Polymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term “nanoparticle” stands for both nanocapsules and nanospheres, which are distinguished by the morphological structure. Polymeric NPs have shown great potential for targeted delivery of drugs for the treatment of several diseases. In this review, we discuss the most commonly used methods for the production and characterization of polymeric NPs, the association efficiency of the active compound to the polymeric core, and the in vitro release mechanisms. As the safety of nanoparticles is a high priority, we also discuss the toxicology and ecotoxicology of nanoparticles to humans and to the environment.
Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology / Zieli´nska, Aleksandra; Carreiró, Filipa; Oliveira, Ana M.; Neves, Andreia; Pires, Bárbara; Nagasamy Venkatesh, D.; Durazzo, Alessandra; Lucarini, Massimo; Eder, Piotr; Silva, Amélia M.; Santini, Antonello; Souto, Eliana B.. - In: MOLECULES. - ISSN 1420-3049. - 25(16):3731(2020). [10.3390/molecules25163731]
Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology
Antonello Santini
;
2020
Abstract
Polymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term “nanoparticle” stands for both nanocapsules and nanospheres, which are distinguished by the morphological structure. Polymeric NPs have shown great potential for targeted delivery of drugs for the treatment of several diseases. In this review, we discuss the most commonly used methods for the production and characterization of polymeric NPs, the association efficiency of the active compound to the polymeric core, and the in vitro release mechanisms. As the safety of nanoparticles is a high priority, we also discuss the toxicology and ecotoxicology of nanoparticles to humans and to the environment.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
