Psychoactive compounds, and benzodiazepines (BZPs) in particular, represent an important class of emerging pollutants due to their large (ab)use and high resistance to degradation. Nowadays it is known that sewage treatment does not completely eliminate these substances and, therefore, BZPs and their metabolites reach concern levels in most aquatic environments all over Europe, ranging from μg/L to ng/L. In this study, we investigated the effects of delorazepam on Mytilus galloprovincialis, a model organism in toxicity testing and a key species in coastal marine ecosystems. Given its psychoactive activity, the study primarily addressed discovering the effects on behavior, by conventional valve opening and closure tests. Possible cytotoxic activity was also investigated by analyzing valve abductor muscles, gills histology, and correlated oxygen consumption. Results demonstrate negative effects on mussel behavior, interference with metabolism, and alteration of gill morphology and protein content. In conclusion, delorazepam confirms its toxicity to aquatic environments, highlighting the possibility that BZDs can ultimately affect the structure of the food web and the functions of the coastal ecosystems.

Behavioral alterations and gills damage in Mytilus galloprovincialis exposed to an environmental concentration of delorazepam / Fogliano, Chiara; Carotenuto, Rosa; Panzuto, Raffaele; Spennato, Valentina; DE BONIS, Salvatore; Simoniello, Palma; Raggio, Anja; Avallone, Bice; Agnisola, Claudio; Motta, CHIARA MARIA. - In: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY. - ISSN 1382-6689. - 97:104030(2022), pp. 1-7. [10.1016/j.etap.2022.104030]

Behavioral alterations and gills damage in Mytilus galloprovincialis exposed to an environmental concentration of delorazepam

Chiara Fogliano
Primo
Methodology
;
Rosa Carotenuto
Secondo
;
Salvatore De Bonis;Palma Simoniello;Bice Avallone
Membro del Collaboration Group
;
Claudio Agnisola
Penultimo
Membro del Collaboration Group
;
Chiara Maria Motta
Ultimo
Membro del Collaboration Group
2022

Abstract

Psychoactive compounds, and benzodiazepines (BZPs) in particular, represent an important class of emerging pollutants due to their large (ab)use and high resistance to degradation. Nowadays it is known that sewage treatment does not completely eliminate these substances and, therefore, BZPs and their metabolites reach concern levels in most aquatic environments all over Europe, ranging from μg/L to ng/L. In this study, we investigated the effects of delorazepam on Mytilus galloprovincialis, a model organism in toxicity testing and a key species in coastal marine ecosystems. Given its psychoactive activity, the study primarily addressed discovering the effects on behavior, by conventional valve opening and closure tests. Possible cytotoxic activity was also investigated by analyzing valve abductor muscles, gills histology, and correlated oxygen consumption. Results demonstrate negative effects on mussel behavior, interference with metabolism, and alteration of gill morphology and protein content. In conclusion, delorazepam confirms its toxicity to aquatic environments, highlighting the possibility that BZDs can ultimately affect the structure of the food web and the functions of the coastal ecosystems.
2022
Behavioral alterations and gills damage in Mytilus galloprovincialis exposed to an environmental concentration of delorazepam / Fogliano, Chiara; Carotenuto, Rosa; Panzuto, Raffaele; Spennato, Valentina; DE BONIS, Salvatore; Simoniello, Palma; Raggio, Anja; Avallone, Bice; Agnisola, Claudio; Motta, CHIARA MARIA. - In: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY. - ISSN 1382-6689. - 97:104030(2022), pp. 1-7. [10.1016/j.etap.2022.104030]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/902860
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