This study investigates longitudinal changes in health-related quality of life (HRQoL) in early-onset multiple sclerosis (MS) patients and explores the impact of disease activity (relapses) on such changes. People with MS (PwMS) onset between 12 and 25 years of age were followed longitudinally. At baseline and at year 4, patients were asked to fill the Paediatric Quality of life inventory (PedsQL). Demographic and clinical features were collected at both time points. Longitudinal within-group comparison of HRQoL total score and sub-scores was performed via paired samples t-test. The effect of relapses on the HRQoL changes over time was explored via linear mixed-effects analysis. No longitudinal changes were observed in the overall PedsQL score, nor in the physical, school and psychological functioning. An increase in the social functioning subscale (p < 0.001) and a decrease in the emotional subscale (p = 0.006) were observed. The change in social functioning, but not the one in the emotional subscale, was affected by the occurrence of relapses (p = 0.044). In conclusion, stimulating the patients to accept their emotional responses to health-related limitations, while preserving their social and relational resources seems key to the preservation of an adequate QoL over time in juvenile-onset MS.

Quality of Life Changes in Early-Onset Multiple Sclerosis: A 4-Year Follow-Up Study / Rosa, Laura; Petracca, Maria; Carotenuto, Antonio; Dolce, Pasquale; Piscopo, Kyrie; Dicé, Francesca; Lauro, Francesca; Spiezia, Antonio Luca; Moccia, Marcello; Lavorgna, Luigi; Iacovazzo, Carmine; Servillo, Giuseppe; Maldonato, Nelson Mauro; Chiodi, Alessandro; Brescia Morra, Vincenzo; Lanzillo, Roberta. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 11:17(2022), p. 5226. [10.3390/jcm11175226]

Quality of Life Changes in Early-Onset Multiple Sclerosis: A 4-Year Follow-Up Study

Rosa, Laura;Petracca, Maria;Carotenuto, Antonio;Dolce, Pasquale;Piscopo, Kyrie;Dicé, Francesca;Lauro, Francesca;Spiezia, Antonio Luca;Moccia, Marcello;Iacovazzo, Carmine;Servillo, Giuseppe;Maldonato, Nelson Mauro;Chiodi, Alessandro;Brescia Morra, Vincenzo;Lanzillo, Roberta
2022

Abstract

This study investigates longitudinal changes in health-related quality of life (HRQoL) in early-onset multiple sclerosis (MS) patients and explores the impact of disease activity (relapses) on such changes. People with MS (PwMS) onset between 12 and 25 years of age were followed longitudinally. At baseline and at year 4, patients were asked to fill the Paediatric Quality of life inventory (PedsQL). Demographic and clinical features were collected at both time points. Longitudinal within-group comparison of HRQoL total score and sub-scores was performed via paired samples t-test. The effect of relapses on the HRQoL changes over time was explored via linear mixed-effects analysis. No longitudinal changes were observed in the overall PedsQL score, nor in the physical, school and psychological functioning. An increase in the social functioning subscale (p < 0.001) and a decrease in the emotional subscale (p = 0.006) were observed. The change in social functioning, but not the one in the emotional subscale, was affected by the occurrence of relapses (p = 0.044). In conclusion, stimulating the patients to accept their emotional responses to health-related limitations, while preserving their social and relational resources seems key to the preservation of an adequate QoL over time in juvenile-onset MS.
2022
Quality of Life Changes in Early-Onset Multiple Sclerosis: A 4-Year Follow-Up Study / Rosa, Laura; Petracca, Maria; Carotenuto, Antonio; Dolce, Pasquale; Piscopo, Kyrie; Dicé, Francesca; Lauro, Francesca; Spiezia, Antonio Luca; Moccia, Marcello; Lavorgna, Luigi; Iacovazzo, Carmine; Servillo, Giuseppe; Maldonato, Nelson Mauro; Chiodi, Alessandro; Brescia Morra, Vincenzo; Lanzillo, Roberta. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 11:17(2022), p. 5226. [10.3390/jcm11175226]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/905092
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