Mistrafficking of CFTR protein caused by F508del, the most frequent mutation in cystic fibrosis (CF), can be corrected by cell incubation at low temperature, an effect that may be mediated by altered expression of proteostasis genes.

Evaluation of a systems biology approach to identify pharmacological correctors of the mutant CFTR chloride channel / Pesce, Emanuela; Gorrieri, Giulia; Sirci, Francesco; Napolitano, Francesco; Carrella, Diego; Caci, Emanuela; Tomati, Valeria; Zegarra Moran, Olga; DI BERNARDO, Diego; Galietta, Luis J. V.. - In: JOURNAL OF CYSTIC FIBROSIS. - ISSN 1873-5010. - (2016). [10.1016/j.jcf.2016.02.009]

Evaluation of a systems biology approach to identify pharmacological correctors of the mutant CFTR chloride channel

DI BERNARDO, DIEGO;Galietta, Luis J. V.
2016

Abstract

Mistrafficking of CFTR protein caused by F508del, the most frequent mutation in cystic fibrosis (CF), can be corrected by cell incubation at low temperature, an effect that may be mediated by altered expression of proteostasis genes.
2016
Evaluation of a systems biology approach to identify pharmacological correctors of the mutant CFTR chloride channel / Pesce, Emanuela; Gorrieri, Giulia; Sirci, Francesco; Napolitano, Francesco; Carrella, Diego; Caci, Emanuela; Tomati, Valeria; Zegarra Moran, Olga; DI BERNARDO, Diego; Galietta, Luis J. V.. - In: JOURNAL OF CYSTIC FIBROSIS. - ISSN 1873-5010. - (2016). [10.1016/j.jcf.2016.02.009]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/634937
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