IRIS
Di Leva, Francesco Saverio
 Distribuzione geografica
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Continente #
EU - Europa 2.500
AS - Asia 2.351
NA - Nord America 1.714
SA - Sud America 341
AF - Africa 75
Continente sconosciuto - Info sul continente non disponibili 1
OC - Oceania 1
Totale 6.983
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Nazione #
US - Stati Uniti d'America 1.650
SG - Singapore 1.260
RU - Federazione Russa 937
IT - Italia 697
CN - Cina 565
DE - Germania 384
BR - Brasile 275
HK - Hong Kong 187
VN - Vietnam 175
FI - Finlandia 155
GB - Regno Unito 73
NL - Olanda 72
FR - Francia 42
IN - India 37
IE - Irlanda 35
AR - Argentina 34
CA - Canada 34
CI - Costa d'Avorio 28
ZA - Sudafrica 22
KR - Corea 21
JP - Giappone 20
BD - Bangladesh 19
UA - Ucraina 19
MX - Messico 18
SE - Svezia 17
TR - Turchia 17
IQ - Iraq 16
PL - Polonia 13
EC - Ecuador 8
ES - Italia 8
ID - Indonesia 8
AT - Austria 7
BG - Bulgaria 7
CH - Svizzera 7
CO - Colombia 7
LT - Lituania 6
MA - Marocco 6
VE - Venezuela 6
BE - Belgio 5
PA - Panama 5
PY - Paraguay 5
HR - Croazia 4
IL - Israele 4
IR - Iran 4
EG - Egitto 3
JM - Giamaica 3
PK - Pakistan 3
UZ - Uzbekistan 3
CL - Cile 2
DZ - Algeria 2
ET - Etiopia 2
GE - Georgia 2
KE - Kenya 2
MT - Malta 2
OM - Oman 2
RS - Serbia 2
SA - Arabia Saudita 2
SN - Senegal 2
TN - Tunisia 2
UY - Uruguay 2
A1 - Anonimo 1
AE - Emirati Arabi Uniti 1
AL - Albania 1
AO - Angola 1
BJ - Benin 1
BN - Brunei Darussalam 1
BO - Bolivia 1
BY - Bielorussia 1
CG - Congo 1
CZ - Repubblica Ceca 1
DK - Danimarca 1
DM - Dominica 1
EE - Estonia 1
GM - Gambi 1
GP - Guadalupe 1
GU - Guam 1
IS - Islanda 1
JO - Giordania 1
MY - Malesia 1
NE - Niger 1
NO - Norvegia 1
PE - Perù 1
PR - Porto Rico 1
PT - Portogallo 1
TH - Thailandia 1
TT - Trinidad e Tobago 1
TW - Taiwan 1
ZW - Zimbabwe 1
Totale 6.983
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Città #
Singapore 584
Moscow 238
Munich 211
Hong Kong 187
Beijing 186
Chandler 182
Naples 167
Ashburn 154
Santa Clara 119
Hefei 116
Helsinki 100
Dallas 91
Napoli 87
Amsterdam 60
Los Angeles 60
Nanjing 59
Millbury 55
Ho Chi Minh City 51
Boston 43
Des Moines 43
Princeton 41
Redondo Beach 35
Hanoi 29
Ottawa 25
Rome 25
São Paulo 23
Wilmington 23
Dong Ket 20
New York 20
The Dalles 18
Lawrence 17
Nürnberg 17
Seoul 17
Buffalo 16
Frankfurt am Main 16
Milan 15
Tokyo 15
Turku 14
Nanchang 13
Seattle 13
Warsaw 13
Houston 12
Leawood 12
Hebei 11
Pune 11
Angri 10
Atlanta 10
Baghdad 10
Brooklyn 10
Chicago 10
Düsseldorf 10
Falkenstein 10
Jacksonville 10
Stockholm 10
Ankara 9
Bari 9
Biên Hòa 9
Kochi 9
London 9
Nuremberg 9
Tianjin 9
Changsha 8
Johannesburg 8
Lauterbourg 8
Manchester 8
Mexico City 8
Portsmouth 8
Rio de Janeiro 8
Salerno 8
Shenyang 8
Campinas 7
Chennai 7
Florence 7
Istanbul 7
Lappeenranta 7
Ninh Bình 7
Norwalk 7
Parma 7
Castellammare Di Stabia 6
Curitiba 6
Denver 6
Hải Dương 6
Jiaxing 6
Jyväskylä 6
Porto Alegre 6
Quarto 6
Shanghai 6
Sofia 6
Woodbridge 6
Amorosi 5
Bexley 5
Bologna 5
Brasília 5
Brussels 5
Da Nang 5
Dhaka 5
Fairfield 5
Panama City 5
Philadelphia 5
Poplar 5
Totale 3.666
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Nome #
Discovery of UDCA derivatives as new modulators of bile acid receptors 267
Potent dual agonists of nuclear and membrane bile acid receptors 243
Pharmacophoric Modifications Lead to Superpotent avb3 Integrin Ligands with Suppressed a5b1 Activity 193
Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination 144
Design, synthesis and pharmacological characterization of novel potent nonsteroidal agonists of the farnesoid X receptor 142
Discovery of 2,3-Diaminoindole Derivatives as a Novel Class of NOD Antagonists 138
Click-Chemistry (CuAAC) Trimerization of an αvβ6 Integrin Targeting Ga-68-Peptide: Enhanced Contrast for in-Vivo PET Imaging of Human Lung Adenocarcinoma Xenografts 138
Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury 137
Development and Nanoparticle-Mediated Delivery of Novel MDM2/MDM4 Heterodimer Peptide Inhibitors to Enhance 5-Fluorouracil Nucleolar Stress in Colorectal Cancer Cells 132
Marine and semi-sinthetic hydroxystroids as new scaffolds for pregnane X receptor modulation 129
Exploring the N-Terminal Region of C-X-C Motif Chemokine 12 (CXCL12): Identification of Plasma-Stable Cyclic Peptides As Novel, Potent C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonists 127
Hyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists 127
Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design 123
Targeting the Human Telomeric G-Quadruplex Through Virtual Screening Calculations 120
Paper-based electrochemical device for early detection of integrin αvβ6 expressing tumors 115
Design and synthesis of hyodeoxycholic acid derivatives as GPBAR1 receptor modulators useful in the treatment of colon inflammation 114
Structure-Activity Relationships and Biological Characterization of a Novel, Potent, and Serum Stable C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonist 113
Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists 112
Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1 111
Computer-Aided Drug Design Unveils the Structural Requisites for Bile Acid Receptors Modulation 108
From a Helix to a Small Cycle: Metadynamics-Inspired αvβ6 Integrin Selective Ligands 108
Disulfide bond replacement with 1,4‐ and 1,5‐disubstituted [1,2,3]‐triazole on C‐X‐C chemokine receptor type 4 (CXCR4) peptide ligands: small changes that make big differences 108
Ligand-Based NMR Study of C-X-C Chemokine Receptor Type 4 (CXCR4)-Ligand Interactions on Living Cancer Cells 106
A combined approach of structure‐based virtual screening and NMR to interrupt the PD‐1/PD‐L1 axis: Biphenyl‐benzimidazole containing compounds as novel PD‐L1 inhibitors 105
State-of-the-art methodologies for the discovery and characterization of DNA G-Quadruplex binders 103
Modification on Ursodeoxycholic Acid (UDCA) Scaffold. Discovery of Bile Acid Derivatives As Selective Agonists of Cell-Surface G-Protein Coupled Bile Acid Receptor 1 (GP-BAR1) 102
Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties 98
Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme 95
Deepening bis-(thio)carbohydrazones conformational dynamics and hydrogen bond interactions in a non-protic solvent: DFT, molecular dynamics, NMR, and Raman investigations 94
Targeting the KRAS oncogene: Synthesis, physicochemical and biological evaluation of novel G-Quadruplex DNA binders 93
Elucidating the Binding Behavior of Highly Potent COX-2 Selective Inhibitors 92
Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists 92
GPBAR1 activation by C6-substituted hyodeoxycholane analogues protect against colitis 92
Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors 91
Pharmacological targeting of smoothened receptor cysteine-rich domain by Budesonide promotes in vitro myelination 91
Basic Quinolinonyl Diketo Acid Derivatives as Inhibitors of HIV Integrase and their Activity against RNase H Function of Reverse Transcriptase 89
Discovery of amine bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 89
Halting the Spread of Herpes Simplex Virus-1: The Discovery of an Effective Dual αvβ6/αvβ8 Integrin Ligand 89
Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors 87
Targeting SARS-CoV-2 Proteases and Polymerase for COVID-19 Treatment: State of the Art and Future Opportunities 86
Stable Peptides Instead of Stapled Peptides: Highly Potent αvβ6-Selective Integrin Ligands 85
Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment 85
Epoxide functionalization on cholane side chains in the identification of G-protein coupled bile acid receptor (GPBAR1) selective agonists 85
Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by diketo acid derivatives 85
Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: A first round of lead optimization. 84
Targeting bile acid receptors: discovery of a potent and selective Farnesoid X receptor agonist as a new lead in the pharmacological approach to liver diseases 84
Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75 84
Biselectivity of isoDGR Peptides for Fibronectin Binding Integrin Subtypes α5β1 and αvβ6: Conformational Control through Flanking Amino Acids 83
Phenylpyrazolo[1,5-a]quinazolin-5(4H)-one: a suitable scaffold for the development of non-camptothecin Topoisomerase I (Top1) inhibitors. 81
Protein Flexibility in Virtual Screening: The BACE-1 Case Study 81
Overcoming the Lack of Oral Availability of Cyclic Hexapeptides: Design of a Selective and Orally Available Ligand for the Integrin αvβ3 81
Ex.50.T aptamer impairs tumor–stroma cross-talk in breast cancer by targeting gremlin-1 80
The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II 80
The organometallic ferrocene exhibits amplified anti-tumor activity by targeted delivery via highly selective ligands to αvβ3, αvβ6, or α5β1 integrins 77
Rational Improvement of the Affinity and Selectivity of Integrin Binding of Grafted Lasso Peptides 76
Ligand Binding to Telomeric DNA G-quadruplex through Metadynamics Calculations 76
Design, synthesis and characterization of aryl bis-guanyl hydrazones as RNA binders of C9orf72 G4C2 extended repeats 74
Molecular View on the iRGD Peptide Binding Mechanism: Implications for Integrin Activity and Selectivity Profiles 72
Bioinformatics and Biosimulations as Toolbox for Peptides and Peptidomimetics Design: Where Are We? 71
Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands 70
Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism 67
Design, Synthesis, and Anticancer Activity of Drug-like Iron Chelators/G-Quadruplex Binders as Synergic Dual Targeting Agents 65
Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma 65
Targeting Glioblastoma Stem Cells via EphA2: Structural Insights into the RNA Aptamer A40s for Precision Therapy 64
Structural Insight into the Binding Mode of FXR and GPBAR1 Modulators 63
Exploring the chemical space of G-quadruplex binders: Discovery of a novel chemotype targeting the human telomeric sequence 62
N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase 62
Selective Targeting of Integrin αvβ8 by a Highly Active Cyclic Peptide 62
Exploring the 1,3-benzoxazine chemotype for cannabinoid receptor 2 as a promising anti-cancer therapeutic 61
Synthesis of new oxadiazole derivatives as potent and selective FXR antagonists 59
Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane x receptor modulation. 53
N-Methylation of isoDGR Peptides: Discovery of a Selective α5β1-Integrin Ligand as a Potent Tumor Imaging Agent 53
Mechanistic insight into ligand binding to G-quadruplex DNA 51
New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H 47
Switching Roles─Exploring Concentration-Dependent Agonistic versus Antagonistic Behavior of Integrin Ligands 39
Vincristine Beyond Mitosis: Uncovering a First Link to G-Quadruplex DNA in Cancer Cells 16
Totale 7.226
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Categoria #
all - tutte 21.502
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 21.502
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021204 0 0 0 0 0 55 36 17 30 12 25 29
2021/2022343 3 1 3 10 9 15 7 20 36 42 64 133
2022/2023476 61 31 15 26 65 52 0 48 72 59 35 12
2023/2024394 24 61 40 32 14 27 13 51 17 18 63 34
2024/20252.482 106 117 16 54 47 205 321 198 203 207 752 256
2025/20262.568 482 363 537 399 692 95 0 0 0 0 0 0
Totale 7.226