IRIS
Di Leva, Francesco Saverio
 Distribuzione geografica
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Continente #
NA - Nord America 885
EU - Europa 745
AS - Asia 210
AF - Africa 28
Continente sconosciuto - Info sul continente non disponibili 1
Totale 1.869
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Nazione #
US - Stati Uniti d'America 859
IT - Italia 439
CN - Cina 157
DE - Germania 116
NL - Olanda 54
IE - Irlanda 33
CI - Costa d'Avorio 28
GB - Regno Unito 28
FI - Finlandia 26
CA - Canada 24
VN - Vietnam 20
IN - India 15
UA - Ucraina 11
JP - Giappone 8
SE - Svezia 8
BG - Bulgaria 6
FR - Francia 6
HR - Croazia 4
IR - Iran 4
CH - Svizzera 3
ES - Italia 2
HK - Hong Kong 2
MT - Malta 2
RS - Serbia 2
A1 - Anonimo 1
BY - Bielorussia 1
DK - Danimarca 1
EE - Estonia 1
GR - Grecia 1
IL - Israele 1
IS - Islanda 1
KR - Corea 1
MX - Messico 1
PA - Panama 1
PK - Pakistan 1
SG - Singapore 1
Totale 1.869
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Città #
Chandler 184
Napoli 87
Nanjing 58
Millbury 55
Amsterdam 54
Des Moines 43
Ashburn 41
Princeton 41
Naples 40
Beijing 36
Boston 30
Ottawa 23
Wilmington 23
Dong Ket 20
Lawrence 17
Nürnberg 17
Nanchang 13
Leawood 12
Hebei 11
Pune 11
Angri 10
Jacksonville 10
Milan 9
Houston 8
Salerno 8
Shenyang 8
Florence 7
Norwalk 7
Rome 7
Bari 6
Castellammare Di Stabia 6
Jiaxing 6
Quarto 6
Sofia 6
Tianjin 6
Woodbridge 6
Amorosi 5
Changsha 5
Fairfield 5
Parma 5
Redwood City 5
Seattle 5
Enfield 4
Frattamaggiore 4
Ikari 4
Piombino 4
Zagreb 4
Battipaglia 3
Cagliari 3
Caserta 3
Darmstadt 3
Dublin 3
Jinan 3
Mugnano di Napoli 3
Palermo 3
Redmond 3
Rende 3
Tokyo 3
Varedo 3
Ann Arbor 2
Arzano 2
Augusta 2
Bacoli 2
Boardman 2
Bologna 2
Garching 2
Hong Kong 2
Imsida 2
Issiglio 2
Kunming 2
London 2
Los Angeles 2
Monza 2
Mugnano Di Napoli 2
Ningbo 2
Niscemi 2
Orange 2
Pescara 2
Philadelphia 2
Rho 2
Sagrado 2
Santa Maria Capua Vetere 2
Scuola 2
Seregno 2
Serra 2
Siena 2
Worcester 2
Zhengzhou 2
Acerra 1
Altamura 1
Ardabil 1
Avellino 1
Baronissi 1
Belgrade 1
Belmonte Mezzagno 1
Bonn 1
Bovisio Masciago 1
Brescia 1
Casoria 1
Catanzaro 1
Totale 1.088
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Nome #
Pharmacophoric Modifications Lead to Superpotent avb3 Integrin Ligands with Suppressed a5b1 Activity 129
Click-Chemistry (CuAAC) Trimerization of an αvβ6 Integrin Targeting Ga-68-Peptide: Enhanced Contrast for in-Vivo PET Imaging of Human Lung Adenocarcinoma Xenografts 62
Design, synthesis and pharmacological characterization of novel potent nonsteroidal agonists of the farnesoid X receptor 62
Hyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists 58
Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury 57
Targeting bile acid receptors: discovery of a potent and selective Farnesoid X receptor agonist as a new lead in the pharmacological approach to liver diseases 54
Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists 54
Discovery of UDCA derivatives as new modulators of bile acid receptors 50
From a Helix to a Small Cycle: Metadynamics-Inspired αvβ6 Integrin Selective Ligands 47
Modification on Ursodeoxycholic Acid (UDCA) Scaffold. Discovery of Bile Acid Derivatives As Selective Agonists of Cell-Surface G-Protein Coupled Bile Acid Receptor 1 (GP-BAR1) 46
Exploring the N-Terminal Region of C-X-C Motif Chemokine 12 (CXCL12): Identification of Plasma-Stable Cyclic Peptides As Novel, Potent C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonists 46
Targeting the Human Telomeric G-Quadruplex Through Virtual Screening Calculations 44
Marine and semi-sinthetic hydroxystroids as new scaffolds for pregnane X receptor modulation 43
Disulfide bond replacement with 1,4‐ and 1,5‐disubstituted [1,2,3]‐triazole on C‐X‐C chemokine receptor type 4 (CXCR4) peptide ligands: small changes that make big differences 43
Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors 42
Targeting SARS-CoV-2 Proteases and Polymerase for COVID-19 Treatment: State of the Art and Future Opportunities 42
Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment 40
Structure-Activity Relationships and Biological Characterization of a Novel, Potent, and Serum Stable C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonist 40
Ligand-Based NMR Study of C-X-C Chemokine Receptor Type 4 (CXCR4)-Ligand Interactions on Living Cancer Cells 40
Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1 40
Design and synthesis of hyodeoxycholic acid derivatives as GPBAR1 receptor modulators useful in the treatment of colon inflammation 37
Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands 36
Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties 36
GPBAR1 activation by C6-substituted hyodeoxycholane analogues protect against colitis 35
Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism 34
Computer-Aided Drug Design Unveils the Structural Requisites for Bile Acid Receptors Modulation 34
Halting the Spread of Herpes Simplex Virus-1: The Discovery of an Effective Dual αvβ6/αvβ8 Integrin Ligand 34
State-of-the-art methodologies for the discovery and characterization of DNA G-Quadruplex binders 32
Epoxide functionalization on cholane side chains in the identification of G-protein coupled bile acid receptor (GPBAR1) selective agonists 31
Biselectivity of isoDGR Peptides for Fibronectin Binding Integrin Subtypes α5β1 and αvβ6: Conformational Control through Flanking Amino Acids 29
Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination 28
Selective Targeting of Integrin αvβ8 by a Highly Active Cyclic Peptide 28
Exploring the chemical space of G-quadruplex binders: Discovery of a novel chemotype targeting the human telomeric sequence 27
Potent dual agonists of nuclear and membrane bile acid receptors 27
Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors 27
Basic Quinolinonyl Diketo Acid Derivatives as Inhibitors of HIV Integrase and their Activity against RNase H Function of Reverse Transcriptase 26
Discovery of amine bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 26
Structural Insight into the Binding Mode of FXR and GPBAR1 Modulators 26
Targeting the KRAS oncogene: Synthesis, physicochemical and biological evaluation of novel G-Quadruplex DNA binders 26
Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: A first round of lead optimization. 25
The organometallic ferrocene exhibits amplified anti-tumor activity by targeted delivery via highly selective ligands to αvβ3, αvβ6, or α5β1 integrins 25
Elucidating the Binding Behavior of Highly Potent COX-2 Selective Inhibitors 24
Bioinformatics and Biosimulations as Toolbox for Peptides and Peptidomimetics Design: Where Are We? 24
N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase 23
Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design 21
Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme 21
The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II 20
N-Methylation of isoDGR Peptides: Discovery of a Selective α5β1-Integrin Ligand as a Potent Tumor Imaging Agent 20
Synthesis of new oxadiazole derivatives as potent and selective FXR antagonists 20
Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma 19
Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75 19
Discovery of 2,3-Diaminoindole Derivatives as a Novel Class of NOD Antagonists 18
Protein Flexibility in Virtual Screening: The BACE-1 Case Study 18
Overcoming the Lack of Oral Availability of Cyclic Hexapeptides: Design of a Selective and Orally Available Ligand for the Integrin αvβ3 18
Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists 17
Phenylpyrazolo[1,5-a]quinazolin-5(4H)-one: a suitable scaffold for the development of non-camptothecin Topoisomerase I (Top1) inhibitors. 17
Stable Peptides Instead of Stapled Peptides: Highly Potent αvβ6-Selective Integrin Ligands 17
Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by diketo acid derivatives 17
Mechanistic insight into ligand binding to G-quadruplex DNA 15
Ligand Binding to Telomeric DNA G-quadruplex through Metadynamics Calculations 14
New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H 14
Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane x receptor modulation. 13
Rational Improvement of the Affinity and Selectivity of Integrin Binding of Grafted Lasso Peptides 12
The Inhibition of DNA Viruses by the Amphibian Antimicrobial Peptide Temporin G: A Virological Study Addressing HSV-1 and JPCyV 8
Exploring the 1,3-benzoxazine chemotype for cannabinoid receptor 2 as a promising anti-cancer therapeutic 7
A combined approach of structure‐based virtual screening and NMR to interrupt the PD‐1/PD‐L1 axis: Biphenyl‐benzimidazole containing compounds as novel PD‐L1 inhibitors 3
Molecular View on the iRGD Peptide Binding Mechanism: Implications for Integrin Activity and Selectivity Profiles 3
Totale 2.090
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Categoria #
all - tutte 7.157
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 7.157
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/201923 0 0 0 0 0 0 0 0 0 0 3 20
2019/2020301 85 4 6 30 19 12 16 28 7 30 34 30
2020/2021319 34 11 11 14 45 55 36 17 30 12 25 29
2021/2022343 3 1 3 10 9 15 7 20 36 42 64 133
2022/2023481 61 31 17 27 65 52 0 48 72 59 36 13
2023/2024303 25 61 41 33 14 27 13 51 17 18 3 0
Totale 2.090