Arginase is a manganese-containing enzyme performing the chemical change of l-arginine to urea and ornithine. Because of arginine’s role as a central metabolic player, arginase has become a primary ongoing research target with multiple roles in human health and disease. In this chapter, I discuss the structural details of the enzyme, and how structural biology is shaping the development of arginase small-molecule inhibitors and inhibitor-antibodies. These studies represent the foundation of arginase for therapeutic strategies in many areas of medicine ranging from immune response and aging to oncology.
The role of arginase in human health and disease / Costanzo, Di. - (2023), pp. 333-342. [10.1016/B978-0-12-823974-2.00008-5]
The role of arginase in human health and disease
DI COSTANZO
Conceptualization
2023
Abstract
Arginase is a manganese-containing enzyme performing the chemical change of l-arginine to urea and ornithine. Because of arginine’s role as a central metabolic player, arginase has become a primary ongoing research target with multiple roles in human health and disease. In this chapter, I discuss the structural details of the enzyme, and how structural biology is shaping the development of arginase small-molecule inhibitors and inhibitor-antibodies. These studies represent the foundation of arginase for therapeutic strategies in many areas of medicine ranging from immune response and aging to oncology.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
