DE SIMONE, Alfonso

DE SIMONE, Alfonso  

DIPARTIMENTO DI FARMACIA  

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Structural differences between toxic and nontoxic HypF-N oligomers 1.1 Articolo in rivista 2018 Capitini, Claudia; Patel, Jayneil R.; Natalello, Antonino; D'Andrea, Cristiano; Relini, Annalisa; Jarvis, James A.; Birolo, Leila; Peduzzo, Alessia; Vendruscolo, Michele; Matteini, Paolo; Dobson, Christopher M.; De Simone, Alfonso; Chiti, Fabrizio
Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity 1.1 Articolo in rivista 2020 Stephens, A. D.; Zacharopoulou, M.; Moons, R.; Fusco, G.; Seetaloo, N.; Chiki, A.; Woodhams, P. J.; Mela, I.; Lashuel, H. A.; Phillips, J. J.; De Simone, A.; Sobott, F.; Schierle, G. S. K.
Modeling Parkinson’s disease neuropathology and symptoms by intranigral inoculation of preformed human α-synuclein oligomers 1.1 Articolo in rivista 2020 Boi, L.; Pisanu, A.; Palmas, M. F.; Fusco, G.; Carboni, E.; Casu, M. A.; Satta, V.; Scherma, M.; Janda, E.; Mocci, I.; Mulas, G.; Ena, A.; Spiga, S.; Fadda, P.; De Simone, A.; Carta, A. R.
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease 1.1 Articolo in rivista 2020 Heller, G. T.; Aprile, F. A.; Michaels, T. C. T.; Limbocker, R.; Perni, M.; Ruggeri, F. S.; Mannini, B.; Lohr, T.; Bonomi, M.; Camilloni, C.; de Simone, A.; Felli, I. C.; Pierattelli, R.; Knowles, T. P. J.; Dobson, C. M.; Vendruscolo, M.
Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies 1.1 Articolo in rivista 2019 Cascella, R.; Perni, M.; Chen, S. W.; Fusco, G.; Cecchi, C.; Vendruscolo, M.; Chiti, F.; Dobson, C. M.; De Simone, A.
In silico study of the mechanism of binding of the N-terminal region of α synuclein to synaptic-like membranes 1.1 Articolo in rivista 2020 Navarro-Paya, C.; Sanz-Hernandez, M.; De Simone, A.
Molecular determinants of the interaction of EGCG with ordered and disordered proteins 1.1 Articolo in rivista 2018 Fusco, G.; Sanz-Hernandez, M.; Ruggeri, F. S.; Vendruscolo, M.; Dobson, C. M.; De Simone, A.
Prion and water: Tight and dynamical hydration sites have a key role in structural stability 1.1 Articolo in rivista 2005 De Simone, A.; Dodson, G. G.; Verma, C. S.; Zagari, A.; Fraternali, F.
Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide 1.1 Articolo in rivista 2017 Heller, G. T.; Aprile, F. A.; Bonomi, M.; Camilloni, C.; De Simone, A.; Vendruscolo, M.
Water molecules as structural determinants among prions of low sequence identity 1.1 Articolo in rivista 2006 De Simone, A.; Dodson, G. G.; Fraternali, F.; Zagari, A.
Structural basis of membrane disruption and cellular toxicity by a-synuclein oligomers 1.1 Articolo in rivista 2017 Fusco, G.; Chen, S. W.; Williamson, P. T. F.; Cascella, R.; Perni, M.; Jarvis, J. A.; Cecchi, C.; Vendruscolo, M.; Chiti, F.; Cremades, N.; Ying, L.; Dobson, C. M.; De Simone, A.
Blocking von Willebrand factor free thiols inhibits binding to collagen under high and pathological shear stress 1.1 Articolo in rivista 2021 O'Brien, H. E. R.; Zhang, X. F.; Sanz-Hernandez, M.; Chion, A.; Shapiro, S.; Mobayen, G.; Xu, Y.; De Simone, A.; Laffan, M. A.; Mckinnon, T. A. J.
Demonstration of Binding Induced Structural Plasticity in a SH2 Domain 1.1 Articolo in rivista 2020 Visconti, L.; Toto, A.; Jarvis, J. A.; Troilo, F.; Malagrino, F.; De Simone, A.; Gianni, S.
A structural overview of mycobacterial adhesins: Key biomarkers for diagnostics and therapeutics 1.1 Articolo in rivista 2018 Squeglia, F.; Ruggiero, A.; De Simone, A.; Berisio, R.
Intrinsic structural versatility of the highly conserved 412–423 epitope of the Hepatitis C Virus E2 protein 1.1 Articolo in rivista 2018 Balasco, N.; Barone, D.; Iaccarino, E.; Sandomenico, A.; De Simone, A.; Ruvo, M.; Vitagliano, L.
Local structural motifs in proteins: Detection and characterization of fragments inserted in helices 1.1 Articolo in rivista 2018 Balasco, N.; Smaldone, G.; Ruggiero, A.; De Simone, A.; Vitagliano, L.
Structural Basis for Natural Product Selection and Export by Bacterial ABC Transporters 1.1 Articolo in rivista 2018 Romano, M.; Fusco, G.; Choudhury, H. G.; Mehmood, S.; Robinson, C. V.; Zirah, S.; Hegemann, J. D.; Lescop, E.; Marahiel, M. A.; Rebuffat, S.; De Simone, A.; Beis, K.
The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State 1.1 Articolo in rivista 2020 Runfola, M.; De Simone, A.; Vendruscolo, M.; Dobson, C. M.; Fusco, G.
Backbone NMR assignments of HypF-N under conditions generating toxic and non-toxic oligomers 1.1 Articolo in rivista 2018 Patel, J. R.; Xu, Y.; Capitini, C.; Chiti, F.; De Simone, A.
A Role of Cholesterol in Modulating the Binding of α-Synuclein to Synaptic-Like Vesicles 1.1 Articolo in rivista 2020 Man, W. K.; De Simone, A.; Barritt, J. D.; Vendruscolo, M.; Dobson, C. M.; Fusco, G.