IRIS
COSIMELLI, BARBARA
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
AS - Asia 2.251
EU - Europa 2.166
NA - Nord America 2.120
SA - Sud America 360
AF - Africa 36
Continente sconosciuto - Info sul continente non disponibili 3
OC - Oceania 2
Totale 6.938
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 2.037
SG - Singapore 1.352
RU - Federazione Russa 878
CN - Cina 428
IT - Italia 325
BR - Brasile 313
UA - Ucraina 241
HK - Hong Kong 228
NL - Olanda 208
DE - Germania 127
VN - Vietnam 98
SE - Svezia 94
FI - Finlandia 93
IE - Irlanda 71
GB - Regno Unito 70
CA - Canada 52
IN - India 29
MX - Messico 26
TR - Turchia 22
FR - Francia 14
AR - Argentina 13
BD - Bangladesh 13
ID - Indonesia 13
PL - Polonia 13
IQ - Iraq 9
ZA - Sudafrica 9
CI - Costa d'Avorio 8
ES - Italia 8
JP - Giappone 7
TH - Thailandia 7
UZ - Uzbekistan 7
CO - Colombia 6
EC - Ecuador 6
VE - Venezuela 6
KR - Corea 5
PE - Perù 5
BE - Belgio 4
CL - Cile 4
LB - Libano 4
MA - Marocco 4
PK - Pakistan 4
PT - Portogallo 4
AZ - Azerbaigian 3
BO - Bolivia 3
IL - Israele 3
KE - Kenya 3
NP - Nepal 3
PS - Palestinian Territory 3
UY - Uruguay 3
AO - Angola 2
AT - Austria 2
GR - Grecia 2
KZ - Kazakistan 2
LT - Lituania 2
MY - Malesia 2
NE - Niger 2
OM - Oman 2
SA - Arabia Saudita 2
AE - Emirati Arabi Uniti 1
AL - Albania 1
BB - Barbados 1
BF - Burkina Faso 1
BY - Bielorussia 1
CH - Svizzera 1
CW - ???statistics.table.value.countryCode.CW??? 1
CZ - Repubblica Ceca 1
DK - Danimarca 1
EG - Egitto 1
EU - Europa 1
GE - Georgia 1
HR - Croazia 1
JO - Giordania 1
KH - Cambogia 1
LY - Libia 1
MD - Moldavia 1
MW - Malawi 1
NA - Namibia 1
NI - Nicaragua 1
NZ - Nuova Zelanda 1
PA - Panama 1
PH - Filippine 1
PY - Paraguay 1
RO - Romania 1
RS - Serbia 1
SD - Sudan 1
SK - Slovacchia (Repubblica Slovacca) 1
SN - Senegal 1
TN - Tunisia 1
TT - Trinidad e Tobago 1
VC - Saint Vincent e Grenadine 1
WS - Samoa 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 6.938
Salva come PNG Salva come JPEG
Città #
Singapore 645
Chandler 267
Jacksonville 252
Hong Kong 223
Amsterdam 200
Moscow 199
Beijing 117
Ashburn 91
Princeton 91
Naples 90
Boston 84
Millbury 79
Santa Clara 74
Nanjing 66
Buffalo 51
Wilmington 50
Los Angeles 48
Napoli 48
Dallas 46
Ho Chi Minh City 32
Boardman 31
Ottawa 30
São Paulo 25
Houston 23
The Dalles 22
Nanchang 20
Hebei 19
Redondo Beach 19
Shenyang 18
Jiaxing 17
Mexico City 17
Des Moines 16
New York 16
Seattle 16
Hefei 15
Redwood City 14
Woodbridge 14
Ann Arbor 13
Chicago 13
Warsaw 13
Kronberg 12
Tianjin 11
Hanoi 10
Orange 10
Brooklyn 9
London 9
Norwalk 9
Rio de Janeiro 9
Belo Horizonte 8
Denver 8
Dong Ket 8
Frankfurt am Main 8
Changsha 7
Kunming 7
Montreal 7
Porto Alegre 7
San Francisco 7
Tashkent 7
Ankara 6
Como 6
Jinan 6
Phra Nakhon Si Ayutthaya 6
Rome 6
Shenzhen 6
Tokyo 6
Atlanta 5
Biên Hòa 5
Bologna 5
Chennai 5
Dhaka 5
Dublin 5
Istanbul 5
Johannesburg 5
Marigliano 5
Milan 5
Munich 5
Seoul 5
Toronto 5
Abidjan 4
Betim 4
Brasília 4
Changchun 4
Charlotte 4
Da Nang 4
Dronten 4
Goiânia 4
Haiphong 4
Jakarta 4
Lima 4
Poplar 4
Redmond 4
Shanghai 4
Stockholm 4
Thrissur 4
Augusta 3
Baghdad 3
Baku 3
Bogotá 3
Brussels 3
Campo Largo 3
Totale 3.466
Salva come PNG Salva come JPEG
Nome #
4-amino-6-alkyloxy-2-alkylthiopyrimidine derivatives as novel non-nucleoside agonists for the adenosine A1 receptor 184
Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A1 adenosine receptor antagonists 140
Studies on enantioselectivity of chiral 4-acetylamino-6-alkyloxy-2-alkylthiopyrimidines acting as antagonists of the human A3 adenosine receptor 122
3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A2B adenosine receptor antagonists 108
New Fluorescent 2-Phenylindolglyoxylamide Derivatives as Probes Targeting the Peripheral-Type Benzodiazepine Receptor: Design, Synthesis and Biological Evaluation. 106
A New Entry to Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidine Derivatives. 102
Anxiolytic-like Effects of N,N-Dialkyl-2-phenylindol-3-ylglyoxylamides by Modulation of Translocator Protein Promoting Neurosteroid Biosynthesis. 100
Zinc phthalocyanines and corresponding conjugates, their preparation and use in photodynamic therapy and as diagnostic agents. 99
Identification of novel indole derivatives acting as inhibitors of the Keap1–Nrf2 interaction 99
Substituent effect on the electrochemical behaviour of some ortho-substituted (aryl)(2-nitrobenzo[b]thiophen-3-yl)amines. A combined experimental and computational study. 98
Synthesis, Citotoxicity and Apoptosis Induction in Human Tumor Cells by Geiparvarin Analogues 98
TSPO-ligands prevent oxidative damage and inflammatory response in C6 glioma cells by neurosteroid synthesis 96
1H and 13C NMR Study of the Pyrazolo[1,5-a]pyrimidine System. 94
2-(Benzimidazol-2-yl)quinoxalines: a Movel Class of Selective Antagonists at Human A(1) and A(3) Adenosine Receptors Designed by 3D Database Searching. 94
2-Phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one derivatives as a new class of adenosine receptor antagonists 92
5-Amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: A Versatile Scaffold to Obtain Potent and Selective A3 Adenosine Receptor Antagonists. 91
A New Class of Selective Myocardial Calcium Channel Modulators. 2. The Role of the Acetal Chain in Oxadiazol-3-one Derivatives 89
Determination of the Absolute Configuration of a Chiral Oxadiazol-3-one Calcium Channel Blocker, Resolved by Using Chiral Chromatography, via Concerted Density Functional Theory Calculations of Its Vibrational Circular Dichroism, Electronic Circular Dichroism, and Optical Rotation. 88
Synthesis and biological evaluation of imidazo[1,2-a]pyrimidines and imidazo[1,2-a]pyridines as new inhibitors of the Wnt/β-catenin signaling 88
Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides 88
Diltiazem Analogues: The Last Ten Years on Structure Activity Relationships. 87
Allosteric Modulators of Human A2B Adenosine Receptor 86
New results on the reactivity of 5,6-diamino-4-hydroxy-2-mercaptopyrimidine 85
Calcium Channel Antagonists Discovered by a Multidisciplinary Approach. 84
8H-Pyrazolo[5',1':2,3]pyrimido[5,4-d][1,2]diazepine: A New Tricyclic System. 84
Refinement of the Benzodiazepine Receptor Site Topology by Structure-Activity Relationships of New N-(Heteroarylmethyl)indol-3-ylglyoxylamides. 83
Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation 83
3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A2B adenosine receptor antagonists 83
Novel N-Substituted Indol-3-ylglyoxylamides Probing the LDi and L1/L2 Lipophilic Regions of the Benzodiazepine Receptor Site in Search for Subtype-Selective Ligands. 82
Allosteric modulation of A2B adenosine receptors potentiate the effects of orthosteric receptor agonists to promote mesenchymal stem cell differentiation to osteoblasts 80
Cardiovascular characterization of [1,4]thiazino[3,4-c][1,2,4]oxadiazol-3-one-derivatives: selective myocardial calcium channel modulators. 79
A New Synthetic Route to 2,2’:5’,2”-Terthiophene-5-derivatives to Conjugate with Proteins and Monoclonal Antibodies. 79
Alkali-metal Complexes with Neutral Molecular Receptors containing Nitrogen Donor Atoms: a Crystallographic and Multinuclear Magnetic Resonance Study. 79
A convenient synthesis of psoralens. 79
A New Convenient Route to 2-Oxoethoxycoumarins: Key Intermediates in the Synthesis of Natural Products. 79
On the Nitration of 5-Phenyl- and 3-Methyl-5-phenylisoxazole. 78
A novel approach to the evaluation of the importance of steric and electronic effects in SNAr reactions: a computational, thermodynamic, 1H and 13C NMR study of “Meisenheimer-type” adducts in the benzo[b]thiophene series 77
Studies on Azole-to-Azole Interconversion. An Interesting Case of Absence of “Primary Steric Effect” in the Ring-degenerate Equilibration between ortho-Substituted 3-Aroylamino-5-methyl-1,2,4-oxadiazoles and 3-Acetylamino-5-aryl-1,2,4-oxadiazoles in Methanol. 76
Studies in organic mass spectrometry. Part 24 Electron ionization mass spectra of some aryl(2-nitrobenzo[b]thiophen-3-yl)amines. 76
Identification of anxiolytic/non sedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the GABAA alfa2 benzodiazepine receptor 75
Chemistry of Substituted Pyrazolo[1,5-a]pyrimidines. Part 4. A Structural Correction of a Series of Pyrazolo[5',1':2,3]pyrimido[5,4-d][1,3]diazepines on the Basis of NMR Spectroscopy and X-Ray Diffraction Analysis. 74
A1 adenosine receptor antagonists, 3-aryl[1,2,4]triazino[4,3-a]benzimidazol-4-(10H)-ones (ATBIs) and N-alkyl and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs): Different recognition of bovine and human binding sites 74
Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism 74
Natural and Synthetic Geiparvarins Are Strong and Selective MAO-B Inhibitors. Synthesis and SAR Studies. 72
New geiparvarin analogues from 7-(2-oxoethoxy)coumarins as efficient in vitro antitumoral agents. 71
Ring opening of 2-substituted 4-nitrothiophenes with pyrrolidine. Access to new functionalized nitro-unsaturated building blocks. 71
Mononuclear Heterocyclic Rearrangements. Part 16. Kinetic Study of the Rearrangement of Some ortho-Substituted Z-Phenylhydrazones of 3-Benzoyl-5-phenyl-1,2,4-oxadiazole into 2-Aryl-4-benzoylamino-5-phenyl-1,2,3-triazoles in Dioxane-Water and in Benzene. 71
Synthesis and antimycotic activity of new unsymmetrical substituted zinc phthalocyanines. 70
Carbon-13 NMR Studies on Azolopyridines. 3-The Isothiazolopyridine Systems. 70
On the reaction of 3-bromo-2-nitrobenzo[b]thiophene with some ortho-substituted anilines: an analysis of the products of reaction and of their NMR and MS properties 69
Substituent effect on the redox potential of some substituted (aryl)(2-nitrobenzo[b]thiophen-3-yl)amines. 69
Ring-ring Interconversions. Part 3. On the effect of the substituents on the thiazole moiety in the ring-opening/ring-closing reactions of nitrosoimidazo[2,1-b][1,3]thiazoles with hydrochloric acid. 69
Enantiomeric 4-Acylamino-6-alkyloxy-2 Alkylthiopyrimidines As Potential A3 Adenosine Receptor Antagonists: HPLC Chiral Resolution and Absolute Configuration Assignment by a Full Set of Chiroptical Spectroscopy 69
Ring-ring interconversions. Part 2. Effect of the Substituent on the Rearrangement of 6-Aryl-3-methyl-5-nitrosoimidazo[2,1-b][1,3]thiazoles into 8-Aryl-8-hydroxy-5-methyl-8H-[1,4]thiazino[3,4-c][1,2,4]oxadiazol-3-ones. A Novel Class of Potential Antitumor Agents. 68
On the Synthesis and Reactivity of the Z-2,4-Dinitrophenylhydrazone of 5-Amino-3-benzoyl-1,2,4-oxadiazole. 67
Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidine: A New Heterocyclic Ring System. 67
Derivatives of 4-Amino-6-hydroxy-2-mercaptopyrimidine as Novel, Potent, and Selective A3 Adenosine Receptor Antagonists 67
Chemistry of Substituted Pyrazolo[1,5-a]pyrimidines. Part 3. A Structural Correc¬tion of Pyrazolo[1,5-a][1,3]diazepine Derivative on the Basis of 13C NMR Spectroscopy. 66
From the central benzodiazepine receptor to the adenosine receptors exploiting the 3-diketoindole moiety 66
Regioselective Synthesis of 4-Acetyl- and 5-Acetyl-3-methylisoxazole: their Conversion into Silyl- and Methyl Enol Ethers. 65
The First Kinetic Evidence for Acid Catalysis in a Monocyclic Rearrangement of Heterocycles: Conversion of the Z-Phenylhydrazone of 5-Amino-3-benzoyl-1,2,4-oxadiazole into N,5-Diphenyl-2H-1,2,3-triazol-4-ylurea 65
High Affinity Central Benzodiazepine Receptor Ligands: Synthesis and Biological Evaluation of a Series of Phenyltriazolobenzotriazindione Derivatives (PTBTs) 65
Derivatives of benzimidazol-2-ylquinoline and benzimidazol-2-ylisoquinoline as selective A1 adenosine receptor antagonists with stimulant activity on human colon motility 65
New 5-(2-ethenylsubstituted)-3(2H)-furanones with in vitro antiproliferative activity 64
On the Reactivity of 3-Bromo-2-nitrobenzo[b]thiophene with Nucleophiles: Elucidation of the Base-Catalyzed Mechanism with Rearrangement. 64
Ring-ring Interconversions of Nitrosoimidazoles. The Effect of Some Condensed Six-membered Rings on the Reactivity. 64
ABCB1 Structural Models, Molecular Docking, and Synthesis of New Oxadiazolothiazin-3-one Inhibitors 64
Complete 1H (600 MHz) and 13C NMR Spectral Assignment of 3,4-bis[(3,4-Dimethoxyphenyl)methyl]dihydro-(3R-trans)-2(3H)-furanone (Matairesinol Dimethyl Ether), a Naturally Occurring Dibenzylbutyrolactone Lignan. 63
The P-glycoprotein inhibitor diltiazem-like 8-(4-chlorophenyl)-5-methyl-8-[(2Z)-pent-2-en-1-yloxy]-8H-[1,2,4]oxadiazolo[3,4-c][1,4]thiazin-3-one inhibits esterase activity and H3 histone acetylation 63
Unambiguous Structure Determination of Some Pyrazolo[1,5-a]pyrimidine Derivatives by Multinuclear NMR Spectroscopy. 62
From the Pharmacophore to the Homology Model of the Benzodiazepine Receptor: The Indolyglyoxylamides Affair. 62
Modulation of A2B adenosine receptor by 1-Benzyl-3-ketoindole derivatives 62
Chemistry of substituted pyrazolo[1,5-a]pyrimidines. Part 5. 7-Oxo-6-[pyrazol-3’(5’)-yl]-4,7-dihydropyrazolo[1,5-a]pyrimidines from 6-ethoxycarbonyl-7-(2-dimethylaminovinyl)-pyrazolo[1,5-a]pyrimidines: elucidation of the reaction mechanism through NMR spectroscopy and X-Ray diffraction analysis. 61
Determination of the absolute configuration of the enantiomers of an oxadiazol-3-one calcium channel blocker, resolved by chiral HPLC, via concerted use of three chiroptical spectroscopies 61
Ring-ring interconversion: the rearrangement of 6-(4-chlorophenyl)-3-methyl-5-nitrosoimidazo[2,1-b][1,3]thiazole into 8-(4-chlorophenyl)-8-hydroxy-5-methyl-8H-[1,4]thiazino[3,4-c][1,2,4]oxadiazol-3-one. Elucidation of the reaction product through spectroscopic and X-ray crystal structure analysis. 59
Novel Irreversible Fluorescent Probes Targeting the 18kDa Translocator Protein: Synthesis and Biological Characterization. 59
On the reactivity of nitrosoimidazoles with acids (the Cusmano-Ruccia reaction): a continuous source of new ring-into-ring interconversion 58
Synthesis and L-type calcium channel blocking activity of new chiral oxadiazolothiazinones 57
Novel fluorescent triazinobenzimidazole derivatives as probes for labelling human A1 and A2B adenosine receptor subtypes 56
L-Type calcium channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives 55
Absolute configuration and biological profile of two thiazinooxadiazol-3-ones with L-type calcium channel activity: a study of the structural effects 55
Synthesis and biological evaluation on human glioblastoma cells of novel pyrazolo[3,4-d]pyrimidine adenosine A(3) receptor antagonists 55
Playing with Opening and Closing of Heterocycles: Using the Cusmano-Ruccia Reaction to Develop a Novel Class of Oxadiazolothiazinones, Active as Calcium Channel Modulators and P-Glycoprotein Inhibitors 54
p53 Functional Inhibitors Behaving Like Pifithrin-? Counteract the Alzheimer Peptide Non-?-amyloid Component Effects in Human SH-SY5Y Cells 52
Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators 52
An Unexpected Pathway to Enantiomerization of Hemithioketals in Toluene Involving a Dimeric Transition State: A Combined Experimental and Computational Study 52
Discovery of novel and cardioselective diltiazem-like calcium channel blockers via virtual screening. 51
ortho-Substituted (aryl)(3-nitrobenzo[b]thiophen-2-yl)amines: study of the electrochemical behavior 51
First example of Diels-Alder reaction of 4-(1-ethenylsubstituted)-3-methylisoxazoles with acetylenedicarboxylate 50
Preliminary Finding on a New Calcium Channel Entry Blocker Chemotype: 5,6-Diamino-4-hydroxy-2-mercaptopyrimidine Derivatives 50
The Boulton–Katritzky Reaction: A Kinetic Study of the Effect of 5-Nitrogen Substituents on the Rearrangement of Some (Z)-Phenylhydrazones of 3-Benzoyl-1,2,4-oxadiazoles 50
Inhibition of MDR1 activity in vitro by a novel class of diltiazem analogues: towards new candidates 49
Selective and Practical Oxidation of Sulfides to Diastereopure Sulfoxides: A Combined Experimental and Computational Investigation 48
Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein 47
Totale 7.024
Salva come PNG Salva come JPEG
Categoria #
all - tutte 26.753
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 26.753
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021290 0 0 0 0 0 83 59 1 59 11 58 19
2021/2022422 18 1 3 3 3 6 5 17 78 3 78 207
2022/2023743 107 64 9 72 73 50 4 48 81 193 29 13
2023/2024356 27 62 105 26 12 8 1 29 1 3 44 38
2024/20252.121 124 167 6 4 31 71 269 142 210 179 720 198
2025/20261.929 438 213 304 271 598 105 0 0 0 0 0 0
Totale 7.024