We investigated the ultrasonication-mediated effects on the Fmoc-based solid-phase peptide synthesis (SPPS). Our study culminated with the development of an ultrasound-assisted strategy (US-SPPS) that allowed for the synthesis of different biologically active peptides (up to 44-mer), with a remarkable savings of material and reaction time. Noteworthy, ultrasonic irradiation did not exacerbate the main side reactions and improved the synthesis of peptides endowed with "difficult sequences", placing the US-SPPS among the current high-efficient peptide synthetic strategies.
Boosting Fmoc Solid-Phase Peptide Synthesis by Ultrasonication / Merlino, F.; Tomassi, S.; Yousif, A. M.; Messere, A.; Marinelli, L.; Grieco, P.; Novellino, E.; Cosconati, S.; Di Maro, S.. - In: ORGANIC LETTERS. - ISSN 1523-7060. - 21:16(2019), pp. 6378-6382. [10.1021/acs.orglett.9b02283]
Boosting Fmoc Solid-Phase Peptide Synthesis by Ultrasonication
Merlino F.Co-primo
;Tomassi S.Co-primo
;Yousif A. M.;Marinelli L.;Grieco P.;Novellino E.;
2019
Abstract
We investigated the ultrasonication-mediated effects on the Fmoc-based solid-phase peptide synthesis (SPPS). Our study culminated with the development of an ultrasound-assisted strategy (US-SPPS) that allowed for the synthesis of different biologically active peptides (up to 44-mer), with a remarkable savings of material and reaction time. Noteworthy, ultrasonic irradiation did not exacerbate the main side reactions and improved the synthesis of peptides endowed with "difficult sequences", placing the US-SPPS among the current high-efficient peptide synthetic strategies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
