: The molecular mechanism of how human serum transferrin (hTF) recognizes cisplatin at the atomic level is still unclear. Here, we report the molecular structure of the adduct formed upon the reaction of hTF with cisplatin. Pt binds the side chain of Met256 (at the N-lobe), without altering the protein overall conformation.
Cisplatin Binding to Human Serum Transferrin: A Crystallographic Study / Troisi, R.; Galardo, F.; Ferraro, G.; Sica, F.; Merlino, A.. - In: INORGANIC CHEMISTRY. - ISSN 1520-510X. - 62:2(2023), pp. 675-678. [10.1021/acs.inorgchem.2c04206]
Cisplatin Binding to Human Serum Transferrin: A Crystallographic Study
Troisi R.;Galardo F.;Ferraro G.;Sica F.;Merlino A.
2023
Abstract
: The molecular mechanism of how human serum transferrin (hTF) recognizes cisplatin at the atomic level is still unclear. Here, we report the molecular structure of the adduct formed upon the reaction of hTF with cisplatin. Pt binds the side chain of Met256 (at the N-lobe), without altering the protein overall conformation.File in questo prodotto:
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