Background: Curcumin is a polyphenolic compound present in turmeric (Curcuma longa). Curcumin, turmeric powder, and extracts are widely used in traditional Indian medicine and are active ingredients of dietary supplements and cosmeceutical products. The pharmacological properties of curcumin/turmeric as well as the studies performed in vitro, in animal models, and in volunteers have been the objects of a vast literature. Most of the clinical studies report on the effects of curcumin/turmeric administered orally, while only a few describe its topical applications. Summary: This review focuses on clinical studies in which curcumin/turmeric was applied topically to treat various skin conditions based on its antioxidant, anti-inflammatory, and antimicrobial properties. Key Messages: The clinical studies employing curcumin/turmeric as the only active ingredient allow us to appreciate its therapeutic potential without confounding contributions coming from additional pharmacologically active substances present in the same formulation. Curcumin/turmeric was regarded as an attractive alternative to conventional drugs, such as corticosteroids and antibiotics, thanks to its characteristics of a safe and well-tolerated natural substance.

Clinical studies on topical Curcumin / DI LORENZO, Ritamaria; Forgione, Federica; Bernardi, Antonietta; Sacchi, Antonia; Laneri, Sonia; Greco, Giovanni. - In: SKIN PHARMACOLOGY AND PHYSIOLOGY. - ISSN 1660-5527. - 36:5(2024), pp. 235-248. [10.1159/000535100]

Clinical studies on topical Curcumin

Di Lorenzo Ritamaria
Primo
;
Forgione Federica;Bernardi Antonietta;Antonia Sacchi;Sonia Laneri
;
Giovanni Greco
Ultimo
2024

Abstract

Background: Curcumin is a polyphenolic compound present in turmeric (Curcuma longa). Curcumin, turmeric powder, and extracts are widely used in traditional Indian medicine and are active ingredients of dietary supplements and cosmeceutical products. The pharmacological properties of curcumin/turmeric as well as the studies performed in vitro, in animal models, and in volunteers have been the objects of a vast literature. Most of the clinical studies report on the effects of curcumin/turmeric administered orally, while only a few describe its topical applications. Summary: This review focuses on clinical studies in which curcumin/turmeric was applied topically to treat various skin conditions based on its antioxidant, anti-inflammatory, and antimicrobial properties. Key Messages: The clinical studies employing curcumin/turmeric as the only active ingredient allow us to appreciate its therapeutic potential without confounding contributions coming from additional pharmacologically active substances present in the same formulation. Curcumin/turmeric was regarded as an attractive alternative to conventional drugs, such as corticosteroids and antibiotics, thanks to its characteristics of a safe and well-tolerated natural substance.
2024
Clinical studies on topical Curcumin / DI LORENZO, Ritamaria; Forgione, Federica; Bernardi, Antonietta; Sacchi, Antonia; Laneri, Sonia; Greco, Giovanni. - In: SKIN PHARMACOLOGY AND PHYSIOLOGY. - ISSN 1660-5527. - 36:5(2024), pp. 235-248. [10.1159/000535100]
File in questo prodotto:
File Dimensione Formato  
Di Lorenzo Skin Pharm and Physio 2024.pdf

accesso aperto

Tipologia: Versione Editoriale (PDF)
Licenza: Dominio pubblico
Dimensione 349.45 kB
Formato Adobe PDF
349.45 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/953510
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 5
social impact