A series of 2-cyclopentyl-5-amidobenzotriazole derivatives has been prepared and characterized. Shake-flask partition coefficients (log P) and capacity factors (log k') were experimentally determined and correlated through regression analysis. The in vitro antimicrobial activity of prepared compounds against gram-positive, gram-negative bacteria and Candida albicans are discussed in function of their structural features. Some derivatives are characterized by interesting antimicrobial activities.
Synthesis and antimicrobial activities of 5-amidobenzotriazole derivatives / Caliendo, Giuseppe; Novellino, Ettore; Saliocco, G.; Santagada, Vincenzo; Silipo, V.; Vittoria, A.. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - STAMPA. - 25:4(1990), pp. 343-350. [10.1016/0223-5234(90)90118-M]
Synthesis and antimicrobial activities of 5-amidobenzotriazole derivatives
CALIENDO, GIUSEPPE;NOVELLINO, ETTORE;SANTAGADA, VINCENZO;
1990
Abstract
A series of 2-cyclopentyl-5-amidobenzotriazole derivatives has been prepared and characterized. Shake-flask partition coefficients (log P) and capacity factors (log k') were experimentally determined and correlated through regression analysis. The in vitro antimicrobial activity of prepared compounds against gram-positive, gram-negative bacteria and Candida albicans are discussed in function of their structural features. Some derivatives are characterized by interesting antimicrobial activities.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
