IRIS
LA PIETRA, VALERIA
 Distribuzione geografica
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Continente #
AS - Asia 1.645
EU - Europa 1.376
NA - Nord America 1.253
SA - Sud America 241
AF - Africa 57
Continente sconosciuto - Info sul continente non disponibili 1
Totale 4.573
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Nazione #
US - Stati Uniti d'America 1.198
SG - Singapore 868
RU - Federazione Russa 685
CN - Cina 405
IT - Italia 319
BR - Brasile 194
HK - Hong Kong 132
VN - Vietnam 111
DE - Germania 80
NL - Olanda 69
FI - Finlandia 65
IE - Irlanda 46
IN - India 34
CA - Canada 30
CI - Costa d'Avorio 29
GB - Regno Unito 28
AR - Argentina 23
FR - Francia 22
MX - Messico 18
KR - Corea 16
JP - Giappone 14
PL - Polonia 14
TR - Turchia 12
IQ - Iraq 11
BD - Bangladesh 10
EC - Ecuador 9
AT - Austria 7
SE - Svezia 7
ZA - Sudafrica 7
IR - Iran 6
UA - Ucraina 6
ID - Indonesia 5
BE - Belgio 4
ES - Italia 4
LT - Lituania 4
MA - Marocco 4
PY - Paraguay 4
AE - Emirati Arabi Uniti 3
AZ - Azerbaigian 3
ET - Etiopia 3
PE - Perù 3
UZ - Uzbekistan 3
VE - Venezuela 3
CL - Cile 2
EE - Estonia 2
EG - Egitto 2
GF - Guiana Francese 2
HU - Ungheria 2
IL - Israele 2
JM - Giamaica 2
LU - Lussemburgo 2
NE - Niger 2
PA - Panama 2
AL - Albania 1
BN - Brunei Darussalam 1
CG - Congo 1
CO - Colombia 1
CR - Costa Rica 1
CZ - Repubblica Ceca 1
DO - Repubblica Dominicana 1
DZ - Algeria 1
EU - Europa 1
GA - Gabon 1
GE - Georgia 1
GH - Ghana 1
GN - Guinea 1
GR - Grecia 1
HN - Honduras 1
IS - Islanda 1
JO - Giordania 1
KH - Cambogia 1
LB - Libano 1
LV - Lettonia 1
MD - Moldavia 1
MK - Macedonia 1
MN - Mongolia 1
NG - Nigeria 1
NO - Norvegia 1
PH - Filippine 1
PK - Pakistan 1
RO - Romania 1
SD - Sudan 1
SK - Slovacchia (Repubblica Slovacca) 1
SY - Repubblica araba siriana 1
TH - Thailandia 1
TN - Tunisia 1
ZM - Zambia 1
ZW - Zimbabwe 1
Totale 4.573
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Città #
Singapore 405
Moscow 163
Chandler 151
Beijing 142
Hong Kong 132
Ashburn 110
Santa Clara 92
Naples 89
Dallas 86
Hefei 80
Amsterdam 61
Millbury 44
San Jose 43
Napoli 41
Los Angeles 37
Ho Chi Minh City 36
Princeton 33
Nanjing 31
Munich 28
Hanoi 24
The Dalles 24
Des Moines 23
Ottawa 20
Redondo Beach 20
Boston 19
Buffalo 17
Chicago 17
Düsseldorf 16
Rome 16
Turku 16
São Paulo 15
Seoul 14
Seattle 12
Tokyo 12
Warsaw 12
Mexico City 11
New York 11
Frankfurt am Main 10
Milan 10
Wilmington 10
Augusta 9
Brooklyn 9
Falkenstein 9
Helsinki 9
Kochi 9
Lappeenranta 9
Bagnoli Irpino 8
Dong Ket 8
Hebei 8
Lawrence 8
Nanchang 8
Santa Maria Capua Vetere 8
Shenyang 8
Bologna 7
Houston 7
Nuremberg 7
Secaucus 7
Ankara 6
Changsha 6
Rio de Janeiro 6
San Mateo 6
Tianjin 6
Dearborn 5
Stockholm 5
Toronto 5
Baghdad 4
Belo Horizonte 4
Chennai 4
Council Bluffs 4
Denver 4
Filottrano 4
Hải Dương 4
Jiaxing 4
Orem 4
Quận Bình Thạnh 4
Reggio Emilia 4
Vienna 4
Asunción 3
Atlanta 3
Brussels 3
Bắc Giang 3
Can Tho 3
Caserta 3
Charlotte 3
Curitiba 3
Da Nang 3
Dublin 3
Guangzhou 3
Guayaquil 3
Ha Long 3
Hangzhou 3
Jacksonville 3
Johannesburg 3
Lauterbourg 3
London 3
Mateus Leme 3
Orta di Atella 3
Pisa 3
Poplar 3
Portsmouth 3
Totale 2.433
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Nome #
A reverse translational approach reveals the protective roles of Mangifera indica in inflammatory bowel disease 160
Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity 156
Interfering with the Tumor-Immune Interface: Making Way for Triazine-Based Small Molecules as Novel PD-L1 Inhibitors 142
Development and Nanoparticle-Mediated Delivery of Novel MDM2/MDM4 Heterodimer Peptide Inhibitors to Enhance 5-Fluorouracil Nucleolar Stress in Colorectal Cancer Cells 132
Exploring the N-Terminal Region of C-X-C Motif Chemokine 12 (CXCL12): Identification of Plasma-Stable Cyclic Peptides As Novel, Potent C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonists 129
Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design 127
Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents 116
A combined approach of structure‐based virtual screening and NMR to interrupt the PD‐1/PD‐L1 axis: Biphenyl‐benzimidazole containing compounds as novel PD‐L1 inhibitors 110
State-of-the-art methodologies for the discovery and characterization of DNA G-Quadruplex binders 109
A more detailed picture of the interactions between Virtual Screening-derived Hits and the DNA G-Quadruplex: NMR, Molecular Modeling and ITC Studies 109
Progresses in the pursuit of aldose reductase inhibitors: the structure-based lead optimization step. 107
Enriching the arsenal of pharmacological tools against mical2 107
A more detailed picture of the interactions between virtual screening-derived hits and the DNA G-quadruplex: NMR, molecular modelling and ITC studies. 106
Identification of a Novel p53 Modulator Endowed with Antitumoural and Antibacterial Activity through a Scaffold Repurposing Approach 103
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 101
Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme 100
MDM2/4 inhibitors as novel therapeutic strategy to enhance 5-FU induced nucleolar stress and apoptosis in colon cancer cells 98
Long lasting inhibition of Mdm2-p53 interaction potentiates mesenchymal stem cell differentiation into osteoblasts 97
Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent to Combat Alzheimer's Disease 95
Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis 95
A stereoselective approach to peptidomimetic BACE1 inhibitors 94
Bax Activation Blocks Self-Renewal and Induces Apoptosis of Human Glioblastoma Stem Cells 93
Design, Synthesis, and Biological Evaluation of 1-Phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as New Glycogen Synthase Kinase-3 beta Inhibitors 88
Best Matching Protein Conformations and Docking Programs for a Virtual Screening Campaign Against SMO Receptor 88
Protective effects of olive oil antioxidant phenols on mercury-induced phosphatidylserine externalization in erythrocyte membrane: Insights into scramblase and flippase activity 87
Challenging clinically unresponsive medullary thyroid cancer: Discovery and pharmacological activity of novel RET inhibitors 87
Human recombinant beta-secretase immobilized enzyme reactor for fast hits' selection and characterization from a virtual screening library 85
N-O-ISOPROPYL SULFONAMIDO-BASED HYDROXAMATES: KINETIC CHARACTERISATION OF A SERIES OF MMP-12/MMP-13 DUAL TARGET INHIBITORS. 85
Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: A first round of lead optimization. 84
Discovery of Covalent Inhibitors of Glyceraldehyde-3-phosphate Dehydrogenase, A Target for the Treatment of Malaria 84
Combination of 5-FU and MDM2/4 peptide inhibitors as a promising strategy to enhance 5-FU induced nucleolar stress. 83
Enhanced 5-FU-mediated activation of p53-dependent nucleolar stress by MDM2/4 peptide inhibitors in colon cancer cells 83
Protein Flexibility in Virtual Screening: The BACE-1 Case Study 83
CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme 81
Structure-Based Optimization of Tyrosine Kinase InhibitorCLM3. Design, Synthesis, Functional Evaluation, and Molecular Modeling Studies. 76
Site-directed Mutagenesis of Key Residues Unveiled a Novel Allosteric Site on Human Adenosine Kinase for Pyrrolobenzoxa(thia)zepinone Non-Nucleoside Inhibitors 76
Selective Arylsulfonamide Inhibitors of ADAM-17: Hit Optimization and Activity in Ovarian Cancer Cell Models 75
Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas 75
Receptor-bound conformation of cilengitide better represented by its solution-state structure than the solid-state structure 70
Benzothiopyranoindole- and pyridothiopyranoindole-based antiproliferative agents targeting topoisomerases 69
Potent Arylsulfonamide Inhibitors of Tumor Necrosis Factor-alfa Converting Enzyme Able to Reduce Activated Leukocyte Cell Adhesion Molecule Shedding in Cancer Cell Models 65
Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies. 62
Apoptosis Therapy in Cancer: The First Single-molecule Co-activating p53 and the Translocator Protein in Glioblastoma 62
Development of novel dipeptide-like rhodesain inhibitors containing the 3-bromoisoxazoline warhead in a constrained conformation 62
Identification of Glycogen Synthase Kinase-3 Inhibitors with a Selective Sting for Glycogen Synthase Kinase-3α 61
HuR modulation counteracts lipopolysaccharide response in murine macrophages 58
HuR-targeted agents: An insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models 57
Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: Synthesis and biological evaluation 54
p53 Functional Inhibitors Behaving Like Pifithrin-? Counteract the Alzheimer Peptide Non-?-amyloid Component Effects in Human SH-SY5Y Cells 52
A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach 51
Editorial: Promising tools in targeted cancer therapy 50
Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors. 48
Novel, soluble 3-heteroaryl-substituted tanshinone mimics attenuate the inflammatory response in murine macrophages 43
N-O-Isopropyl Sulfonamido-Based Hydroxamates: Design, Synthesis and Biological Evaluation of Selective Matrix Metalloproteinase-13 Inhibitors as Potential Therapeutic Agents for Osteoarthritis 43
Totale 4.713
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Categoria #
all - tutte 15.535
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 15.535
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202161 0 0 0 0 0 0 2 10 13 1 25 10
2021/2022226 3 2 4 1 4 1 0 12 51 36 22 90
2022/2023360 41 15 13 34 40 44 0 28 55 58 27 5
2023/2024258 24 26 34 23 18 23 11 34 1 3 43 18
2024/20251.583 66 93 4 38 27 133 172 136 91 153 542 128
2025/20261.860 311 235 378 254 498 106 78 0 0 0 0 0
Totale 4.713