The RET gene encodes a single-pass transmembrane receptor tyrosine kinase. RET is the oncogene that causes papillary thyroid carcinoma and medullary thyroid carcinoma. The latter may arise as a component of multiple endocrine neoplasia type 2 syndromes; germline mutations in RET are responsible for multiple endocrine neoplasia type 2 inheritance. In this report we review data on the mechanisms leading to RET oncogenic conversion and on RET targeting as a strategy in thyroid cancer treatment.
Minireview:RET:normal and abnormal functions / Santoro, Massimo; Melillo, ROSA MARINA; Carlomagno, Francesca; Vecchio, Giancarlo; Fusco, Alfredo. - In: ENDOCRINOLOGY. - ISSN 0013-7227. - STAMPA. - 145:(2004), pp. 5448-5451. [10.1210/en.2004-0922]
Minireview:RET:normal and abnormal functions
SANTORO, MASSIMO;MELILLO, ROSA MARINA;CARLOMAGNO, Francesca;VECCHIO, GIANCARLO;FUSCO, ALFREDO
2004
Abstract
The RET gene encodes a single-pass transmembrane receptor tyrosine kinase. RET is the oncogene that causes papillary thyroid carcinoma and medullary thyroid carcinoma. The latter may arise as a component of multiple endocrine neoplasia type 2 syndromes; germline mutations in RET are responsible for multiple endocrine neoplasia type 2 inheritance. In this report we review data on the mechanisms leading to RET oncogenic conversion and on RET targeting as a strategy in thyroid cancer treatment.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
