Hydrogen sulphide is an important mediator of gastric mucosal defence. The use of non‐steroidal anti‐inflammatory drugs continues to be limited by their toxicity, particularly in the upper gastrointestinal tract. We evaluated the gastrointestinal safety and anti‐inflammatory efficacy of a novel hydrogen sulphide‐releasing derivative of naproxen, ATB‐346 [2‐(6‐methoxy‐napthalen‐2‐yl)‐propionic acid 4‐thiocarbamoyl‐phenyl ester]
Markedly Reduced Toxicity of a Hydrogen Sulfide-Releasing Derivative of Naproxen (ATB-346) / Wallace, J. L.; Caliendo, Giuseppe; Santagada, Vincenzo; Cirino, Giuseppe. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 1476-5381. - STAMPA. - 159:6(2010), pp. 1236-1246. [10.1111/j.1476-5381.2009.00611.x]
Markedly Reduced Toxicity of a Hydrogen Sulfide-Releasing Derivative of Naproxen (ATB-346)
CALIENDO, GIUSEPPE;SANTAGADA, VINCENZO;CIRINO, GIUSEPPE
2010
Abstract
Hydrogen sulphide is an important mediator of gastric mucosal defence. The use of non‐steroidal anti‐inflammatory drugs continues to be limited by their toxicity, particularly in the upper gastrointestinal tract. We evaluated the gastrointestinal safety and anti‐inflammatory efficacy of a novel hydrogen sulphide‐releasing derivative of naproxen, ATB‐346 [2‐(6‐methoxy‐napthalen‐2‐yl)‐propionic acid 4‐thiocarbamoyl‐phenyl ester]| File | Dimensione | Formato | |
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