IRIS
COSIMELLI, BARBARA
 Distribuzione geografica
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Continente #
NA - Nord America 1.547
EU - Europa 1.176
AS - Asia 528
AF - Africa 5
SA - Sud America 5
Continente sconosciuto - Info sul continente non disponibili 1
OC - Oceania 1
Totale 3.263
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Nazione #
US - Stati Uniti d'America 1.511
IT - Italia 307
SG - Singapore 275
UA - Ucraina 233
CN - Cina 221
NL - Olanda 204
DE - Germania 111
FI - Finlandia 90
SE - Svezia 90
IE - Irlanda 71
GB - Regno Unito 41
CA - Canada 35
TR - Turchia 12
IN - India 10
RU - Federazione Russa 9
FR - Francia 8
VN - Vietnam 8
CI - Costa d'Avorio 4
BE - Belgio 3
PT - Portogallo 3
BO - Bolivia 2
CL - Cile 2
GR - Grecia 2
MY - Malesia 2
BR - Brasile 1
ES - Italia 1
EU - Europa 1
HR - Croazia 1
LT - Lituania 1
MX - Messico 1
NZ - Nuova Zelanda 1
SK - Slovacchia (Repubblica Slovacca) 1
ZA - Sudafrica 1
Totale 3.263
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Città #
Chandler 267
Jacksonville 251
Singapore 233
Amsterdam 198
Princeton 91
Naples 88
Millbury 79
Boston 73
Nanjing 66
Santa Clara 64
Napoli 48
Wilmington 48
Beijing 38
Boardman 31
Ottawa 29
Nanchang 20
Hebei 19
Jiaxing 17
Des Moines 16
Houston 16
Shenyang 16
Redwood City 14
Woodbridge 14
Ann Arbor 13
Kronberg 12
Ashburn 11
Orange 10
Tianjin 10
Norwalk 9
Dong Ket 8
Seattle 7
Como 6
Kunming 6
Bologna 5
Changsha 5
Dublin 5
Istanbul 5
Jinan 5
Marigliano 5
Changchun 4
Dallas 4
Dronten 4
Milan 4
Redmond 4
Rome 4
Thrissur 4
Brussels 3
Falls Church 3
Hangzhou 3
Lawrence 3
London 3
Shanghai 3
Shenzhen 3
Toronto 3
Torre Del Greco 3
Angri 2
Ardore 2
Athens 2
Augusta 2
Battipaglia 2
Casoria 2
Cava De' Tirreni 2
Dortmund 2
Edmonton 2
Frankfurt am Main 2
La Canada Flintridge 2
La Paz 2
Marabu 2
Marina di Montemarciano 2
Mugnano Di Napoli 2
Pontirolo Nuovo 2
Pune 2
San Francisco 2
Serra 2
Würzburg 2
Atlanta 1
Berlin 1
Bhopal 1
Brescia 1
Buffalo 1
Campobasso 1
Capua 1
Castel Volturno 1
Castenaso 1
Castrop-rauxel 1
Centro 1
Cerro Maggiore 1
Chicago 1
Dearborn 1
Duncan 1
Edinburgh 1
Forino 1
Fort Worth 1
Fremont 1
Gurgaon 1
Helsinki 1
Indiana 1
Johannesburg 1
Leawood 1
Magdeburg 1
Totale 1.978
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Nome #
Studies on enantioselectivity of chiral 4-acetylamino-6-alkyloxy-2-alkylthiopyrimidines acting as antagonists of the human A3 adenosine receptor 86
4-amino-6-alkyloxy-2-alkylthiopyrimidine derivatives as novel non-nucleoside agonists for the adenosine A1 receptor 83
Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A1 adenosine receptor antagonists 64
Determination of the Absolute Configuration of a Chiral Oxadiazol-3-one Calcium Channel Blocker, Resolved by Using Chiral Chromatography, via Concerted Density Functional Theory Calculations of Its Vibrational Circular Dichroism, Electronic Circular Dichroism, and Optical Rotation. 61
Synthesis, Citotoxicity and Apoptosis Induction in Human Tumor Cells by Geiparvarin Analogues 60
2-(Benzimidazol-2-yl)quinoxalines: a Movel Class of Selective Antagonists at Human A(1) and A(3) Adenosine Receptors Designed by 3D Database Searching. 57
Substituent effect on the electrochemical behaviour of some ortho-substituted (aryl)(2-nitrobenzo[b]thiophen-3-yl)amines. A combined experimental and computational study. 56
New Fluorescent 2-Phenylindolglyoxylamide Derivatives as Probes Targeting the Peripheral-Type Benzodiazepine Receptor: Design, Synthesis and Biological Evaluation. 56
New results on the reactivity of 5,6-diamino-4-hydroxy-2-mercaptopyrimidine 55
Diltiazem Analogues: The Last Ten Years on Structure Activity Relationships. 54
Calcium Channel Antagonists Discovered by a Multidisciplinary Approach. 54
Zinc phthalocyanines and corresponding conjugates, their preparation and use in photodynamic therapy and as diagnostic agents. 54
Allosteric modulation of A2B adenosine receptors potentiate the effects of orthosteric receptor agonists to promote mesenchymal stem cell differentiation to osteoblasts 53
3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A2B adenosine receptor antagonists 52
A New Class of Selective Myocardial Calcium Channel Modulators. 2. The Role of the Acetal Chain in Oxadiazol-3-one Derivatives 50
A New Entry to Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidine Derivatives. 50
3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A2B adenosine receptor antagonists 50
5-Amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: A Versatile Scaffold to Obtain Potent and Selective A3 Adenosine Receptor Antagonists. 48
Synthesis and biological evaluation of imidazo[1,2-a]pyrimidines and imidazo[1,2-a]pyridines as new inhibitors of the Wnt/β-catenin signaling 47
Identification of novel indole derivatives acting as inhibitors of the Keap1–Nrf2 interaction 47
A1 adenosine receptor antagonists, 3-aryl[1,2,4]triazino[4,3-a]benzimidazol-4-(10H)-ones (ATBIs) and N-alkyl and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs): Different recognition of bovine and human binding sites 46
Allosteric Modulators of Human A2B Adenosine Receptor 46
TSPO-ligands prevent oxidative damage and inflammatory response in C6 glioma cells by neurosteroid synthesis 46
1H and 13C NMR Study of the Pyrazolo[1,5-a]pyrimidine System. 45
A New Convenient Route to 2-Oxoethoxycoumarins: Key Intermediates in the Synthesis of Natural Products. 44
A novel approach to the evaluation of the importance of steric and electronic effects in SNAr reactions: a computational, thermodynamic, 1H and 13C NMR study of “Meisenheimer-type” adducts in the benzo[b]thiophene series 43
8H-Pyrazolo[5',1':2,3]pyrimido[5,4-d][1,2]diazepine: A New Tricyclic System. 42
Anxiolytic-like Effects of N,N-Dialkyl-2-phenylindol-3-ylglyoxylamides by Modulation of Translocator Protein Promoting Neurosteroid Biosynthesis. 42
Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides 41
On the Synthesis and Reactivity of the Z-2,4-Dinitrophenylhydrazone of 5-Amino-3-benzoyl-1,2,4-oxadiazole. 40
Alkali-metal Complexes with Neutral Molecular Receptors containing Nitrogen Donor Atoms: a Crystallographic and Multinuclear Magnetic Resonance Study. 38
Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism 38
Studies on Azole-to-Azole Interconversion. An Interesting Case of Absence of “Primary Steric Effect” in the Ring-degenerate Equilibration between ortho-Substituted 3-Aroylamino-5-methyl-1,2,4-oxadiazoles and 3-Acetylamino-5-aryl-1,2,4-oxadiazoles in Methanol. 37
A New Synthetic Route to 2,2’:5’,2”-Terthiophene-5-derivatives to Conjugate with Proteins and Monoclonal Antibodies. 37
Natural and Synthetic Geiparvarins Are Strong and Selective MAO-B Inhibitors. Synthesis and SAR Studies. 37
A convenient synthesis of psoralens. 37
2-Phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one derivatives as a new class of adenosine receptor antagonists 37
On the Reactivity of 3-Bromo-2-nitrobenzo[b]thiophene with Nucleophiles: Elucidation of the Base-Catalyzed Mechanism with Rearrangement. 36
Mononuclear Heterocyclic Rearrangements. Part 16. Kinetic Study of the Rearrangement of Some ortho-Substituted Z-Phenylhydrazones of 3-Benzoyl-5-phenyl-1,2,4-oxadiazole into 2-Aryl-4-benzoylamino-5-phenyl-1,2,3-triazoles in Dioxane-Water and in Benzene. 36
On the Nitration of 5-Phenyl- and 3-Methyl-5-phenylisoxazole. 35
On the reaction of 3-bromo-2-nitrobenzo[b]thiophene with some ortho-substituted anilines: an analysis of the products of reaction and of their NMR and MS properties 35
Refinement of the Benzodiazepine Receptor Site Topology by Structure-Activity Relationships of New N-(Heteroarylmethyl)indol-3-ylglyoxylamides. 35
Cardiovascular characterization of [1,4]thiazino[3,4-c][1,2,4]oxadiazol-3-one-derivatives: selective myocardial calcium channel modulators. 34
Substituent effect on the redox potential of some substituted (aryl)(2-nitrobenzo[b]thiophen-3-yl)amines. 34
Studies in organic mass spectrometry. Part 24 Electron ionization mass spectra of some aryl(2-nitrobenzo[b]thiophen-3-yl)amines. 34
Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidine: A New Heterocyclic Ring System. 34
ABCB1 Structural Models, Molecular Docking, and Synthesis of New Oxadiazolothiazin-3-one Inhibitors 34
New geiparvarin analogues from 7-(2-oxoethoxy)coumarins as efficient in vitro antitumoral agents. 33
Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation 33
Enantiomeric 4-Acylamino-6-alkyloxy-2 Alkylthiopyrimidines As Potential A3 Adenosine Receptor Antagonists: HPLC Chiral Resolution and Absolute Configuration Assignment by a Full Set of Chiroptical Spectroscopy 33
Ring-ring Interconversions. Part 3. On the effect of the substituents on the thiazole moiety in the ring-opening/ring-closing reactions of nitrosoimidazo[2,1-b][1,3]thiazoles with hydrochloric acid. 32
Unambiguous Structure Determination of Some Pyrazolo[1,5-a]pyrimidine Derivatives by Multinuclear NMR Spectroscopy. 32
Ring opening of 2-substituted 4-nitrothiophenes with pyrrolidine. Access to new functionalized nitro-unsaturated building blocks. 31
Chemistry of substituted pyrazolo[1,5-a]pyrimidines. Part 5. 7-Oxo-6-[pyrazol-3’(5’)-yl]-4,7-dihydropyrazolo[1,5-a]pyrimidines from 6-ethoxycarbonyl-7-(2-dimethylaminovinyl)-pyrazolo[1,5-a]pyrimidines: elucidation of the reaction mechanism through NMR spectroscopy and X-Ray diffraction analysis. 31
Novel fluorescent triazinobenzimidazole derivatives as probes for labelling human A1 and A2B adenosine receptor subtypes 31
The P-glycoprotein inhibitor diltiazem-like 8-(4-chlorophenyl)-5-methyl-8-[(2Z)-pent-2-en-1-yloxy]-8H-[1,2,4]oxadiazolo[3,4-c][1,4]thiazin-3-one inhibits esterase activity and H3 histone acetylation 31
Chemistry of Substituted Pyrazolo[1,5-a]pyrimidines. Part 3. A Structural Correc¬tion of Pyrazolo[1,5-a][1,3]diazepine Derivative on the Basis of 13C NMR Spectroscopy. 30
Carbon-13 NMR Studies on Azolopyridines. 3-The Isothiazolopyridine Systems. 29
High Affinity Central Benzodiazepine Receptor Ligands: Synthesis and Biological Evaluation of a Series of Phenyltriazolobenzotriazindione Derivatives (PTBTs) 29
Identification of anxiolytic/non sedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the GABAA alfa2 benzodiazepine receptor 29
Absolute configuration and biological profile of two thiazinooxadiazol-3-ones with L-type calcium channel activity: a study of the structural effects 29
Ring-ring interconversions. Part 2. Effect of the Substituent on the Rearrangement of 6-Aryl-3-methyl-5-nitrosoimidazo[2,1-b][1,3]thiazoles into 8-Aryl-8-hydroxy-5-methyl-8H-[1,4]thiazino[3,4-c][1,2,4]oxadiazol-3-ones. A Novel Class of Potential Antitumor Agents. 28
The First Kinetic Evidence for Acid Catalysis in a Monocyclic Rearrangement of Heterocycles: Conversion of the Z-Phenylhydrazone of 5-Amino-3-benzoyl-1,2,4-oxadiazole into N,5-Diphenyl-2H-1,2,3-triazol-4-ylurea 28
Novel Irreversible Fluorescent Probes Targeting the 18kDa Translocator Protein: Synthesis and Biological Characterization. 28
p53 Functional Inhibitors Behaving Like Pifithrin-? Counteract the Alzheimer Peptide Non-?-amyloid Component Effects in Human SH-SY5Y Cells 28
Ring-ring Interconversions of Nitrosoimidazoles. The Effect of Some Condensed Six-membered Rings on the Reactivity. 27
Regioselective Synthesis of 4-Acetyl- and 5-Acetyl-3-methylisoxazole: their Conversion into Silyl- and Methyl Enol Ethers. 27
From the Pharmacophore to the Homology Model of the Benzodiazepine Receptor: The Indolyglyoxylamides Affair. 27
Synthesis and L-type calcium channel blocking activity of new chiral oxadiazolothiazinones 27
Complete 1H (600 MHz) and 13C NMR Spectral Assignment of 3,4-bis[(3,4-Dimethoxyphenyl)methyl]dihydro-(3R-trans)-2(3H)-furanone (Matairesinol Dimethyl Ether), a Naturally Occurring Dibenzylbutyrolactone Lignan. 26
Synthesis and antimycotic activity of new unsymmetrical substituted zinc phthalocyanines. 25
Chemistry of Substituted Pyrazolo[1,5-a]pyrimidines. Part 4. A Structural Correction of a Series of Pyrazolo[5',1':2,3]pyrimido[5,4-d][1,3]diazepines on the Basis of NMR Spectroscopy and X-Ray Diffraction Analysis. 25
Ring-ring interconversion: the rearrangement of 6-(4-chlorophenyl)-3-methyl-5-nitrosoimidazo[2,1-b][1,3]thiazole into 8-(4-chlorophenyl)-8-hydroxy-5-methyl-8H-[1,4]thiazino[3,4-c][1,2,4]oxadiazol-3-one. Elucidation of the reaction product through spectroscopic and X-ray crystal structure analysis. 25
Derivatives of 4-Amino-6-hydroxy-2-mercaptopyrimidine as Novel, Potent, and Selective A3 Adenosine Receptor Antagonists 25
An Unexpected Pathway to Enantiomerization of Hemithioketals in Toluene Involving a Dimeric Transition State: A Combined Experimental and Computational Study 25
New 5-(2-ethenylsubstituted)-3(2H)-furanones with in vitro antiproliferative activity 24
ortho-Substituted (aryl)(3-nitrobenzo[b]thiophen-2-yl)amines: study of the electrochemical behavior 24
Selective and Practical Oxidation of Sulfides to Diastereopure Sulfoxides: A Combined Experimental and Computational Investigation 24
L-Type calcium channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives 22
Derivatives of benzimidazol-2-ylquinoline and benzimidazol-2-ylisoquinoline as selective A1 adenosine receptor antagonists with stimulant activity on human colon motility 22
On the reactivity of nitrosoimidazoles with acids (the Cusmano-Ruccia reaction): a continuous source of new ring-into-ring interconversion 22
Modulation of A2B adenosine receptor by 1-Benzyl-3-ketoindole derivatives 21
Preliminary Finding on a New Calcium Channel Entry Blocker Chemotype: 5,6-Diamino-4-hydroxy-2-mercaptopyrimidine Derivatives 21
First example of Diels-Alder reaction of 4-(1-ethenylsubstituted)-3-methylisoxazoles with acetylenedicarboxylate 19
Discovery of novel and cardioselective diltiazem-like calcium channel blockers via virtual screening. 19
The Boulton–Katritzky Reaction: A Kinetic Study of the Effect of 5-Nitrogen Substituents on the Rearrangement of Some (Z)-Phenylhydrazones of 3-Benzoyl-1,2,4-oxadiazoles 19
From the central benzodiazepine receptor to the adenosine receptors exploiting the 3-diketoindole moiety 19
Playing with Opening and Closing of Heterocycles: Using the Cusmano-Ruccia Reaction to Develop a Novel Class of Oxadiazolothiazinones, Active as Calcium Channel Modulators and P-Glycoprotein Inhibitors 18
Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators 17
Novel N-Substituted Indol-3-ylglyoxylamides Probing the LDi and L1/L2 Lipophilic Regions of the Benzodiazepine Receptor Site in Search for Subtype-Selective Ligands. 16
Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein 15
Determination of the absolute configuration of the enantiomers of an oxadiazol-3-one calcium channel blocker, resolved by chiral HPLC, via concerted use of three chiroptical spectroscopies 15
Inhibition of MDR1 activity in vitro by a novel class of diltiazem analogues: towards new candidates 14
Synthesis and biological evaluation on human glioblastoma cells of novel pyrazolo[3,4-d]pyrimidine adenosine A(3) receptor antagonists 14
Totale 3.349
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Categoria #
all - tutte 16.592
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 16.592
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020152 0 0 0 0 0 2 8 9 2 39 27 65
2020/2021534 4 53 73 52 62 83 59 1 59 11 58 19
2021/2022422 18 1 3 3 3 6 5 17 78 3 78 207
2022/2023743 107 64 9 72 73 50 4 48 81 193 29 13
2023/2024356 27 62 105 26 12 8 1 29 1 3 44 38
2024/2025375 124 167 6 4 31 43 0 0 0 0 0 0
Totale 3.349