IRIS
DE SIMONE, Alfonso
 Distribuzione geografica
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Continente #
AS - Asia 3.050
NA - Nord America 1.770
EU - Europa 1.721
SA - Sud America 450
AF - Africa 62
OC - Oceania 3
Continente sconosciuto - Info sul continente non disponibili 1
Totale 7.057
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Nazione #
SG - Singapore 1.825
US - Stati Uniti d'America 1.692
RU - Federazione Russa 1.020
CN - Cina 499
HK - Hong Kong 366
BR - Brasile 359
IT - Italia 289
VN - Vietnam 176
DE - Germania 122
FI - Finlandia 62
GB - Regno Unito 46
KR - Corea 42
FR - Francia 38
AR - Argentina 32
MX - Messico 29
IN - India 28
CA - Canada 26
SE - Svezia 24
BD - Bangladesh 20
AT - Austria 19
JP - Giappone 19
PL - Polonia 19
NL - Olanda 18
EC - Ecuador 17
VE - Venezuela 10
ZA - Sudafrica 10
IQ - Iraq 9
MA - Marocco 9
PY - Paraguay 9
AE - Emirati Arabi Uniti 8
DZ - Algeria 8
ID - Indonesia 8
KE - Kenya 7
ES - Italia 6
PK - Pakistan 6
CL - Cile 5
CO - Colombia 5
LT - Lituania 5
NP - Nepal 5
RO - Romania 5
TR - Turchia 5
UA - Ucraina 5
UZ - Uzbekistan 5
BE - Belgio 4
CI - Costa d'Avorio 4
DO - Repubblica Dominicana 4
HN - Honduras 4
IE - Irlanda 4
JM - Giamaica 4
PE - Perù 4
PH - Filippine 4
SI - Slovenia 4
TN - Tunisia 4
BB - Barbados 3
BG - Bulgaria 3
BO - Bolivia 3
BY - Bielorussia 3
CZ - Repubblica Ceca 3
EG - Egitto 3
GR - Grecia 3
KZ - Kazakistan 3
SA - Arabia Saudita 3
UY - Uruguay 3
AM - Armenia 2
AU - Australia 2
AZ - Azerbaigian 2
BA - Bosnia-Erzegovina 2
CH - Svizzera 2
CR - Costa Rica 2
GY - Guiana 2
HU - Ungheria 2
JO - Giordania 2
ME - Montenegro 2
MR - Mauritania 2
PS - Palestinian Territory 2
SK - Slovacchia (Repubblica Slovacca) 2
SN - Senegal 2
AL - Albania 1
BH - Bahrain 1
BJ - Benin 1
BW - Botswana 1
CG - Congo 1
CY - Cipro 1
DJ - Gibuti 1
DK - Danimarca 1
DM - Dominica 1
EE - Estonia 1
EU - Europa 1
GE - Georgia 1
GF - Guiana Francese 1
GH - Ghana 1
GM - Gambi 1
GN - Guinea 1
HR - Croazia 1
IL - Israele 1
IS - Islanda 1
KH - Cambogia 1
KN - Saint Kitts e Nevis 1
KW - Kuwait 1
LA - Repubblica Popolare Democratica del Laos 1
Totale 7.038
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Città #
Singapore 798
Hong Kong 365
Moscow 284
Santa Clara 250
Hefei 233
Millbury 139
Naples 120
Ashburn 115
Beijing 107
Lawrence 105
Chandler 103
Des Moines 78
Ho Chi Minh City 71
Los Angeles 62
Redondo Beach 54
Helsinki 51
Buffalo 45
Seoul 41
Seattle 38
Hanoi 34
São Paulo 33
The Dalles 33
Wilmington 33
Dallas 22
Falkenstein 22
Napoli 21
Chicago 20
Nuremberg 20
Belo Horizonte 18
Frankfurt am Main 18
Fairfield 17
Rio de Janeiro 14
Rome 14
Munich 13
New York 13
Woodbridge 12
Bologna 11
Boston 11
Florence 11
Mexico City 11
Tokyo 11
Warsaw 10
Da Nang 9
Lappeenranta 9
Haiphong 8
Montreal 8
Toronto 8
Wroclaw 8
Brooklyn 7
Denver 7
Düsseldorf 7
Nairobi 7
Nanjing 7
Porto Alegre 7
San Gennaro Vesuviano 7
Vienna 7
Atlanta 6
Cambridge 6
Chennai 6
Evanston 6
Kronberg 6
Phoenix 6
Rockville 6
Amsterdam 5
Asunción 5
Campinas 5
Manchester 5
Mumbai 5
Orem 5
Parma 5
Recife 5
Salt Lake City 5
São Bernardo do Campo 5
Tashkent 5
Bacoli 4
Bogotá 4
Bracciano 4
Brasília 4
Brussels 4
Campo Grande 4
Caracas 4
Dhaka 4
Dubai 4
Goiânia 4
Guangzhou 4
Johannesburg 4
Karlsruhe 4
Kawasaki 4
Lauterbourg 4
London 4
Norwalk 4
Quito 4
Redwood City 4
San Francisco 4
Santo André 4
Scuola 4
Stockholm 4
Torino 4
Xian 4
Šentjernej 4
Totale 3.788
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Nome #
Artificial heme-enzymes for the construction of functional nanomaterials 131
Classification of metal site coordination number and geometry through artificial neural networks 115
Membrane Interactions and Toxicity by Misfolded Protein Oligomers 114
α-Synuclein and Mitochondria: Probing the Dynamics of Disordered Membrane-protein Regions Using Solid-State Nuclear Magnetic Resonance 103
Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease 94
The role of structural dynamics in the thermal adaptation of hyperthermophilic enzymes 94
Prion and water: Tight and dynamical hydration sites have a key role in structural stability 93
Intrinsic structural versatility of the highly conserved 412–423 epitope of the Hepatitis C Virus E2 protein 90
Blocking von Willebrand factor free thiols inhibits binding to collagen under high and pathological shear stress 87
Structural basis of membrane disruption and cellular toxicity by a-synuclein oligomers 87
Conformational modifications of gB from Herpes simplex virus type 1 analyzed by synthetic peptides 85
Backbone NMR assignments of HypF-N under conditions generating toxic and non-toxic oligomers 85
α-Synuclein and biological membranes: the danger of loving too much 82
Structural differences between toxic and nontoxic HypF-N oligomers 82
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction 82
Catalytic Nanomaterials by Conjugation of an Artificial Heme-Peroxidase to Amyloid Fibrils 78
Molecular determinants of the interaction of EGCG with ordered and disordered proteins 78
Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies 77
Modeling Parkinson’s disease neuropathology and symptoms by intranigral inoculation of preformed human α-synuclein oligomers 76
A Role of Cholesterol in Modulating the Binding of α-Synuclein to Synaptic-Like Vesicles 76
Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide 75
Region-specific changes in gene expression are associated with cognitive deficits in the alpha-synuclein-induced model of Parkinson's disease: A transcriptomic profiling study 74
MetalHawk: Enhanced Classification of Metal Coordination Geometries by Artificial Neural Networks 74
A structural overview of mycobacterial adhesins: Key biomarkers for diagnostics and therapeutics 74
Backbone NMR assignments of the C-terminal domain of the human prion protein and its disease-associated T183A variant 73
Accurate random coil chemical shifts from an analysis of loop regions in native states of proteins 73
Structural Basis for Natural Product Selection and Export by Bacterial ABC Transporters 73
Order and disorder in the physiological membrane binding of α-synuclein 73
Molecular determinants of inactivation of the resuscitation promoting factor B from Mycobacterium tuberculosis 72
In silico study of the mechanism of binding of the N-terminal region of α synuclein to synaptic-like membranes 71
Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca2+ and phosphorylation 70
The Toxicity of Misfolded Protein Oligomers Is Independent of Their Secondary Structure 70
Characterization of the conformational equilibrium between the two major substates of RNase a using NMR chemical shifts 69
Glucokinase gene mutations: Structural and genotype-phenotype analyses in MODY children from South Italy 69
Water molecules as structural determinants among prions of low sequence identity 69
Demonstration of Binding Induced Structural Plasticity in a SH2 Domain 69
Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis 68
Structural and Dynamic properties of incomplete immunoglobulin-like fold domains 67
Local structural motifs in proteins: Detection and characterization of fragments inserted in helices 67
A Carboxylate to Amide Substitution That Switches Protein Folds 67
Cryptic binding properties of a transient folding intermediate in a PDZ tandem repeat 66
Structure and dynamics of the multi-domain resuscitation promoting factor RpfB from Mycobacterium tuberculosis 66
Cavitation energies can outperform dispersion interactions 66
Metal interactions of α-synuclein probed by NMR amide-proton exchange 65
Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity 65
1H, 13C and 15N resonance assignments of human muscle acylphosphatase 65
The crystal structure of the streptococcal collagen-like protein 2 globular domain from invasive M3-type group a streptococcus shows significant similarity to immunomodulatory HIV protein gp41 63
Correlation between ω and ψ dihedral angles in protein structures 63
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates 61
Conformational recognition of an intrinsically disordered protein 61
A kink in DWORF helical structure controls the activation of the sarcoplasmic reticulum Ca2+-ATPase 60
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease 59
Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour 59
The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition 59
Characterization of the Conformational Fluctuations in the Josephin Domain of Ataxin-3 58
Carbohydrate recognition by RpfB from mycobacterium tuberculosis unveiled by crystallographic and molecular dynamics analyses 58
The structure of Resuscitation promoting factor B from M. tuberculosis reveals unexpected ubiquitin-like domains 58
Immune responses to oligomeric α-synuclein in Parkinson's disease peripheral blood mononuclear cells 57
Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity 57
Desolvation of the substrate-binding protein TauA dictates ligand specificity for the alkanesulfonate ABC importer TauABC 56
Editorial: Oligomers in amyloid-associated diseases-structural properties and toxicity 55
Repurposing Pomalidomide as a Neuroprotective Drug: Efficacy in an Alpha-Synuclein-Based Model of Parkinson’s Disease 55
Structural basis of synaptic vesicle assembly promoted by α-synuclein 55
Thermal tuning of protein hydration in a hyperthermophilic enzyme 54
Protein kinase R dependent phosphorylation of α-synuclein regulates its membrane binding and aggregation 53
Plasticity of Membrane Binding by the Central Region of α-Synuclein 53
The Intranigral Infusion of Human-Alpha Synuclein Oligomers Induces a Cognitive Impairment in Rats Associated with Changes in Neuronal Firing and Neuroinflammation in the Anterior Cingulate Cortex 52
Advances in modelling alpha-synuclein-induced Parkinson's diseases in rodents: Virus-based models versus inoculation of exogenous preformed toxic species 52
Biochemical and biophysical comparison of human and mouse beta-2 microglobulin reveals the molecular determinants of low amyloid propensity 51
Characterizing protein crystal contacts and their role in crystallization: Rubredoxin as a case study 50
The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State 49
Atomic structure and hierarchical assembly of a cross-β amyloid fibril 47
Accurate Determination of Conformational Transitions in Oligomeric Membrane Proteins 46
Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies 45
Structural and hydration properties of the partially unfolded states of the prion protein 44
Enhancing Biomolecular Simulations with Hybrid Potentials Incorporating NMR Data 43
Characterizing intermolecular interactions that initiate native-like protein aggregation 43
Structure-Free Validation of Residual Dipolar Coupling and Paramagnetic Relaxation Enhancement Measurements of Disordered Proteins 41
Structure, dynamics, and stability of assemblies of the human prion fragment SNQNNF 41
Under the Influence of Water: Molecular Recognition of Organic Hydrophilic Molecules in Water with a Prismarene Host Driven by Hydration Effects 40
Toward an accurate determination of free energy landscapes in solution states of proteins 39
Determination of conformational equilibria in proteins using residual dipolar couplings 39
New opportunities for tensor-free calculations of residual dipolar couplings for the study of protein dynamics 38
Cucurbit[8]uril and blue-box: High-energy water release overwhelms electrostatic interactions 38
Toward understanding the molecular bases of stretch activation: A structural comparison of the two troponin C isoforms of Lethocerus 38
Role of hydration in collagen recognition by bacterial adhesins 38
Substitutions at residue 211 in the prion protein drive a switch between CJD and GSS syndrome, a new mechanism governing inherited neurodegenerative disorders 38
The PROSECCO server for chemical shift predictions in ordered and disordered proteins 38
Characterization of the interdomain motions in hen lysozyme using residual dipolar couplings as replica-averaged structural restraints in molecular dynamics simulations 37
Intrinsic disorder modulates protein self-assembly and aggregation 37
Toward the understanding of MNEI sweetness from hydration map surfaces 37
Probing the dynamic stalk region of the ribosome using solution NMR 37
Mechanism of misfolding of the human prion protein revealed by a pathological mutation 37
Dynamical properties of steric zipper polymorphs formed by a IAPP-derived peptide 36
Twisting transition between crystalline and fibrillar phases of aggregated peptides 36
The Josephin domain determines the morphological and mechanical properties of ataxin-3 fibrils 35
Determination of secondary structure populations in disordered states of proteins using nuclear magnetic resonance chemical shifts 34
Determination of structural fluctuations of proteins from structure-based calculations of residual dipolar couplings 34
The intrinsic stability of the human prion β-sheet region investigated by molecular dynamics 34
Role of side chains in collagen triple helix stabilization and partner recognition 33
Totale 6.150
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Categoria #
all - tutte 27.295
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 27.295
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021210 0 0 0 0 0 0 19 151 29 1 5 5
2021/2022328 11 9 1 1 9 10 4 25 12 1 16 229
2022/2023449 155 29 12 11 37 39 1 65 67 5 24 4
2023/2024387 21 34 39 18 19 14 6 45 7 8 120 56
2024/20252.812 162 123 28 33 126 229 300 195 237 267 857 255
2025/20263.037 511 482 488 482 975 99 0 0 0 0 0 0
Totale 7.230