
Chandler 93
Ho Chi Minh City 85
Santa Clara 78
Hanoi 71
Council Bluffs 65
Napoli 45
Lauterbourg 43
Millbury 43
Los Angeles 40
Amsterdam 35
Tokyo 33
The Dalles 31
Milan 30
Des Moines 29
New York 28
Seoul 27
Buffalo 24
São Paulo 23
Phoenix 21
Princeton 20
Redondo Beach 20
Rome 20
Boston 18
Helsinki 17
Salerno 17
Frankfurt am Main 16
Lawrence 16
Nanjing 16
Brooklyn 14
Montreal 14
Munich 14
Orem 14
Atlanta 13
Chicago 13
Wilmington 13
Haiphong 12
Mexico City 12
Nuremberg 12
London 11
Toronto 10
Baghdad 9
Johannesburg 9
Stockholm 9
Seattle 8
Vienna 8
Can Tho 7
Da Nang 7
Falkenstein 7
Guangzhou 7
Ottawa 7
Belo Horizonte 6
Biên Hòa 6
Charlotte 6
Hebei 6
Philadelphia 6
Shenyang 6
Turku 6
Bologna 5
Casoria 5
Changsha 5
Dublin 5
Falls Church 5
Goiânia 5
Houston 5
Hải Dương 5
Kochi 5
Lappeenranta 5
Manchester 5
Shanghai 5
Tampa 5
Avellino 4
Bangkok 4
Brussels 4
Buccino 4
Bắc Ninh 4
Cologne 4
Dong Ket 4
Enfield 4
Fairfield 4
Fisciano 4
Guayaquil 4
Mumbai 4
Nanchang 4
Palermo 4
Phnom Penh 4
Portland 4
Pune 4
Qingdao 4
Querétaro 4
Quảng Ngãi 4
Redwood City 4
Totale 3.394
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Nome #
Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination 189
Unlocking the Potential of Generative Artificial Intelligence in Drug Discovery 187
Novel Non-Peptide Small Molecules Preventing IKKβ/NEMO Association Inhibit NF-κB Activation in LPS-Stimulated J774 Macrophages 161
Cdc25 inhibitors in melanoma cells 159
Discovery of a Novel Small Molecule Inhibitor Targeting the Frataxin/Ubiquitin Interaction via Structure-Based Virtual Screening and Bioassays 148
App maturation and intracellular localization are controlled by a specific inhibitor of 37/67 kda laminin-1 receptor in neuronal cells 146
Discovery Of Novel Peroxisome Proliferator-Activated Receptor γ (PPARγ) Scaffolds With Partial Agonist Binding Properties By Integrated In Silico/In Vitro Work Flow 142
Ligand-based chemoinformatic discovery of a novel small molecule inhibitor targeting CDC25 dual specificity phosphatases and displaying in vitro efficacy against melanoma cells 142
Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines 142
A compound-based proteomic approach discloses 15-ketoatractyligenin methyl ester as a new PPARγ partial agonist with anti-proliferative ability 139
Novel Reversible Inhibitors of Xanthine Oxidase Targeting the Active Site of the Enzyme 135
SARS-CoV-2 Entry Inhibitors: Small Molecules and Peptides Targeting Virus or Host Cells 134
Synthesis and in vitro cytotoxicity of benzoxazole‐based PPARα/γ antagonists in colorectal cancer cell lines 128
Enhancing De Novo Drug Design across Multiple Therapeutic Targets with CVAE Generative Models 125
Development of Novel Selective Peptidomimetics Containing a Boronic Acid Moiety, Targeting the 20S Proteasome as Anticancer Agents 123
In Silico Identification of Novel Inhibitors Targeting the Homodimeric Interface of Superoxide Dismutase from the Dental Pathogen Streptococcus mutans 122
The antiproliferative and proapoptotic effects of cladosporols A and B are related to their different binding mode as PPARγ ligands 122
Characterization of novel inhibitors of CDC25 phosphatases: biochemical and biological analysis 122
Identification of selective 5-LOX and FLAP inhibitors as novel anti-inflammatory agents by ligand-based virtual screening 116
Antitumor agents 7. Synthesis, antiproliferative activity and molecular modeling of new L-lysine-conjugated pyridophenoxazinones as potent DNA-binding ligands and topoisomerase IIα inhibitors 116
Identification of a new series of amides as non-covalent proteasome inhibitors 114
Small Molecule Drugs And Targeted Therapy For Melanoma: Current Strategies And Future Directions 113
Methyl-Transferase-Like Protein 16 (METTL16): The Intriguing Journey of a Key Epitranscriptomic Player Becoming an Emerging Biological Target 112
Development of novel amides as noncovalent inhibitors of immunoproteasomes 109
Sulfonimide and amide derivatives as novel PPARα antagonists: Synthesis, antiproliferative activity, and docking studies 109
Targeting SARS-CoV-2 Proteases and Polymerase for COVID-19 Treatment: State of the Art and Future Opportunities 107
Easy access to α-ketoamides as SARS-CoV-2 and MERS Mpro inhibitors via the PADAM oxidation route 106
Exploring structural relationships between bioactive and commercial chemical space and developing target hypotheses for compound acquisition 104
Chiral phenoxyacetic acid analogues inhibit colon cancer cell proliferation acting as PPARγ partial agonists 103
A chemical modification of a peroxisome proliferator-activated receptor pan agonist produced a shift to a new dual alpha/gamma partial agonist endowed with mitochondrial pyruvate carrier inhibition and antidiabetic properties 102
Deep generative models in the quest for anticancer drugs: ways forward 102
Novel inhibitors of signal transducer and activator of transcription 3 signaling pathway: an update on the recent patent literature 102
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity 102
“DompeKeys”: a set of novel substructure-based descriptors for efficient chemical space mapping, development and structural interpretation of machine learning models, and indexing of large databases 100
Altered Local Interactions and Long-Range Communications in UK Variant (B.1.1.7) Spike Glycoprotein 98
Selective PPARγ modulators for Type 2 diabetes treatment: How far have we come and what does the future hold? 96
In silico methods to address polypharmacology: Current status, applications and future perspectives 92
Impairment of Nucleolin Activity and Phosphorylation by a Trachylobane Diterpene from Psiadia punctulata in Cancer Cells 92
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome 91
Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors 89
“Molecular Anatomy”: a new multi-dimensional hierarchical scaffold analysis tool 89
Exploring the Role of N(6)-Substituents in Potent Dual Acting 5'-C-Ethyltetrazolyladenosine Derivatives: Synthesis, Binding, Functional Assays, and Antinociceptive Effects in Mice 87
New avenues in artificial-intelligence-assisted drug discovery 86
Computational studies of SARS-CoV-2 3clpro: Insights from md simulations 84
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition 76
In Silico Drug Design and Discovery: Big Data for Small Molecule Design 73
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode 73
Binding mode exploration of b1 receptor antagonists’ by the use of molecular dynamics and docking simulation—how different target engagement can determine different biological effects 73
A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity 69
A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects 67
A sulfonimide derivative of bezafibrate as a dual inhibitor of cyclooxygenase-2 and PPARα 66
Identification of the First PPARα/γ Dual Agonist Able to Bind to Canonical and Alternate Sites of PPARγ and to Inhibit its Cdk5-Mediated Phosphorylation 65
Challenging triple negative breast cancer through HDAC6 selective inhibition: Novel cap-group identification, structure-activity relationships, computational and biological studies 64
Recent advances in developing PCSK9 inhibitors for lipid-lowering therapy 63
Editorial: Recent trends in anti-cancer drug discovery by in silico methods 57
Fine-tuning the combination of novel spirocyclic capping moieties and heterocyclic zinc binding groups for selective HDAC6 inhibition: design, synthesis, kinetic and biological studies 44
Evaluation of molecular mechanisms of (Z)-3-(pentadec-10′-enyl)-catechol (litreol) and synthetic derivatives as inhibitors of human leukotriene biosynthesis 37
Artificial intelligence in the development of small nucleic acid therapeutics: toward smarter and safer medicines 33
Structural and functional characterization of chemically modified antisense oligonucleotides targeting miR-214-3p in endothelial cells 32
null 26
Artificial Intelligence in De Novo Drug Design 24
Artificial Intelligence in Ligand-Based Drug Design 20
AI-Driven Discovery of microRNA Targets for Disease Therapy and Drug Development 20
Artificial Intelligence in Structure-Based Drug Design 19
ProfhEX: Empowering Early Drug Discovery with Machine Learning-Based Target Profiling and Liability Prediction 19
In Silico Drug Design and Discovery: Big Data for Small Molecule Design—2nd Edition 8
Totale 6.215
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Categoria #
all - tutte 20.331
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 20.331
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022252 0 0 6 8 18 11 1 4 53 3 51 97
2022/2023285 36 15 17 23 15 30 7 27 40 33 22 20
2023/2024282 18 23 27 22 6 19 8 70 3 4 61 21
2024/20251.533 65 85 14 24 51 93 199 112 62 120 562 146
2025/20263.205 295 241 401 270 462 146 365 177 371 219 102 156
2026/2027300 67 142 91 0 0 0 0 0 0 0 0 0
Totale 6.215