A new study proposes that the cancerous behavior of B cells in a subtype of diffuse large B-cell lymphoma is caused by excessive activity of the linear ubiquitin chain assembly complex (LUBAC) complex, which underlies abnormal NF-κB signaling. Two rare germline single-nucleotide polymorphisms in the RNF31 gene have been identified as being responsible. The use of a small inhibiting peptide may downregulate the abnormal LUBAC activity and counteract neoplastic cell growth.
Germline polymorphisms in RNF31 regulate linear ubiquitination and oncogenic signaling / Grumati, Paolo; Dikic, Ivan. - In: CANCER DISCOVERY. - ISSN 2159-8290. - 4:4(2014), pp. 394-396. [10.1158/2159-8290.CD-14-0177]
Germline polymorphisms in RNF31 regulate linear ubiquitination and oncogenic signaling
Grumati, Paolo;
2014
Abstract
A new study proposes that the cancerous behavior of B cells in a subtype of diffuse large B-cell lymphoma is caused by excessive activity of the linear ubiquitin chain assembly complex (LUBAC) complex, which underlies abnormal NF-κB signaling. Two rare germline single-nucleotide polymorphisms in the RNF31 gene have been identified as being responsible. The use of a small inhibiting peptide may downregulate the abnormal LUBAC activity and counteract neoplastic cell growth.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.