The melanocortin receptors 3 and 4 control energy homeostasis, food-intake behavior, and correlated pathophysiological conditions. The melanocortin-4 receptor (MC4R) has been broadly investigated. In contrast, the knowledge related to physiological roles of the melanocortin-3 receptor (MC3R) is lacking because of the limited number of known MC3R selective ligands. Here, we report the design, synthesis, biological activity, conformational analysis, and docking with receptors of two potent and selective agonists at the human MC3 receptor.
Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor / Carotenuto, Alfonso; Merlino, Francesco; Cai, Minying; Brancaccio, Diego; Yousif, ALI MUNAIM; Novellino, Ettore; Hruby, Victor J.; Grieco, Paolo. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - 58:24(2015), pp. 9773-9778. [10.1021/acs.jmedchem.5b01285]
Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor
CAROTENUTO, ALFONSOCo-primo
;MERLINO, FRANCESCOCo-primo
;BRANCACCIO, DIEGO;YOUSIF, ALI MUNAIM;NOVELLINO, ETTORE;GRIECO, PAOLO
2015
Abstract
The melanocortin receptors 3 and 4 control energy homeostasis, food-intake behavior, and correlated pathophysiological conditions. The melanocortin-4 receptor (MC4R) has been broadly investigated. In contrast, the knowledge related to physiological roles of the melanocortin-3 receptor (MC3R) is lacking because of the limited number of known MC3R selective ligands. Here, we report the design, synthesis, biological activity, conformational analysis, and docking with receptors of two potent and selective agonists at the human MC3 receptor.| File | Dimensione | Formato | |
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