COSIMELLI, BARBARA
 Distribuzione geografica
Continente #
NA - Nord America 1.392
EU - Europa 1.159
AS - Asia 247
AF - Africa 5
SA - Sud America 3
Continente sconosciuto - Info sul continente non disponibili 1
OC - Oceania 1
Totale 2.808
Nazione #
US - Stati Uniti d'America 1.357
IT - Italia 299
UA - Ucraina 233
CN - Cina 217
NL - Olanda 204
DE - Germania 111
FI - Finlandia 90
SE - Svezia 90
IE - Irlanda 69
GB - Regno Unito 37
CA - Canada 34
IN - India 10
TR - Turchia 10
RU - Federazione Russa 9
VN - Vietnam 8
FR - Francia 7
CI - Costa d'Avorio 4
PT - Portogallo 3
BE - Belgio 2
CL - Cile 2
GR - Grecia 2
SG - Singapore 2
BR - Brasile 1
ES - Italia 1
EU - Europa 1
HR - Croazia 1
MX - Messico 1
NZ - Nuova Zelanda 1
SK - Slovacchia (Repubblica Slovacca) 1
ZA - Sudafrica 1
Totale 2.808
Città #
Chandler 267
Jacksonville 251
Amsterdam 198
Princeton 91
Naples 85
Millbury 79
Boston 73
Nanjing 66
Napoli 48
Wilmington 48
Beijing 38
Boardman 31
Ottawa 29
Nanchang 20
Hebei 19
Jiaxing 17
Des Moines 16
Houston 16
Shenyang 16
Redwood City 14
Woodbridge 14
Ann Arbor 13
Kronberg 12
Ashburn 10
Orange 10
Tianjin 10
Norwalk 9
Dong Ket 8
Seattle 7
Como 6
Kunming 6
Bologna 5
Changsha 5
Jinan 5
Marigliano 5
Changchun 4
Dronten 4
Redmond 4
Rome 4
Thrissur 4
Dublin 3
Falls Church 3
Hangzhou 3
Istanbul 3
Lawrence 3
Shanghai 3
Shenzhen 3
Torre Del Greco 3
Angri 2
Ardore 2
Athens 2
Augusta 2
Battipaglia 2
Brussels 2
Casoria 2
Cava De' Tirreni 2
Dortmund 2
Edmonton 2
Frankfurt am Main 2
La Canada Flintridge 2
London 2
Marina di Montemarciano 2
Mugnano Di Napoli 2
Pune 2
San Francisco 2
Serra 2
Toronto 2
Würzburg 2
Atlanta 1
Berlin 1
Bhopal 1
Brescia 1
Buffalo 1
Campobasso 1
Capua 1
Castel Volturno 1
Castenaso 1
Castrop-rauxel 1
Centro 1
Cerro Maggiore 1
Chicago 1
Dearborn 1
Duncan 1
Edinburgh 1
Forino 1
Fremont 1
Gurgaon 1
Helsinki 1
Indiana 1
Johannesburg 1
Leawood 1
Magdeburg 1
Mexico City 1
Milan 1
Montecorice 1
Muenster 1
Nocera Inferiore 1
Nürnberg 1
Pesaro 1
Piana 1
Totale 1.663
Nome #
4-amino-6-alkyloxy-2-alkylthiopyrimidine derivatives as novel non-nucleoside agonists for the adenosine A1 receptor 78
Studies on enantioselectivity of chiral 4-acetylamino-6-alkyloxy-2-alkylthiopyrimidines acting as antagonists of the human A3 adenosine receptor 78
Synthesis, Citotoxicity and Apoptosis Induction in Human Tumor Cells by Geiparvarin Analogues 58
Substituent effect on the electrochemical behaviour of some ortho-substituted (aryl)(2-nitrobenzo[b]thiophen-3-yl)amines. A combined experimental and computational study. 55
Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A1 adenosine receptor antagonists 55
2-(Benzimidazol-2-yl)quinoxalines: a Movel Class of Selective Antagonists at Human A(1) and A(3) Adenosine Receptors Designed by 3D Database Searching. 55
Determination of the Absolute Configuration of a Chiral Oxadiazol-3-one Calcium Channel Blocker, Resolved by Using Chiral Chromatography, via Concerted Density Functional Theory Calculations of Its Vibrational Circular Dichroism, Electronic Circular Dichroism, and Optical Rotation. 54
New Fluorescent 2-Phenylindolglyoxylamide Derivatives as Probes Targeting the Peripheral-Type Benzodiazepine Receptor: Design, Synthesis and Biological Evaluation. 52
Calcium Channel Antagonists Discovered by a Multidisciplinary Approach. 51
Allosteric modulation of A2B adenosine receptors potentiate the effects of orthosteric receptor agonists to promote mesenchymal stem cell differentiation to osteoblasts 50
Zinc phthalocyanines and corresponding conjugates, their preparation and use in photodynamic therapy and as diagnostic agents. 50
New results on the reactivity of 5,6-diamino-4-hydroxy-2-mercaptopyrimidine 48
A New Entry to Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidine Derivatives. 47
3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A2B adenosine receptor antagonists 47
Diltiazem Analogues: The Last Ten Years on Structure Activity Relationships. 46
A New Class of Selective Myocardial Calcium Channel Modulators. 2. The Role of the Acetal Chain in Oxadiazol-3-one Derivatives 45
3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A2B adenosine receptor antagonists 44
A1 adenosine receptor antagonists, 3-aryl[1,2,4]triazino[4,3-a]benzimidazol-4-(10H)-ones (ATBIs) and N-alkyl and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs): Different recognition of bovine and human binding sites 43
5-Amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: A Versatile Scaffold to Obtain Potent and Selective A3 Adenosine Receptor Antagonists. 43
Identification of novel indole derivatives acting as inhibitors of the Keap1–Nrf2 interaction 42
1H and 13C NMR Study of the Pyrazolo[1,5-a]pyrimidine System. 41
A New Convenient Route to 2-Oxoethoxycoumarins: Key Intermediates in the Synthesis of Natural Products. 40
A novel approach to the evaluation of the importance of steric and electronic effects in SNAr reactions: a computational, thermodynamic, 1H and 13C NMR study of “Meisenheimer-type” adducts in the benzo[b]thiophene series 40
Synthesis and biological evaluation of imidazo[1,2-a]pyrimidines and imidazo[1,2-a]pyridines as new inhibitors of the Wnt/β-catenin signaling 40
8H-Pyrazolo[5',1':2,3]pyrimido[5,4-d][1,2]diazepine: A New Tricyclic System. 38
Allosteric Modulators of Human A2B Adenosine Receptor 37
Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism 37
Alkali-metal Complexes with Neutral Molecular Receptors containing Nitrogen Donor Atoms: a Crystallographic and Multinuclear Magnetic Resonance Study. 35
TSPO-ligands prevent oxidative damage and inflammatory response in C6 glioma cells by neurosteroid synthesis 35
Anxiolytic-like Effects of N,N-Dialkyl-2-phenylindol-3-ylglyoxylamides by Modulation of Translocator Protein Promoting Neurosteroid Biosynthesis. 34
Refinement of the Benzodiazepine Receptor Site Topology by Structure-Activity Relationships of New N-(Heteroarylmethyl)indol-3-ylglyoxylamides. 33
ABCB1 Structural Models, Molecular Docking, and Synthesis of New Oxadiazolothiazin-3-one Inhibitors 33
On the Synthesis and Reactivity of the Z-2,4-Dinitrophenylhydrazone of 5-Amino-3-benzoyl-1,2,4-oxadiazole. 32
2-Phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one derivatives as a new class of adenosine receptor antagonists 32
Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides 32
A New Synthetic Route to 2,2’:5’,2”-Terthiophene-5-derivatives to Conjugate with Proteins and Monoclonal Antibodies. 31
A convenient synthesis of psoralens. 31
On the Reactivity of 3-Bromo-2-nitrobenzo[b]thiophene with Nucleophiles: Elucidation of the Base-Catalyzed Mechanism with Rearrangement. 30
Mononuclear Heterocyclic Rearrangements. Part 16. Kinetic Study of the Rearrangement of Some ortho-Substituted Z-Phenylhydrazones of 3-Benzoyl-5-phenyl-1,2,4-oxadiazole into 2-Aryl-4-benzoylamino-5-phenyl-1,2,3-triazoles in Dioxane-Water and in Benzene. 30
On the Nitration of 5-Phenyl- and 3-Methyl-5-phenylisoxazole. 30
Cardiovascular characterization of [1,4]thiazino[3,4-c][1,2,4]oxadiazol-3-one-derivatives: selective myocardial calcium channel modulators. 29
Studies in organic mass spectrometry. Part 24 Electron ionization mass spectra of some aryl(2-nitrobenzo[b]thiophen-3-yl)amines. 29
Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidine: A New Heterocyclic Ring System. 29
High Affinity Central Benzodiazepine Receptor Ligands: Synthesis and Biological Evaluation of a Series of Phenyltriazolobenzotriazindione Derivatives (PTBTs) 29
Enantiomeric 4-Acylamino-6-alkyloxy-2 Alkylthiopyrimidines As Potential A3 Adenosine Receptor Antagonists: HPLC Chiral Resolution and Absolute Configuration Assignment by a Full Set of Chiroptical Spectroscopy 29
New geiparvarin analogues from 7-(2-oxoethoxy)coumarins as efficient in vitro antitumoral agents. 28
Studies on Azole-to-Azole Interconversion. An Interesting Case of Absence of “Primary Steric Effect” in the Ring-degenerate Equilibration between ortho-Substituted 3-Aroylamino-5-methyl-1,2,4-oxadiazoles and 3-Acetylamino-5-aryl-1,2,4-oxadiazoles in Methanol. 28
Ring-ring Interconversions. Part 3. On the effect of the substituents on the thiazole moiety in the ring-opening/ring-closing reactions of nitrosoimidazo[2,1-b][1,3]thiazoles with hydrochloric acid. 28
Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation 28
Natural and Synthetic Geiparvarins Are Strong and Selective MAO-B Inhibitors. Synthesis and SAR Studies. 27
Substituent effect on the redox potential of some substituted (aryl)(2-nitrobenzo[b]thiophen-3-yl)amines. 27
The P-glycoprotein inhibitor diltiazem-like 8-(4-chlorophenyl)-5-methyl-8-[(2Z)-pent-2-en-1-yloxy]-8H-[1,2,4]oxadiazolo[3,4-c][1,4]thiazin-3-one inhibits esterase activity and H3 histone acetylation 27
On the reaction of 3-bromo-2-nitrobenzo[b]thiophene with some ortho-substituted anilines: an analysis of the products of reaction and of their NMR and MS properties 26
Chemistry of substituted pyrazolo[1,5-a]pyrimidines. Part 5. 7-Oxo-6-[pyrazol-3’(5’)-yl]-4,7-dihydropyrazolo[1,5-a]pyrimidines from 6-ethoxycarbonyl-7-(2-dimethylaminovinyl)-pyrazolo[1,5-a]pyrimidines: elucidation of the reaction mechanism through NMR spectroscopy and X-Ray diffraction analysis. 26
Unambiguous Structure Determination of Some Pyrazolo[1,5-a]pyrimidine Derivatives by Multinuclear NMR Spectroscopy. 26
Ring opening of 2-substituted 4-nitrothiophenes with pyrrolidine. Access to new functionalized nitro-unsaturated building blocks. 25
Carbon-13 NMR Studies on Azolopyridines. 3-The Isothiazolopyridine Systems. 25
Novel fluorescent triazinobenzimidazole derivatives as probes for labelling human A1 and A2B adenosine receptor subtypes 25
Ring-ring Interconversions of Nitrosoimidazoles. The Effect of Some Condensed Six-membered Rings on the Reactivity. 24
Ring-ring interconversions. Part 2. Effect of the Substituent on the Rearrangement of 6-Aryl-3-methyl-5-nitrosoimidazo[2,1-b][1,3]thiazoles into 8-Aryl-8-hydroxy-5-methyl-8H-[1,4]thiazino[3,4-c][1,2,4]oxadiazol-3-ones. A Novel Class of Potential Antitumor Agents. 24
Regioselective Synthesis of 4-Acetyl- and 5-Acetyl-3-methylisoxazole: their Conversion into Silyl- and Methyl Enol Ethers. 24
The First Kinetic Evidence for Acid Catalysis in a Monocyclic Rearrangement of Heterocycles: Conversion of the Z-Phenylhydrazone of 5-Amino-3-benzoyl-1,2,4-oxadiazole into N,5-Diphenyl-2H-1,2,3-triazol-4-ylurea 24
Novel Irreversible Fluorescent Probes Targeting the 18kDa Translocator Protein: Synthesis and Biological Characterization. 24
Absolute configuration and biological profile of two thiazinooxadiazol-3-ones with L-type calcium channel activity: a study of the structural effects 24
Identification of anxiolytic/non sedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the GABAA alfa2 benzodiazepine receptor 23
From the Pharmacophore to the Homology Model of the Benzodiazepine Receptor: The Indolyglyoxylamides Affair. 23
p53 Functional Inhibitors Behaving Like Pifithrin-? Counteract the Alzheimer Peptide Non-?-amyloid Component Effects in Human SH-SY5Y Cells 23
Synthesis and L-type calcium channel blocking activity of new chiral oxadiazolothiazinones 23
Ring-ring interconversion: the rearrangement of 6-(4-chlorophenyl)-3-methyl-5-nitrosoimidazo[2,1-b][1,3]thiazole into 8-(4-chlorophenyl)-8-hydroxy-5-methyl-8H-[1,4]thiazino[3,4-c][1,2,4]oxadiazol-3-one. Elucidation of the reaction product through spectroscopic and X-ray crystal structure analysis. 22
Chemistry of Substituted Pyrazolo[1,5-a]pyrimidines. Part 3. A Structural Correc¬tion of Pyrazolo[1,5-a][1,3]diazepine Derivative on the Basis of 13C NMR Spectroscopy. 22
New 5-(2-ethenylsubstituted)-3(2H)-furanones with in vitro antiproliferative activity 21
Chemistry of Substituted Pyrazolo[1,5-a]pyrimidines. Part 4. A Structural Correction of a Series of Pyrazolo[5',1':2,3]pyrimido[5,4-d][1,3]diazepines on the Basis of NMR Spectroscopy and X-Ray Diffraction Analysis. 21
Complete 1H (600 MHz) and 13C NMR Spectral Assignment of 3,4-bis[(3,4-Dimethoxyphenyl)methyl]dihydro-(3R-trans)-2(3H)-furanone (Matairesinol Dimethyl Ether), a Naturally Occurring Dibenzylbutyrolactone Lignan. 21
An Unexpected Pathway to Enantiomerization of Hemithioketals in Toluene Involving a Dimeric Transition State: A Combined Experimental and Computational Study 21
Derivatives of 4-Amino-6-hydroxy-2-mercaptopyrimidine as Novel, Potent, and Selective A3 Adenosine Receptor Antagonists 20
Selective and Practical Oxidation of Sulfides to Diastereopure Sulfoxides: A Combined Experimental and Computational Investigation 20
Synthesis and antimycotic activity of new unsymmetrical substituted zinc phthalocyanines. 19
On the reactivity of nitrosoimidazoles with acids (the Cusmano-Ruccia reaction): a continuous source of new ring-into-ring interconversion 19
Preliminary Finding on a New Calcium Channel Entry Blocker Chemotype: 5,6-Diamino-4-hydroxy-2-mercaptopyrimidine Derivatives 18
Modulation of A2B adenosine receptor by 1-Benzyl-3-ketoindole derivatives 17
From the central benzodiazepine receptor to the adenosine receptors exploiting the 3-diketoindole moiety 17
Discovery of novel and cardioselective diltiazem-like calcium channel blockers via virtual screening. 16
L-Type calcium channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives 16
Derivatives of benzimidazol-2-ylquinoline and benzimidazol-2-ylisoquinoline as selective A1 adenosine receptor antagonists with stimulant activity on human colon motility 16
The Boulton–Katritzky Reaction: A Kinetic Study of the Effect of 5-Nitrogen Substituents on the Rearrangement of Some (Z)-Phenylhydrazones of 3-Benzoyl-1,2,4-oxadiazoles 16
First example of Diels-Alder reaction of 4-(1-ethenylsubstituted)-3-methylisoxazoles with acetylenedicarboxylate 15
ortho-Substituted (aryl)(3-nitrobenzo[b]thiophen-2-yl)amines: study of the electrochemical behavior 15
Playing with Opening and Closing of Heterocycles: Using the Cusmano-Ruccia Reaction to Develop a Novel Class of Oxadiazolothiazinones, Active as Calcium Channel Modulators and P-Glycoprotein Inhibitors 15
Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators 14
Inhibition of MDR1 activity in vitro by a novel class of diltiazem analogues: towards new candidates 11
Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein 11
Synthesis and biological evaluation on human glioblastoma cells of novel pyrazolo[3,4-d]pyrimidine adenosine A(3) receptor antagonists 11
Determination of the absolute configuration of the enantiomers of an oxadiazol-3-one calcium channel blocker, resolved by chiral HPLC, via concerted use of three chiroptical spectroscopies 11
Novel N-Substituted Indol-3-ylglyoxylamides Probing the LDi and L1/L2 Lipophilic Regions of the Benzodiazepine Receptor Site in Search for Subtype-Selective Ligands. 10
Totale 2.894
Categoria #
all - tutte 11.985
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 11.985


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/20195 0 0 0 0 0 0 0 0 0 0 0 5
2019/2020423 133 25 56 2 55 2 8 9 2 39 27 65
2020/2021534 4 53 73 52 62 83 59 1 59 11 58 19
2021/2022422 18 1 3 3 3 6 5 17 78 3 78 207
2022/2023743 107 64 9 72 73 50 4 48 81 193 29 13
2023/2024276 27 62 105 26 12 8 1 29 1 3 2 0
Totale 2.894