The synthesis of a series of proline derivatives (1a-e and 2a-b) as pure isomers is described. These compounds were evaluated in vitro for their ability to inhibit angiotensin converting enzyme (ACE) and compared to the potency of captopril taken as a reference drug. They showed only a weak ACE inhibitory activity.
Synthesis and biological evaluation of proline derivatives as potential angiotensin converting enzyme inhibitor / G., Giugliano; Grieco, Paolo; Ialenti, Armando; M., Mottola; Perissutti, Elisa; Santagada, Vincenzo. - In: BOLLETTINO DELLA SOCIETA' ITALIANA DI BIOLOGIA SPERIMENTALE. - ISSN 0037-8771. - STAMPA. - 72:(1996), pp. 29-36.
Synthesis and biological evaluation of proline derivatives as potential angiotensin converting enzyme inhibitor.
GRIECO, PAOLO;IALENTI, ARMANDO;PERISSUTTI, ELISA;SANTAGADA, VINCENZO
1996
Abstract
The synthesis of a series of proline derivatives (1a-e and 2a-b) as pure isomers is described. These compounds were evaluated in vitro for their ability to inhibit angiotensin converting enzyme (ACE) and compared to the potency of captopril taken as a reference drug. They showed only a weak ACE inhibitory activity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
