RET is the receptor for glial-derived neurotrophic factor growth factors. It is a paradigm of a single gene that causes different types of human cancer when targeted by different genetic alterations. Like other receptor tyrosine kinases, once activated, RET recruits a variety of signaling molecules that mediate biological responses. Here we review data on the signaling pathways that lead to RET-mediated cell transformation and recent evidence that manipulation of RET holds promise for thyroid cancer treatment.
Dysfunction of the RET receptor in human cancer / Santoro, Massimo; Carlomagno, Francesca; Melillo, ROSA MARINA; Fusco, Alfredo. - In: CELLULAR AND MOLECULAR LIFE SCIENCES. - ISSN 1420-682X. - STAMPA. - 61:(2004), pp. 2954-2964. [10.1007/s00018-004-4276-8]
Dysfunction of the RET receptor in human cancer
SANTORO, MASSIMO;CARLOMAGNO, Francesca;MELILLO, ROSA MARINA;FUSCO, ALFREDO
2004
Abstract
RET is the receptor for glial-derived neurotrophic factor growth factors. It is a paradigm of a single gene that causes different types of human cancer when targeted by different genetic alterations. Like other receptor tyrosine kinases, once activated, RET recruits a variety of signaling molecules that mediate biological responses. Here we review data on the signaling pathways that lead to RET-mediated cell transformation and recent evidence that manipulation of RET holds promise for thyroid cancer treatment.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
