The inhibitory effect of one of the major proteins secreted by the rat seminal vesicles (SV-IV) on platelet-activating factor (PAF)-induced biological activities was investigated in vivo. SV-IV was found to prevent dose dependently both hypotension and acute bronchospasm caused by PAF administration in guinea-pigs. In addition, SV-IV inhibited both PAF- and ethanol-induced gastric mucosal injury in a dose-dependent manner.
Protective Effect of Sv-IV On Platelet-activating Factor-induced Hypotension, Bronchoconstriction and Gastric-mucosal Injury / P., Persico; S., Metafora; F., Mancuso; Calignano, Antonio; A., Venturelli; Mariniello, Loredana; Porta, Raffaele. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - STAMPA. - 241:(1993), pp. 71-74. [10.1016/0014-2999(93)90934-A]
Protective Effect of Sv-IV On Platelet-activating Factor-induced Hypotension, Bronchoconstriction and Gastric-mucosal Injury
CALIGNANO, ANTONIO;MARINIELLO, LOREDANA;PORTA, RAFFAELE
1993
Abstract
The inhibitory effect of one of the major proteins secreted by the rat seminal vesicles (SV-IV) on platelet-activating factor (PAF)-induced biological activities was investigated in vivo. SV-IV was found to prevent dose dependently both hypotension and acute bronchospasm caused by PAF administration in guinea-pigs. In addition, SV-IV inhibited both PAF- and ethanol-induced gastric mucosal injury in a dose-dependent manner.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
