Tumor-associated macrophages (TAMs) affect tumor biology and immune escape. TAMs are in constant transition between M1 (anti-tumor) and M2 (pro-tumor) phenotypes because of high plasticity, which requires a fast change of translational activity. FKBP51 is an immunophilin encoded by the FKBP5 gene that supports NF-κB and STAT1 transcriptional activities, essential features of M1 macrophages. FKBP5 alternative splicing occurs on M2 polarization. The splicing protein is unable to support NF-κB and STAT1 activation, but it upregulates PD-L1 expression.
Alternative splicing of the FKBP5 gene drives alternative macrophage polarization / Romano, MARIA FIAMMETTA. - (2022). (Intervento presentato al convegno Festival of Biologics World Immunotherapy Congress tenutosi a Basel nel 2 Novembre).
Alternative splicing of the FKBP5 gene drives alternative macrophage polarization
Maria Fiammetta Romano
2022
Abstract
Tumor-associated macrophages (TAMs) affect tumor biology and immune escape. TAMs are in constant transition between M1 (anti-tumor) and M2 (pro-tumor) phenotypes because of high plasticity, which requires a fast change of translational activity. FKBP51 is an immunophilin encoded by the FKBP5 gene that supports NF-κB and STAT1 transcriptional activities, essential features of M1 macrophages. FKBP5 alternative splicing occurs on M2 polarization. The splicing protein is unable to support NF-κB and STAT1 activation, but it upregulates PD-L1 expression.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
