56. Towards New Exogenous Antioxidant Supplements organo-Se-based.

Even though oxidative stress (OS), a disequilibrium redox state, is a major risk factors for the development of several medical illnesses, such as cardiovascular disease, age-related neurodegenerative diseases, and several types of cancer, epidemiological studies have shown that eating foods high in antioxidants or using exogenous antioxidant supplementation may help to lower this risk. 1 Nutraceuticals are of particular interest; indeed, they might be used to prevent or mitigate OS by providing other health advantages in addition to nutrition.2 Within this frame of reference, our research is focused on Selenium (Se) and polyphenols. The former is one of the trace elements involved in immunological system, growth, healthy muscular activity, reproductive organs, decreases the toxicity of some elements such as mercury responses and whose deficiency is linked to immune, cardiac, muscular, bone, and other disease. 3 The latter are acknowledged to have health-promoting properties, although their limited bioavailability is frequently blamed. Within this framework of assessing their real potential as an approach to combating diseases, it is well known that glycosylation affects the chemical, biological, and physical characteristics of polyphenols, allowing for greater absorption in the small intestine. 4 Thus, the synthesis of organo-Se-compounds with a sugar-type structure, analogue to arbutin, coupled with (poly)phenols via Mitsunobu reactions aims to provide novel molecules that could overcome limited bioavailability while also providing a synergistic antioxidant effect. 5 DPPH and ABTS antiradical tests were used to evaluate the bioactivity of selenoglycoconjugates. Moreover, the effects on cell proliferation were preliminary investigated towards Caco-2 intestinal epithelial cells, SHSY5Y neuroblastoma cells, and HaCaT keratinocytes. The phenol moiety has a significant impact on both antiradical activity and mitochondrial redox activity. The cytotoxic effects of glycoconjugates, particularly at the highest tested doses, were lower than those of unconjugated phenolic compounds, highlighting the moderating influence of selenosugar.