: Bovine alphaherpesvirus 1 (BoAHV-1), the pathogen causing Infectious Bovine Rhinotracheitis (IBR) and predisposing to polymicrobial infections in cattle, provokes farm economic losses and trading restrictions in the world. However, nontoxic antiviral agents for BoAHV-1 infection are still unavailable, but plant extracts, such as flavonoid derivatives possess activity against BoAHV-1. Taurisolo®, a nutraceutical produced by Aglianico grape pomace, has recently shown promising antiviral activity. Herein, the potential activity of Taurisolo® during BoAHV-1 infection in Madin Darby bovine kidney (MDBK) cells was tested. Taurisolo® enhanced cell viability and reduced morphological death signs in BoAHV-1-infected cells. Moreover, Taurisolo® influenced the expression of bICP0, the key regulatory protein of BoAHV-1, and it strongly diminished virus yield. These effects were associated with an up-regulation of aryl hydrocarbon receptor (AhR), a transcription factor involved in microbial metabolism and immune response. In conclusion, our findings indicate that Taurisolo® may represent a potential antiviral agent against BoAHV-1 infection. Noteworthy, AhR could be involved in the observed effects and become a new target in antiviral therapy.

Antiviral activity of Taurisolo® during bovine alphaherpesvirus 1 infection / Cerracchio, C.; Amoroso, M. G.; Piccolo, M.; Ferraro, M. G.; Nocera, F. P.; De Martino, L.; Serra, F.; Irace, C.; Tenore, G. C.; Novellino, E.; Santamaria, R.; Fiorito, F.. - In: VIRUS RESEARCH. - ISSN 0168-1702. - 336:(2023), p. 199217. [10.1016/j.virusres.2023.199217]

Antiviral activity of Taurisolo® during bovine alphaherpesvirus 1 infection

Cerracchio C.;Amoroso M. G.;Piccolo M.;Ferraro M. G.;Nocera F. P.;Irace C.
;
Tenore G. C.;Novellino E.;
2023

Abstract

: Bovine alphaherpesvirus 1 (BoAHV-1), the pathogen causing Infectious Bovine Rhinotracheitis (IBR) and predisposing to polymicrobial infections in cattle, provokes farm economic losses and trading restrictions in the world. However, nontoxic antiviral agents for BoAHV-1 infection are still unavailable, but plant extracts, such as flavonoid derivatives possess activity against BoAHV-1. Taurisolo®, a nutraceutical produced by Aglianico grape pomace, has recently shown promising antiviral activity. Herein, the potential activity of Taurisolo® during BoAHV-1 infection in Madin Darby bovine kidney (MDBK) cells was tested. Taurisolo® enhanced cell viability and reduced morphological death signs in BoAHV-1-infected cells. Moreover, Taurisolo® influenced the expression of bICP0, the key regulatory protein of BoAHV-1, and it strongly diminished virus yield. These effects were associated with an up-regulation of aryl hydrocarbon receptor (AhR), a transcription factor involved in microbial metabolism and immune response. In conclusion, our findings indicate that Taurisolo® may represent a potential antiviral agent against BoAHV-1 infection. Noteworthy, AhR could be involved in the observed effects and become a new target in antiviral therapy.
2023
Antiviral activity of Taurisolo® during bovine alphaherpesvirus 1 infection / Cerracchio, C.; Amoroso, M. G.; Piccolo, M.; Ferraro, M. G.; Nocera, F. P.; De Martino, L.; Serra, F.; Irace, C.; Tenore, G. C.; Novellino, E.; Santamaria, R.; Fiorito, F.. - In: VIRUS RESEARCH. - ISSN 0168-1702. - 336:(2023), p. 199217. [10.1016/j.virusres.2023.199217]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/941087
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